Virus entity

Severe acute respiratory syndrome coronavirus 2

Levelvirus SARS-CoV-2

Recent evidence findings

Research Brief · Past 3 months 22

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8 literature 12 hosts 4 countries
Publication date Type Key finding PMID
2026-06-02 Host Range Experiment Antibody-based chimeric receptors enabled efficient infection and replication of diverse sarbecoviruses from animal and clinical sources, demonstrating that receptor specificity can be reprogrammed beyond human ACE2 dependence. 42230999
2026-06-02 Molecular Adaptation The E7 antibody-derived chimeric receptor recognized conserved epitopes across sarbecoviruses from all clades, providing molecular evidence for cross-sarbecovirus binding breadth. 42230999
2026-06 Zoonotic Surveillance Roe deer in Sweden tested negative for SARS-CoV-2 RNA during surveillance performed from 2016 to 2022. 41783616
2026-05-20 Serological Evidence Wild mammals including foxes, badgers, hedgehogs, roe deer, wolf, and rat showed serological evidence of exposure to SARS-CoV-2, confirmed by anti-RBD ELISA. 42163369
2026-05-20 Zoonotic Surveillance Wild mammals in Northern Italy were monitored for SARS-CoV-2 and other coronaviruses, providing evidence of coronavirus circulation and serological exposure to SARS-CoV-2. 42163369
2026-05-13 Molecular Adaptation A single amino acid difference in Orf9b between SARS-CoV-2 and RaTG13 acts as a molecular switch, redirecting binding between Tom70 and MTARC2, thereby modulating immune evasion and viral adaptation to human versus bat hosts. 42134328
2026-05-13 Molecular Adaptation A nonsynonymous mutation in the SARS-CoV-2 nucleocapsid protein enables replication in bat cells expressing human ACE2 and TMPRSS2, highlighting a molecular adaptation influencing cross-species infectivity. 42134328
2026-04-09 Receptor Usage Elk ACE2 weakly binds ancestral and Delta SARS-CoV-2 spike RBDs but strongly binds Alpha, Beta, Gamma, and Omicron RBDs, with structural assays confirming stable complex formation for the Alpha variant. 41957014
2026-04-09 Molecular Adaptation Elk ACE2 has a K31N substitution that weakens binding to ancestral and Delta SARS-CoV-2 spike RBDs, but viral N501Y mutation in Alpha, Beta, Gamma, and Omicron variants enhances ACE2–spike compatibility. 41957014
2026-04-09 Zoonotic Surveillance White-tailed deer are recognized as established reservoirs for SARS-CoV-2 in North America. 41957014
2026-04-09 Zoonotic Surveillance Field surveillance in the United States found only limited SARS-CoV-2 infection among elk, while widespread infections were observed in white-tailed deer. 41957014
2026-04-09 Host Range Experiment Elk ACE2 supports SARS-CoV-2 viral entry and replication in vitro, indicating species-specific susceptibility distinct from white-tailed deer. 41957014
2026-04-03 Serological Evidence Serum samples from rodents in rural Yucatan Peninsula, Mexico, showed 23.1% seropositivity for SARS-CoV-2 antibodies by indirect ELISA. 42043224
2026-04-03 Zoonotic Surveillance Serological surveillance of rodents in rural Yucatan Peninsula, Mexico, detected antibodies indicating SARS-CoV-2 exposure. 42043224
2026-04-03 Spillover Event Rodents from rural Mexico showed serological evidence of SARS-CoV-2 exposure, indicating possible sporadic human-to-rodent spillback events. 42043224
2026-04 Receptor Usage Red fox ACE2 acts as a functional receptor for SARS-CoV-2 and PCoV-GD, supporting pseudovirus entry and showing differential binding affinities in SPR assays. 41960421
2026-04 Molecular Adaptation Residue substitutions R417/H498 in PCoV-GD RBD and mutations such as Y453F in SARS-CoV-2 RBD modulate binding affinity to fox ACE2, indicating molecular adaptation of viral spike-RBDs for cross-species receptor recognition. 41960421
2026-04 Spillover Event Detection of SARS-CoV-2 RNA in red foxes shows that foxes were naturally infected, supporting a human-to-animal spillback event. 41960421
2026-03-25 Spillover Event SARS-CoV-2 spread from infected human caretakers to animals in US zoos, representing confirmed human-to-animal spillback events. 41880766
2026-03-25 Zoonotic Surveillance Animal surveillance data from US zoos confirmed SARS-CoV-2 infections in captive wildlife as part of national monitoring between 2020 and 2023. 41880766
2026-03-25 Genomic Evolution Comparative genomic and phylogenetic analyses indicated that SARS-CoV-2 infections in zoo animals originated from human variants, with no sustained viral evolution detected in these animal populations. 41880766
2026-03-25 Outbreak Investigation Confirmed human-to-animal SARS-CoV-2 outbreaks occurred among zoo animals in the United States between 2020 and 2023, with caretakers identified as the main exposure source. 41880766
Research Brief · Past month 5

Generating research brief from recent literature...

Summarizing recent literature with GPT-5...
3 literature 6 hosts 2 countries
Publication date Type Key finding PMID
2026-06-02 Host Range Experiment Antibody-based chimeric receptors enabled efficient infection and replication of diverse sarbecoviruses from animal and clinical sources, demonstrating that receptor specificity can be reprogrammed beyond human ACE2 dependence. 42230999
2026-06-02 Molecular Adaptation The E7 antibody-derived chimeric receptor recognized conserved epitopes across sarbecoviruses from all clades, providing molecular evidence for cross-sarbecovirus binding breadth. 42230999
2026-06 Zoonotic Surveillance Roe deer in Sweden tested negative for SARS-CoV-2 RNA during surveillance performed from 2016 to 2022. 41783616
2026-05-20 Serological Evidence Wild mammals including foxes, badgers, hedgehogs, roe deer, wolf, and rat showed serological evidence of exposure to SARS-CoV-2, confirmed by anti-RBD ELISA. 42163369
2026-05-20 Zoonotic Surveillance Wild mammals in Northern Italy were monitored for SARS-CoV-2 and other coronaviruses, providing evidence of coronavirus circulation and serological exposure to SARS-CoV-2. 42163369
Research Brief · Past week 0

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0 literature 0 hosts 0 countries
Publication date Type Key finding PMID
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Evidence-related Animal

Evidence-related animal composition

163 animal taxa

Geographic evidence

Evidence distribution by country

45 countries

Temporal evidence

Evidence dynamics by year

75 year-type groups

Publication output

Literature publications by month

77 months