Genome sequence conservation of Hendra virus isolates during spillover to horses, Australia.

Glenn A Marsh1 Shawn Todd Adam Foord Eric Hansson Kelly Davies Lynda Wright Chris Morrissy Kim Halpin Deborah Middleton Hume E Field Peter Daniels Lin-Fa Wang
Affiliations 1 institutions
  1. Australian Animal Health Laboratory, Geelong, Victoria, Australia. [email protected]

Abstract

Bat-to-horse transmission of Hendra virus has occurred at least 14 times. Although clinical signs in horses have differed, genome sequencing has demonstrated little variation among the isolates. Our sequencing of 5 isolates from recent Hendra virus outbreaks in horses found no correlation between sequences and time or geographic location of outbreaks.

Supporting text Virus Host Location
Chiroptera 371 Genome, Viral 317 Animals 1948 Australia 28 Disease Outbreaks 170 Hendra Virus 39 Henipavirus Infections 65 Horse Diseases 21 Horses 52 Phylogeny 805

Evidence records

2 total
Transmission Evidence
1 records · 1 evidence types
Evidence type
1 records
OVE876
Key finding

Hendra virus spilled over naturally from bats to horses in multiple events in Australia.

Virus
Host
Location
Not specified
Supporting text

Bat-to-horse transmission of Hendra virus has occurred at least 14 times.

Method
epidemiologic investigation | virus isolation
Study design
field outbreak investigation
Transmission direction
animal-to-animal
Genomic Evolution
1 records · 1 evidence types
Evidence type
1 records
OVE877
Key finding

Genome sequencing of five Hendra virus isolates from horse outbreaks showed high sequence conservation with no correlation between genetic variation and outbreak time or location.

Virus
Host
Location
Not specified
Supporting text

Our sequencing of 5 isolates from recent Hendra virus outbreaks in horses found no correlation between sequences and time or geographic location of outbreaks.

Genes or proteins
genome
Analysis methods
genome sequencing | comparative phylogenetic analysis