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Literature detail

Possible Bat Origin of Severe Acute Respiratory Syndrome Coronavirus 2.

Susanna K P Lau Hayes K H Luk Antonio C P Wong Kenneth S M Li Longchao Zhu Zirong He Joshua Fung Tony T Y Chan Kitty S C Fung Patrick C Y Woo
PMID 32315281 2020 Emerg Infect Dis eng ppublish
PubMed DOI Browse context

Article

Publication summary

We showed that severe acute respiratory syndrome coronavirus 2 is probably a novel recombinant virus. Its genome is closest to that of severe acute respiratory syndrome-related coronaviruses from horseshoe bats, and its receptor-binding domain is closest to that of pangolin viruses. Its origin and direct ancestral viruses have not been identified.

bats coronavirus disease COVID-19 genomic analysis recombinant virus recombination respiratory infections SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 viruses zoonoses Animals Betacoronavirus Chiroptera Phylogeny Recombination, Genetic SARS-CoV-2

Structured evidence records

Evidence records

2 total
Genomic Evolution 1 records
Genomic Evolution Extraction confidence 0.90
Key finding

Genomic comparison indicates SARS-CoV-2 is a recombinant coronavirus most closely related to bat SARS-related viruses and shares its receptor-binding domain with pangolin viruses.

Virus
SARS-CoV-2
Location
Not specified
Supporting text

We showed that severe acute respiratory syndrome coronavirus 2 is probably a novel recombinant virus. Its genome is closest to that of severe acute respiratory syndrome-related coronaviruses from horseshoe bats, and its receptor-binding domain is closest to that of pangolin viruses.

Genes or proteins
receptor-binding domain
Analysis methods
genomic analysis; phylogenetic analysis; comparative genomics
Recombination Or Reassortment 1 records
Recombination Or Reassortment Extraction confidence 1.00
Key finding

SARS-CoV-2 is likely a recombinant virus combining genomic regions related to bat SARS-related coronaviruses and pangolin viruses.

Host
Not specified
Location
Not specified
Supporting text

We showed that severe acute respiratory syndrome coronavirus 2 is probably a novel recombinant virus. Its genome is closest to that of severe acute respiratory syndrome-related coronaviruses from horseshoe bats, and its receptor-binding domain is closest to that of pangolin viruses.

Event type
recombination
Genes or segments
receptor-binding domain