OmniVira

Unusual case of severe fever with thrombocytopenia syndrome showing clinical manifestations in a companion dog.

So-Jeong Nam1 Ye-In Oh2 Hyun-Jung Kim3 Doo-Sung Cheon4 Sung-Jun Noh5 Yeon-Jung Hong1
Affiliations 5 institutions
  1. Western Animal Medical Center, Seoul, South Korea.
  2. Chungnam National University, Daejeon, South Korea.
  3. Animal and Plant Quarantine Agency, Gimcheon, South Korea.
  4. Postbio Inc., Guri-si, South Korea.
  5. Naeum Animal Medical Center, Cheongju, South Korea.
PMID32279458 DOI10.1002/vms3.261 Year2020 Journal Veterinary medicine and science Vet Med Sci Languageeng Statusppublish

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) virus is an emerging zoonotic virus in East Asia. However, SFTS virus (SFTSV) has not been reported to cause clinical infection in companion dogs to date. We report the case of a 4-year-old companion dog that presented with fever, vomiting, leukocytopenia and thrombocytopenia at a veterinary hospital in the Republic of Korea. It was diagnosed with SFTS, which was confirmed using real-time reverse transcription PCR, sequencing and an indirect immunofluorescence assay, and recovered after supportive care. Further studies are required to investigate SFTSV infection in companion animals, living in close contact with humans, as well as animal-to-human transmission.

Supporting text Virus Host Location
dog 19 Huaiyangshan banyangvirus 1 Republic of Korea 27 severe fever with thrombocytopenia syndrome 2 tick 6 Animals 1948 Dog Diseases 65 Dogs 176 Fever 2 Leukopenia 1 Male 224 Phlebovirus 5 Republic of Korea 27 Severe Fever with Thrombocytopenia Syndrome 2 Thrombocytopenia 1 Treatment Outcome 2 Vomiting 1

Evidence records

2 total
Zoonotic Surveillance
1 records · 1 evidence types
Evidence type Viral Detection
1 records
OVE3726 Viral Detection
Key finding

SFTS virus (SFTSV) was molecularly and serologically detected in a companion dog in the Republic of Korea.

Virus
severe fever with thrombocytopenia syndrome virus
Host
dog Canis lupus familiaris Natural host
Location
South Korea
Supporting text

We report the case of a 4-year-old companion dog that presented with fever, vomiting, leukocytopenia and thrombocytopenia at a veterinary hospital in the Republic of Korea. It was diagnosed with SFTS, which was confirmed using real-time reverse transcription PCR, sequencing and an indirect immunofluorescence assay.

Method
real-time reverse transcription PCR | sequencing | indirect immunofluorescence assay
Sample type
clinical specimens
Geographic raw
Republic of Korea
Country inferred
KOR
Transmission Evidence
1 records · 1 evidence types
Evidence type Outbreak Investigation
1 records
OVE3727 Outbreak Investigation
Key finding

A clinical case investigation identified severe fever with thrombocytopenia syndrome virus infection in a 4-year-old companion dog in the Republic of Korea.

Virus
severe fever with thrombocytopenia syndrome virus
Host
dog Canis lupus familiaris Natural host
Location
South Korea
Supporting text

We report the case of a 4-year-old companion dog that presented with fever, vomiting, leukocytopenia and thrombocytopenia at a veterinary hospital in the Republic of Korea. It was diagnosed with SFTS, which was confirmed using real-time reverse transcription PCR, sequencing and an indirect immunofluorescence assay.

Method
real-time reverse transcription PCR | sequencing | indirect immunofluorescence assay | clinical case investigation
Transmission direction
same-species transmission
Geographic raw
Republic of Korea
Country inferred
KOR
Outbreak setting
veterinary hospital
Outbreak scale
single clinical case