OmniVira

Literature detail

Virome characterization of field-collected rodents in suburban city.

Zhen-Yu Hu1,2,3 Fang Tang4 Mei-Qi Zhang2 Jing-Tao Zhang2 Yun-Fa Zhang2 Guang-Qian Si2,5 Bo-Kang Fu1,2 Gang Wang2 Shuang Li2 Lei Zhang2 Cong Peng2 Xiao-Fang Ma6 Yan-Tao Liu6 Hong Su1 Peng-Tao Bao7 Xiao-Ai Zhang8,9 Wei Liu10,11,12
Affiliations 12 institutions
  1. School of Public Health, Anhui Medical University, Hefei, China.
  2. State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Science, Beijing, China.
  3. The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  4. Institute of Medical Prevention and Control of Public Health Emergencies, Characteristic Medical Center of the Chinese People's Armed Police Force, Beijing, China.
  5. The Eighth Medical Center of Chinese PLA General Hospital, Beijing, China.
  6. Qingdao Municipal Center for Disease Control and Prevention, Qingdao, China.
  7. The Eighth Medical Center of Chinese PLA General Hospital, Beijing, China. [email protected].
  8. School of Public Health, Anhui Medical University, Hefei, China. [email protected].
  9. State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Science, Beijing, China. [email protected].
  10. School of Public Health, Anhui Medical University, Hefei, China. [email protected].
  11. State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Science, Beijing, China. [email protected].
  12. The First Affiliated Hospital of Anhui Medical University, Hefei, China. [email protected].
PMID 40500267 2025 NPJ Biofilms Microbiomes eng epublish
PubMed DOI Browse context

Article

Publication summary

Rodents serve as natural reservoirs and vectors for a multitude of zoonotic viruses. Analyzing the viral diversity in rodents is crucial for predicting the emergence of infectious diseases. Through high-throughput sequencing, we characterized the RNA virome of nine rodent species from the families Cricetidae and Muridae, collected from suburban Beijing (n = 432). The composition of the virome exhibited significant variation at the virus family level across the nine rodent species and three types of natural habitats. A total of 142 viral species were identified, including 133 associated with vertebrates and 9 associated with invertebrates, spanning 26 families. Notably, 75 of these viruses were novel while 67 were known viruses. Twenty-five viruses were classified as high-risk, including eight zoonotic viruses and 17 spillover-risk viruses. Additionally, nine known viruses were identified for the first time in China. Thirty-three viruses demonstrated potential for cross-species transmission. Understanding the virome characterization of field-collected rodent might provide valuable insights into the potential risk of zoonotic spillover to humans.

Rodentia Virome Viruses Animals Beijing China Disease Reservoirs High-Throughput Nucleotide Sequencing Humans Phylogeny Zoonoses

Structured evidence records

Evidence records

4 total
Cross Species Transmission 1 records
Cross Species Transmission Extraction confidence 0.80
Key finding

Virome analysis of nine rodent species revealed 33 viruses with potential to transmit between different rodent species.

Virus
Not specified
Location
China Beijing, China
Supporting text

Thirty-three viruses demonstrated potential for cross-species transmission.

Method
high-throughput sequencing
Study design
field surveillance
Transmission direction
animal-to-animal
Geographic raw
Beijing
Country inferred
China
Genomic Evolution 1 records
Genomic Evolution Extraction confidence 0.85
Key finding

High-throughput sequencing revealed extensive genomic diversity in the rodent virome from suburban Beijing, including numerous novel viruses.

Virus
Not specified
Host
Rodentia
Location
Not specified
Supporting text

Through high-throughput sequencing, we characterized the RNA virome of nine rodent species from the families Cricetidae and Muridae, collected from suburban Beijing (n = 432)... A total of 142 viral species were identified... Notably, 75 of these viruses were novel while 67 were known viruses.

Analysis methods
high-throughput sequencing; phylogenetic analysis
Reservoir Ecology 1 records
Reservoir Ecology Extraction confidence 0.70
Key finding

Rodents from suburban Beijing harbored diverse viruses with virome composition varying among species and habitat types, indicating ecological influences on viral reservoirs.

Virus
Not specified
Location
China suburban Beijing, China
Supporting text

Through high-throughput sequencing, we characterized the RNA virome of nine rodent species from the families Cricetidae and Muridae, collected from suburban Beijing (n = 432). The composition of the virome exhibited significant variation at the virus family level across the nine rodent species and three types of natural habitats.

Method
high-throughput sequencing; field sampling
Geographic raw
suburban Beijing
Country inferred
China
Zoonotic Surveillance 1 records
Zoonotic Surveillance Extraction confidence 0.98
Key finding

High-throughput sequencing of field-collected rodents in suburban Beijing revealed diverse RNA viruses, including zoonotic and spillover-risk species.

Virus
Not specified
Host
Rodentia
Location
China suburban Beijing, China
Supporting text

Through high-throughput sequencing, we characterized the RNA virome of nine rodent species from the families Cricetidae and Muridae, collected from suburban Beijing (n = 432).

Method
high-throughput sequencing
Geographic raw
suburban Beijing
Country inferred
China