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Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection.

Junwen Luan1 Yue Lu2,3 Xiaolu Jin2,3 Leiliang Zhang4
Affiliations 4 institutions
  1. Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong, China.
  2. Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong, China
  3. School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, 250200, Shandong, China.
  4. Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong, China. Electronic address: [email protected].
PMID32201080 DOI10.1016/j.bbrc.2020.03.047 Year2020 Journal Biochemical and biophysical research communications Biochem Biophys Res Commun Languageeng Statusppublish

Abstract

SARS-CoV-2 causes the recent global COVID-19 public health emergency. ACE2 is the receptor for both SARS-CoV-2 and SARS-CoV. To predict the potential host range of SARS-CoV-2, we analyzed the key residues of ACE2 for recognizing S protein. We found that most of the selected mammals including pets (dog and cat), pangolin and Circetidae mammals remained the most of key residues for association with S protein from SARS-CoV and SARS-CoV-2. The interaction interface between cat/dog/pangolin/Chinese hamster ACE2 and SARS-CoV/SARS-CoV-2 S protein was simulated through homology modeling. We identified that N82 in ACE2 showed a closer contact with SARS-CoV-2 S protein than M82 in human ACE2. Our finding will provide important insights into the host range of SARS-CoV-2 and a new strategy to design an optimized ACE2 for SARS-CoV-2 infection.

ACE2 54 Host range 30 SARS-CoV-2 550 Spike protein 32 Structure 6 Viral Tropism 45 Amino Acid Sequence 128 Angiotensin-Converting Enzyme 2 177 Animals 1949 Betacoronavirus 78 Coronavirus Infections 171 COVID-19 425 Humans 1441 Mammals 92 Models, Molecular 99 Pandemics 108 Peptidyl-Dipeptidase A 57 Pneumonia, Viral 42 SARS-CoV-2 453 Sequence Alignment 51 Spike Glycoprotein, Coronavirus 274 ACE2 protein, human 87 spike protein, SARS-CoV-2 157

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