Recent evidence findings
Synthesizing linked evidence and source literature...
Generating an evidence-grounded brief with GPT-5... AI-assisted synthesis grounded in linked OVE records and source literature. Verify details against the cited evidence.
3 source articles
4 hosts
0 countries
| Publication date | Category / type | Key finding | PMID |
|---|---|---|---|
| 2026-10-05 | Functional Mechanism Molecular Adaptation | nsp12 mutations I171V, A185S, R249K, and N611S increased replication in a SARS-CoV-2 replicon in human-cell context. | 42831623 |
| 2026-10-05 | Experimental Infection Host Range Experiment | Specific bat SARS-related coronavirus nsp12 mutations enhanced viral replication in both bat and human cells in controlled assays. | 42831623 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | Eight bat-derived nsp12 mutations increased polymerase activity at 37°C, with several also advantageous at 33°C or 40°C. | 42831623 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | Adaptive nsp12 mutations map to RNA capping and RdRp catalytic core regions without altering remdesivir sensitivity. | 42831623 |
| 2026-08-21 | Experimental Infection Host Range Experiment | RhGB01 and BM48-31 spikes utilized only Rhinolophus blasii ACE2 in entry assays. | 42627230 |
| 2026-07-21 | Functional Mechanism Molecular Adaptation | Several Guangdong pangolin coronaviruses carry a lysine substitution at spike residue 519 that confers marked immune evasion by modulating spike conformational state. | 42267927 |
Synthesizing linked evidence and source literature...
Generating an evidence-grounded brief with GPT-5... AI-assisted synthesis grounded in linked OVE records and source literature. Verify details against the cited evidence.
1 source articles
3 hosts
0 countries
| Publication date | Category / type | Key finding | PMID |
|---|---|---|---|
| 2026-10-05 | Functional Mechanism Molecular Adaptation | nsp12 mutations I171V, A185S, R249K, and N611S increased replication in a SARS-CoV-2 replicon in human-cell context. | 42831623 |
| 2026-10-05 | Experimental Infection Host Range Experiment | Specific bat SARS-related coronavirus nsp12 mutations enhanced viral replication in both bat and human cells in controlled assays. | 42831623 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | Eight bat-derived nsp12 mutations increased polymerase activity at 37°C, with several also advantageous at 33°C or 40°C. | 42831623 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | Adaptive nsp12 mutations map to RNA capping and RdRp catalytic core regions without altering remdesivir sensitivity. | 42831623 |
Synthesizing linked evidence and source literature...
Generating an evidence-grounded brief with GPT-5... AI-assisted synthesis grounded in linked OVE records and source literature. Verify details against the cited evidence.
1 source articles
3 hosts
0 countries
| Publication date | Category / type | Key finding | PMID |
|---|---|---|---|
| 2026-10-05 | Functional Mechanism Molecular Adaptation | nsp12 mutations I171V, A185S, R249K, and N611S increased replication in a SARS-CoV-2 replicon in human-cell context. | 42831623 |
| 2026-10-05 | Experimental Infection Host Range Experiment | Specific bat SARS-related coronavirus nsp12 mutations enhanced viral replication in both bat and human cells in controlled assays. | 42831623 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | Eight bat-derived nsp12 mutations increased polymerase activity at 37°C, with several also advantageous at 33°C or 40°C. | 42831623 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | Adaptive nsp12 mutations map to RNA capping and RdRp catalytic core regions without altering remdesivir sensitivity. | 42831623 |