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Literature detail

Absence of SARS-CoV-2 infection in cats and dogs in close contact with a cluster of COVID-19 patients in a veterinary campus.

Sarah Temmam1,2 Alix Barbarino3 Djérène Maso3 Sylvie Behillil4 Vincent Enouf4 Christèle Huon1 Ambre Jaraud3,5,6 Lucie Chevallier3,5,6 Marija Backovic7 Philippe Pérot1,2 Patrick Verwaerde3,5 Laurent Tiret3,5,6 Sylvie van der Werf4 Marc Eloit1,2,3,1
Affiliations 7 institutions
  1. Institut Pasteur, Pathogen Discovery Laboratory, Paris, France.
  2. Institut Pasteur, The OIE Collaborating Centre for Detection and Identification in Humans of Emerging Animal Pathogens, Paris, France.
  3. École nationale vétérinaire d'Alfort, Maisons-Alfort, France.
  4. Institut Pasteur, National Reference Center for Respiratory Viruses, Molecular Genetics of RNA Viruses, CNRS-UMR 3569, Univ Paris, Paris, France.
  5. Univ Paris Est Creteil, INSERM, IMRB, Creteil, France.
  6. EFS, IMRB, Creteil, France.
  7. Institut Pasteur, Unité de Virologie Structurale - CNRS, UMR3569, Paris, France.
PMID 32904469 2020 One Health eng ppublish
PubMed DOI Browse context

Article

Publication summary

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan, China, in 2019, is responsible for the COVID-19 pandemic. It is now accepted that the wild fauna, probably bats, constitute the initial reservoir of the virus, but little is known about the role pets can play in the spread of the disease in human communities, knowing the ability of SARS-CoV-2 to infect some domestic animals. In this cross-sectional study, we tested the antibody response in a cluster of 21 domestic pets (9 cats and 12 dogs) living in close contact with their owners (belonging to a veterinary community of 20 students) in which two students tested positive for COVID-19 and several others (<i>n</i> = 11/18) consecutively showed clinical signs (fever, cough, anosmia, <i>etc.</i>) compatible with COVID-19 infection. Although a few pets presented many clinical signs indicative for a coronavirus infection, no antibodies against SARS-CoV-2 were detectable in their blood one month after the index case was reported, using an immunoprecipitation assay. These original data can serve a better evaluation of the host range of SARS-CoV-2 in natural environment exposure conditions.

Canine COVID-19 epidemiology Feline LIPS Luciferase immunoprecipitation system Outbreak Self-isolation

Structured evidence records

Evidence records

4 total
Host Range Experiment 2 records
Host Range Experiment Extraction confidence 0.75
Key finding

Cats and dogs exposed to COVID-19-positive humans showed no detectable antibodies to SARS-CoV-2, indicating lack of infection under natural exposure conditions.

Virus
SARS-CoV-2
Location
Not specified
Supporting text

In this cross-sectional study, we tested the antibody response in a cluster of 21 domestic pets (9 cats and 12 dogs) living in close contact with their owners ... Although a few pets presented many clinical signs indicative for a coronavirus infection, no antibodies against SARS-CoV-2 were detectable in their blood one month after the index case was reported, using an immunoprecipitation assay.

Method
antibody testing; immunoprecipitation assay
Sample type
blood
Experimental system
in vivo animal experiment
Host Range Experiment Extraction confidence 0.75
Key finding

Dogs exposed to COVID-19-positive humans showed no detectable antibodies to SARS-CoV-2, indicating absence of infection under natural exposure conditions.

Virus
SARS-CoV-2
Location
Not specified
Supporting text

In this cross-sectional study, we tested the antibody response in a cluster of 21 domestic pets (9 cats and 12 dogs) living in close contact with their owners ... Although a few pets presented many clinical signs indicative for a coronavirus infection, no antibodies against SARS-CoV-2 were detectable in their blood one month after the index case was reported, using an immunoprecipitation assay.

Method
antibody testing; immunoprecipitation assay
Sample type
blood
Experimental system
in vivo animal experiment
Serological Evidence 1 records
Serological Evidence Extraction confidence 0.95
Key finding

Cats and dogs exposed to COVID-19 patients had no detectable SARS-CoV-2 antibodies in blood by immunoprecipitation assay.

Virus
SARS-CoV-2
Location
Not specified
Supporting text

Although a few pets presented many clinical signs indicative for a coronavirus infection, no antibodies against SARS-CoV-2 were detectable in their blood one month after the index case was reported, using an immunoprecipitation assay.

Method
immunoprecipitation assay
Sample type
blood
Spillover Event 1 records
Spillover Event Extraction confidence 0.80
Key finding

Cats and dogs exposed to COVID-19 positive humans showed no detectable SARS-CoV-2 antibodies, indicating absence of human-to-animal spillback under the studied conditions.

Virus
SARS-CoV-2
Location
veterinary campus
Supporting text

In this cross-sectional study, we tested the antibody response in a cluster of 21 domestic pets (9 cats and 12 dogs) living in close contact with their owners (belonging to a veterinary community of 20 students) in which two students tested positive for COVID-19 ... no antibodies against SARS-CoV-2 were detectable in their blood one month after the index case was reported.

Method
antibody testing; immunoprecipitation assay
Study design
cross-sectional study
Transmission direction
human-to-animal
Geographic raw
veterinary campus