Recent evidence findings
Synthesizing linked evidence and source literature...
Generating an evidence-grounded brief with GPT-5... AI-assisted synthesis grounded in linked OVE records and source literature. Verify details against the cited evidence.
4 source articles
5 hosts
1 countries
| Publication date | Category / type | Key finding | PMID |
|---|---|---|---|
| 2026-08-14 | Genomic Evolution Phylogenetic Evolution | Pakistani bat DENV-2 sequences cluster phylogenetically with bat-associated Costa Rica isolates as well as mosquito- and human-derived DENV-2 strains, indicating a potential cross-species viral link. | 42600670 |
| 2026-08-14 | Zoonotic Surveillance Viral Detection | Dengue virus serotype 2 (DENV-2) RNA was detected in bat fecal samples from multiple cities in Pakistan, with 14 amplified sequences confirmed by phylogenetic analysis. | 42600670 |
| 2026-08-14 | Functional Mechanism Molecular Adaptation | Pakistani bat-associated DENV-2 showed unique amino acid substitutions in the CprM region that may indicate host-specific adaptation or regional evolution. | 42600670 |
| 2026-08-10 | Functional Mechanism Molecular Adaptation | Deletion of 3'UTR SLI and/or SLIII in TMUV impairs replication in avian cells but not mammalian cells, and dual deletion reduces virulence in ducklings with limited impact in mice. | 42578371 |
| 2026-08-10 | Functional Mechanism Molecular Adaptation | TMUV 3'UTR SLI/SLIII promote replication in avian cells via interaction with the host factor CELF2. | 42578371 |
| 2026-08-10 | Functional Mechanism Molecular Adaptation | Duplication of SLII in the TMUV 3'UTR enhances replication in mammalian and avian cells but not mosquito cells, indicating host-specific proliferation effects. | 42578371 |
| 2026-08-10 | Functional Mechanism Molecular Adaptation | Replacing JEV SLI/SLIII with homologous elements from a duck-associated strain increases JEV proliferation in avian cells. | 42578371 |
| 2026-08-10 | Functional Mechanism Molecular Adaptation | TMUV mutants retaining only one 3'UTR stem-loop are replication-attenuated, with efficiency dependent on which SL is retained. | 42578371 |
| 2026-07-29 | Experimental Infection Pathogenicity Experiment | Chicken-derived TMUV isolate WH2025 (cluster 3.2) caused 100% mortality in experimentally infected mice, indicating highest pathogenicity among tested isolates. | 42523112 |
| 2026-07-29 | Experimental Infection Host Range Experiment | Five TMUV isolates from clusters 2.1.1, 2.1.2, 2.2, 3.1, and 3.2 were experimentally tested in mice to assess mammalian pathogenicity; the chicken-derived cluster 3.2 isolate WH2025 caused 100% mortality. | 42523112 |
| 2026-07-29 | Experimental Infection Host Range Experiment | In Culex quinquefasciatus, contemporary duck-derived TMUV isolates from clusters 2 and 3.2 replicated and infected more efficiently than the ancestral mosquito-derived isolate MM 1775 (cluster 3.1). | 42523112 |
| 2026-07-17 | Functional Mechanism Molecular Adaptation | Host splicing factor domains U2AF1 RS and Zn1, and nearly all domains of U2AF2 except its RS domain, are required for proviral function during orthoflavivirus infection. | 42464737 |
| 2026-07-17 | Experimental Infection Host Range Experiment | Trans-complementation with the Aedes aegypti homolog u2af38 in U2AF1-knockout cells restores ZIKV replication, indicating cross-species functional support for infection. | 42464737 |
| 2026-07-17 | Functional Mechanism Molecular Adaptation | Host factors U2AF1 and U2AF2 bind viral RNA, with U2AF1 binding dependent on U2AF2, supporting a mechanistic role in viral protein synthesis/replication. | 42464737 |
| 2026-07-17 | Experimental Infection Host Range Experiment | Expressing Aedes aegypti u2af50 in U2AF2-knockdown cells did not restore ZIKV replication. | 42464737 |
| 2026-07-17 | Experimental Infection Host Range Experiment | U2AF2 and U2AF1 are critical host factors for efficient infection by Dengue virus and Zika virus at the viral protein synthesis stage in infected cells. | 42464737 |
| 2026-07-17 | Experimental Infection Host Range Experiment | Disrupting the U2AF1–U2AF2 interaction potently suppresses ZIKV infection in cells. | 42464737 |
No publication-dated literature was found for this virus in this window.
Generating an evidence-grounded brief with GPT-5... AI-assisted synthesis grounded in linked OVE records and source literature. Verify details against the cited evidence.
0 source articles
0 hosts
0 countries
| Publication date | Category / type | Key finding | PMID |
|---|---|---|---|
| No publication-dated evidence in this window. | |||
No publication-dated literature was found for this virus in this window.
Generating an evidence-grounded brief with GPT-5... AI-assisted synthesis grounded in linked OVE records and source literature. Verify details against the cited evidence.
0 source articles
0 hosts
0 countries
| Publication date | Category / type | Key finding | PMID |
|---|---|---|---|
| No publication-dated evidence in this window. | |||