OmniVira

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China.

Aiping Wu1,2 Yousong Peng3 Baoying Huang4 Xiao Ding1,2 Xianyue Wang1,2 Peihua Niu4 Jing Meng1,2 Zhaozhong Zhu3 Zheng Zhang3 Jiangyuan Wang1,2 Jie Sheng1,2 Lijun Quan5 Zanxian Xia6,7 Wenjie Tan8 Genhong Cheng9 Taijiao Jiang1,10
Affiliations 10 institutions
  1. Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China
  2. Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China.
  3. College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha 410082, China.
  4. Key Laboratory of Medical Virology, National Health and Family Planning Commission, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China.
  5. School of Computer Science and Technology, Soochow University, Suzhou, China.
  6. Department of Cell Biology, School of Life Science, Central South University, Changsha 410013, China
  7. Hunan Key Laboratory of Animal Models for Human Diseases, Hunan Key Laboratory of Medical Genetics & Center for Medical Genetics, School of Life Science, Central South University, Changsha 410013, China.
  8. Key Laboratory of Medical Virology, National Health and Family Planning Commission, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China. Electronic address: [email protected].
  9. Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, USA. Electronic address: [email protected].
  10. Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China. Electronic address: [email protected].
PMID32035028 DOI10.1016/j.chom.2020.02.001 Year2020 Journal Cell host & microbe Cell Host Microbe Languageeng Statusppublish

Abstract

An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses. A systematic comparison identified 380 amino acid substitutions between these coronaviruses, which may have caused functional and pathogenic divergence of 2019-nCoV.

Genome, Viral 317 Phylogeny 805 Amino Acid Substitution 81 Betacoronavirus 78 China 229 Coronavirus Infections 171 COVID-19 425 Middle East Respiratory Syndrome Coronavirus 68 Pandemics 108 Pneumonia, Viral 42 SARS-CoV-2 453 Severe acute respiratory syndrome-related coronavirus 78

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