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Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection.

Junwen Luan1 Yue Lu2,3 Xiaolu Jin2,3 Leiliang Zhang4
Affiliations 4 institutions
  1. Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong, China.
  2. Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong, China
  3. School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, 250200, Shandong, China.
  4. Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong, China. Electronic address: [email protected].
PMID32201080 DOI10.1016/j.bbrc.2020.03.047 Year2020 Journal Biochemical and biophysical research communications Biochem Biophys Res Commun Languageeng Publication statusActive
Active Last checked 2026-10-06 03:30:27 Source: NCBI PubMed

Abstract

SARS-CoV-2 causes the recent global COVID-19 public health emergency. ACE2 is the receptor for both SARS-CoV-2 and SARS-CoV. To predict the potential host range of SARS-CoV-2, we analyzed the key residues of ACE2 for recognizing S protein. We found that most of the selected mammals including pets (dog and cat), pangolin and Circetidae mammals remained the most of key residues for association with S protein from SARS-CoV and SARS-CoV-2. The interaction interface between cat/dog/pangolin/Chinese hamster ACE2 and SARS-CoV/SARS-CoV-2 S protein was simulated through homology modeling. We identified that N82 in ACE2 showed a closer contact with SARS-CoV-2 S protein than M82 in human ACE2. Our finding will provide important insights into the host range of SARS-CoV-2 and a new strategy to design an optimized ACE2 for SARS-CoV-2 infection.

ACE2 55 Host range 31 SARS-CoV-2 556 Spike protein 32 Structure 6 Viral Tropism 46 Amino Acid Sequence 128 Angiotensin-Converting Enzyme 2 178 Animals 1981 Betacoronavirus 79 Coronavirus Infections 172 COVID-19 427 Humans 1455 Mammals 92 Models, Molecular 99 Pandemics 109 Peptidyl-Dipeptidase A 58 Pneumonia, Viral 42 SARS-CoV-2 456 Sequence Alignment 51 Spike Glycoprotein, Coronavirus 276 ACE2 protein, human 87 spike protein, SARS-CoV-2 158

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