Virus entity

Orthohantavirus

ScopeICTV Genus

Recent evidence findings

Evidence-grounded Research Brief · Past 3 months 15

Synthesizing linked evidence and source literature...

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4 source articles 6 hosts 2 countries
Publication date Category / type Key finding PMID
2026-07 Zoonotic Surveillance Viral Detection Tula orthohantavirus (TULV) was detected in 127 infected voles across 58 trapping sites, including 27 reassortant TULV detections within a 12.5 km hybrid zone. 42520069
2026-07 Genomic Evolution Phylogenetic Evolution Phylogenomic analyses show three independent reassortment events in Tula orthohantavirus with dominance of a lineage carrying a reassorted M segment across a host hybrid zone. 42520069
2026-07 Genomic Evolution Phylogenetic Evolution A viral hybrid zone of TULV reassortants spans a ~12.5 km region concordant with the host hybrid zone, with 27 reassortant genomes detected among 127 infected voles from 58 sites. 42520069
2026-07 Functional Mechanism Molecular Adaptation TULV clades and dominant reassortants exhibit clade-specific N-terminal glycoprotein variation, including five residues (two under positive selection) that form uniquely structured regions, implicating adaptive glycoprotein changes. 42520069
2026-07 Genomic Evolution Phylogenetic Evolution Clade-specific variation in the TULV glycoprotein N-terminal region involves five residues, with two sites showing evidence of positive selection. 42520069
2026-07 Genomic Evolution Phylogenetic Evolution In silico 3D modeling shows the glycoprotein N-terminal region is uniquely structured for each TULV clade and dominant reassortants and is the only structurally variable glycoprotein region. 42520069
2026-06-30 Zoonotic Surveillance Virus Isolation Infectious Hokkaido virus (HOKV) was successfully recovered from oral swabs, urine, and feces of wild Myodes rufocanus bedfordiae captured in Tobetsu, Hokkaido, Japan. 42377061
2026-06-30 Zoonotic Surveillance Viral Detection Hokkaido virus (HOKV) RNA and antigens were detected in lungs, kidneys, and spleen of wild gray red-backed voles (Myodes rufocanus bedfordiae) captured in Tobetsu, Hokkaido, Japan. 42377061
2026-06-30 Zoonotic Surveillance Serological Evidence Some Myodes rufocanus bedfordiae voles captured in Tobetsu, Hokkaido, Japan were negative for anti-HOKV IgG but had low neutralizing antibody titers and IgG avidity, consistent with acute Hokkaido virus (HOKV) infection. 42377061
2026-06-30 Zoonotic Surveillance Serological Evidence Wild Myodes rufocanus bedfordiae voles captured in Tobetsu, Hokkaido, Japan showed high antibody titers and high IgG avidities to Hokkaido virus (HOKV), indicating persistent infection. 42377061
2026-05 Zoonotic Surveillance Viral Detection A Puumala orthohantavirus (Guyuan strain) was detected in Myodes rufocanus rodents collected in Hebei Province, China. 42113832
2026-05 Zoonotic Surveillance Reservoir Ecology A distinct genotype of Puumala orthohantavirus was found to be circulating in rodents in Hebei Province, indicating ecological maintenance of the virus in local rodent populations. 42113832
2026-05 Genomic Evolution Phylogenetic Evolution Phylogenetic analysis showed that the Puumala orthohantavirus Guyuan strain identified in Myodes rufocanus from Hebei Province represents a distinct genotype clustering within the PUUV lineage but with only about 80–84% nucleotide identity to known reference strains. 42113832
2026-05 Genomic Evolution Phylogenetic Evolution Genomic and phylogenetic analyses showed that the newly discovered bandavirus in black vultures is most closely related to Hunter Island virus. 41685543
2026-05 Zoonotic Surveillance Viral Detection Puumala orthohantavirus antigen and viral particles were detected in multiple organs of Myodes rufocanus by immunofluorescence and electron microscopy, showing multiorgan tropism. 42113832
Evidence-grounded Research Brief · Past month 6

Synthesizing linked evidence and source literature...

Generating an evidence-grounded brief with GPT-5...
1 source articles 2 hosts 0 countries
Publication date Category / type Key finding PMID
2026-07 Zoonotic Surveillance Viral Detection Tula orthohantavirus (TULV) was detected in 127 infected voles across 58 trapping sites, including 27 reassortant TULV detections within a 12.5 km hybrid zone. 42520069
2026-07 Genomic Evolution Phylogenetic Evolution Phylogenomic analyses show three independent reassortment events in Tula orthohantavirus with dominance of a lineage carrying a reassorted M segment across a host hybrid zone. 42520069
2026-07 Genomic Evolution Phylogenetic Evolution A viral hybrid zone of TULV reassortants spans a ~12.5 km region concordant with the host hybrid zone, with 27 reassortant genomes detected among 127 infected voles from 58 sites. 42520069
2026-07 Functional Mechanism Molecular Adaptation TULV clades and dominant reassortants exhibit clade-specific N-terminal glycoprotein variation, including five residues (two under positive selection) that form uniquely structured regions, implicating adaptive glycoprotein changes. 42520069
2026-07 Genomic Evolution Phylogenetic Evolution Clade-specific variation in the TULV glycoprotein N-terminal region involves five residues, with two sites showing evidence of positive selection. 42520069
2026-07 Genomic Evolution Phylogenetic Evolution In silico 3D modeling shows the glycoprotein N-terminal region is uniquely structured for each TULV clade and dominant reassortants and is the only structurally variable glycoprotein region. 42520069
Evidence-grounded Research Brief · Past week 0

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Publication date Category / type Key finding PMID
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Evidence-related Animal

Evidence-related animal composition

26 animal taxa

Geographic evidence

Evidence distribution by country

12 countries

Temporal evidence

Evidence dynamics by year

42 year-type groups

Publication output

Source articles by month

217 months