OmniVira

Sparse serological evidence of H5N1 avian influenza virus infections in domestic cats, northeastern China.

Lingshuang Sun1,2 Pei Zhou1,3 Shuyi He4 Yongfeng Luo1,3 Kun Jia1,3 Cheng Fu1,3 Yao Sun1,3 Huamei He1,3 Liqing Tu1,3 Zhangyong Ning1,3 Ziguo Yuan1,3 Heng Wang1,3 Shoujun Li1,3 Liguo Yuan1,5
Affiliations 5 institutions
  1. College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong Province 510642, People's Republic of China
  2. Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases, Guangzhou, Guangdong Province 510642, People's Republic of China. Electronic address: [email protected].
  3. Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases, Guangzhou, Guangdong Province 510642, People's Republic of China.
  4. College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong Province 510642, People's Republic of China.
  5. Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases, Guangzhou, Guangdong Province 510642, People's Republic of China. Electronic address: [email protected].
PMID25752867 DOI10.1016/j.micpath.2015.03.003 Year2015 Journal Microbial pathogenesis Microb Pathog Languageeng Statusppublish

Abstract

Today the cross-species transmission of avian influenza viruses (AIV) are a great concern. A number of AIV strains are now enzootic among poultry, with H9N2 and highly pathogenic H5N1 AIV strains prevalent in China. H5N1 strains have been recognized to infect zoo and domestic feline species. In this serological study we sought to examine evidence that H5N1 strains have infected domestic cats in northeastern China. In 2013, we conducted a cross-sectional serological study of 916 healthy cats in Heilongjian, Jilin, and Liaonin Provinces. Sera were screened with a hemagglutinin inhibition (HI) assay and seropositive specimens (HI ≥ 1:20) were further evaluated with a microneutralization (MN) assay against a clade 2.3.2 H5N1 AIV, a H9N2 AIV, A (H1N1)pdm09, and a canine H3N2 virus. While ∼2% of cats had elevated HI assays against H5N1, no elevations were confirmed (MN ≥ 1:80). These data serve as baseline for future surveillance for AIV infections among domestic cats. Conducting such surveillance seems important for geographical areas recognized as endemic for AIVs. This is especially true for countries such as China where domestic cats and poultry are often in close contact.

Supporting text Virus Host Location
Cats 133 H5N1 82 Infection 12 Animals 1948 Antibodies, Neutralizing 80 Antibodies, Viral 212 Cat Diseases 67 Cats 120 China 229 Cross-Sectional Studies 35 Hemagglutination Inhibition Tests 15 Influenza A Virus, H3N2 Subtype 48 Influenza A Virus, H5N1 Subtype 300 Influenza A Virus, H9N2 Subtype 71 Neutralization Tests 31 Orthomyxoviridae Infections 228 Seroepidemiologic Studies 113

Evidence records

1 total
Zoonotic Surveillance
1 records · 1 evidence types
Evidence type Serological Evidence
1 records
OVE1968 Serological Evidence
Key finding

Approximately 2% of healthy domestic cats in northeastern China had elevated HI assay results against H5N1 AIV, but none were confirmed by microneutralization.

Virus
Influenza A virus H5N1
Host
domestic cat Felis catus Natural host
Location
Not specified
Supporting text

In 2013, we conducted a cross-sectional serological study of 916 healthy cats in Heilongjian, Jilin, and Liaonin Provinces. Sera were screened with a hemagglutinin inhibition (HI) assay and seropositive specimens (HI ≥ 1:20) were further evaluated with a microneutralization (MN) assay against a clade 2.3.2 H5N1 AIV... While ∼2% of cats had elevated HI assays against H5N1, no elevations were confirmed (MN ≥ 1:80).

Method
hemagglutinin inhibition (HI) assay | microneutralization (MN) assay
Sample type
Sera