OmniVira

Literature detail

Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV.

Rui Li1 Songlin Qiao1 Gaiping Zhang2,3
Affiliations 3 institutions
  1. Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China.
  2. Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China
  3. College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 45002, China. Electronic address: [email protected].
PMID 32092392 2020 J Infect eng ppublish
PubMed DOI Browse context

Article

Publication summary

No abstract text is available for this record.

Betacoronavirus Amino Acid Sequence Angiotensin-Converting Enzyme 2 Animals Coronavirus Infections COVID-19 Humans Models, Molecular Pandemics Peptidyl-Dipeptidase A Pneumonia, Viral Protein Conformation Receptors, Coronavirus Receptors, Virus SARS-CoV-2 Sequence Alignment Species Specificity ACE2 protein, human

Structured evidence records

Evidence records

3 total
Cross Species Transmission 1 records
Cross Species Transmission Extraction confidence 0.70
Key finding

Analysis of ACE2 receptors from various animal species suggests SARS-CoV-2 can recognize ACE2 from multiple species, supporting potential animal-to-animal cross-species transmission.

Virus
SARS-CoV-2
Host
Not specified
Location
Not specified
Supporting text

Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV.

Method
sequence alignment
Study design
molecular modeling
Transmission direction
animal-to-animal
Molecular Adaptation 1 records
Molecular Adaptation Extraction confidence 0.80
Key finding

SARS-CoV-2 was evaluated for its ability to use ACE2 receptors from different species, suggesting molecular adaptation related to cross-species receptor binding.

Virus
SARS-CoV-2
Host
Not specified
Location
Not specified
Supporting text

Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV.

Genes or proteins
ACE2
Receptors
ACE2
Mechanism types
receptor_binding
Receptor Usage 1 records
Receptor Usage Extraction confidence 0.95
Key finding

ACE2 receptor sequences from multiple species were analyzed to assess cross-species receptor usage of 2019-nCoV (SARS-CoV-2).

Virus
SARS-CoV-2
Host
Not specified
Location
Not specified
Supporting text

Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV.

Method
sequence analysis
Receptors
ACE2