Seoul virus

Research Brief · Past 3 months 4

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Publication date	Type	Key finding	PMID
2026-04-25	Zoonotic Surveillance	Meta-transcriptomic surveillance of 63 Rattus norvegicus and Rattus tanezumi individuals revealed over 600 RNA viruses, including zoonotic viruses; Seoul orthohantavirus was more prevalent in Rattus norvegicus.	42033733
2026-04-25	Cross Species Transmission	Seoul orthohantavirus shows differential prevalence between Rattus norvegicus and Rattus tanezumi, indicating cross-species transmission influenced by host genetic differences.	42033733
2026-04-25	Molecular Adaptation	Differences in host genes Itgb3 and Tlr7 between Rattus norvegicus and Rattus tanezumi are linked to differential susceptibility to Seoul orthohantavirus, indicating host-factor mediated molecular adaptation at the receptor level.	42033733
2026-04-25	Genomic Evolution	Meta-transcriptomic and population genomic analyses showed that Seoul orthohantavirus was more prevalent in Rattus norvegicus than Rattus tanezumi, and host genes Itgb3 and Tlr7 exhibited greater heterozygosity in R. norvegicus, suggesting genomic determinants of viral susceptibility.	42033733

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