Virus entity

Influenza A virus H3N2

Levelsubtype IAV H3N2

Recent evidence findings

Research Brief · Past 3 months 13

Generating research brief from recent literature...

Summarizing recent literature with GPT-5...
3 literature 6 hosts 1 countries
Publication date Type Key finding PMID
2026-05-08 Molecular Adaptation Hypoxia enhances N110 glycosylation of H3N2 hemagglutinin via the host B4GAT1-B4GALT1 complex, increasing receptor-binding ability, replication, and immune evasion. 42198750
2026-05-08 Host Range Experiment Ferret models showed that N110-glycosylated H3N2 viruses had increased pathogenicity and antibody evasion. 42198750
2026-04-21 Spillover Event Human seasonal H3N2 influenza A viruses have been repeatedly transmitted from humans to swine, confirming a human-to-animal spillover event and identifying factors affecting susceptibility. 41891722
2026-04-21 Host Range Experiment Piglets could be experimentally infected with a human-like H3N2 influenza A virus, resulting in replication and transmission to contact pigs, demonstrating swine susceptibility to a human seasonal influenza strain. 41891722
2026-04-21 Cross Species Transmission Human-origin H3N2 influenza A virus transmitted between piglets during direct-contact experiments, showing swine-to-swine transmission following host adaptation from humans. 41891722
2026-04 Receptor Usage A/Swine/Jiangsu/YZ07/2024 H3N2 swine influenza virus shows enhanced human-type α-2,6-linked sialic acid receptor binding mediated by HA residues 190D, 225D, and 228S. 41671764
2026-04 Zoonotic Surveillance A reassortant H3N2 swine influenza virus was identified from clinically affected pigs during epidemiological surveillance in Northern Jiangsu, China. 41671764
2026-04 Host Range Experiment In vivo mouse infection showed replication of the H3N2 virus in nasal turbinates and lungs, causing pulmonary lesions. 41671764
2026-04 Host Range Experiment The H3N2 swine influenza virus showed efficient replication in mammalian cells, consistent with enhanced mammalian tropism. 41671764
2026-04 Host Range Experiment The H3N2 swine influenza virus replicated poorly in chicken embryos and chicken cells but efficiently in mammalian cells, showing host-specific replication capacity. 41671764
2026-04 Molecular Adaptation The reassortant H3N2 swine influenza virus displays higher polymerase activity and enhanced replication efficiency in mammalian cells compared to avian cells. 41671764
2026-04 Molecular Adaptation Residues 190D, 225D, and 228S in the HA protein of the H3N2 swine influenza virus increase binding to human-type α-2,6-linked sialic acid receptors, indicating adaptation toward human hosts. 41671764
2026-04 Genomic Evolution The H3N2 swine influenza virus A/Swine/Jiangsu/YZ07/2024 shows genomic evolution through reassortment with internal genes from 2009 pandemic H1N1 and surface genes of human-like origin, indicating cross-lineage mixing and potential host adaptation. 41671764
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Evidence-related Animal

Evidence-related animal composition

11 animal taxa

Geographic evidence

Evidence distribution by country

10 countries

Temporal evidence

Evidence dynamics by year

87 year-type groups

Publication output

Literature publications by month

320 months