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Literature detail

Achimota Pararubulavirus 3: A New Bat-Derived Paramyxovirus of the Genus <i>Pararubulavirus</i>.

Kate S Baker1,2,3 Mary Tachedjian4 Jennifer Barr4 Glenn A Marsh4 Shawn Todd4 Gary Crameri4 Sandra Crameri4 Ina Smith5 Clare E G Holmes4 Richard Suu-Ire6,7 Andres Fernandez-Loras2 Andrew A Cunningham2 James L N Wood1 Lin-Fa Wang4,8
Affiliations 8 institutions
  1. Department of Veterinary Medicine, University of Cambridge, Madingley Rd, Cambridge, Cambridgeshire CB3 0ES, UK.
  2. Institute of Zoology, Zoological Society of London, London, NW1 4RY, UK.
  3. Institute for Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L69 7ZB, UK.
  4. CSIRO Health and Biosecurity, Australian Animal Health Laboratory, Portarlington Road, East Geelong, Victoria 3220, Australia.
  5. CSIRO Health & Biosecurity, Clunies Ross Street, Black Mountain, ACT 2601, Australia.
  6. Wildlife Division of the Forestry Commission, Accra P.O. Box M239, Ghana.
  7. Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.
  8. Programme in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore 169857, Singapore.
PMID 33143230 2020 Viruses eng epublish
PubMed DOI Browse context

Article

Publication summary

Bats are an important source of viral zoonoses, including paramyxoviruses. The paramyxoviral <i>Pararubulavirus</i> genus contains viruses mostly derived from bats that are common, diverse, distributed throughout the Old World, and known to be zoonotic. Here, we describe a new member of the genus Achimota pararubulavirus 3 (AchPV3) and its isolation from the urine of African straw-coloured fruit bats on primary bat kidneys cells. We sequenced and analysed the genome of AchPV3 relative to other <i>Paramyxoviridae</i>, revealing it to be similar to known pararubulaviruses. Phylogenetic analysis of AchPV3 revealed the failure of molecular detection in the urine sample from which AchPV3 was derived and an attachment protein most closely related with AchPV2-a pararubulavirus known to cause cross-species transmission. Together these findings add to the picture of pararubulaviruses, their sources, and variable zoonotic potential, which is key to our understanding of host restriction and spillover of bat-derived paramyxoviruses. AchPV3 represents a novel candidate zoonosis and an important tool for further study.

bat electron microscopy genomics molecular detection paramyxovirus pararubulavirus primary cell lines virus virus discovery zoonosis Phylogeny Animals Cells, Cultured Chiroptera Chlorocebus aethiops Genome, Viral Kidney Paramyxoviridae Infections

Structured evidence records

Evidence records

2 total
Genomic Evolution 1 records
Genomic Evolution Extraction confidence 0.85
Key finding

Genome sequencing and phylogenetic analysis showed AchPV3 is closely related to pararubulaviruses such as AchPV2, indicating evolutionary relatedness among bat-derived paramyxoviruses.

Virus
AchPV3
Location
Not specified
Supporting text

We sequenced and analysed the genome of AchPV3 relative to other Paramyxoviridae, revealing it to be similar to known pararubulaviruses. Phylogenetic analysis of AchPV3 revealed an attachment protein most closely related with AchPV2—a pararubulavirus known to cause cross-species transmission.

Genes or proteins
attachment protein; whole genome
Analysis methods
genome sequencing; phylogenetic analysis
Zoonotic Surveillance 1 records
Zoonotic Surveillance Extraction confidence 0.90
Key finding

A novel paramyxovirus, Achimota pararubulavirus 3, was isolated from the urine of African straw-coloured fruit bats, representing active viral surveillance in bat populations.

Virus
AchPV3
Location
Africa
Supporting text

We describe a new member of the genus Achimota pararubulavirus 3 (AchPV3) and its isolation from the urine of African straw-coloured fruit bats on primary bat kidneys cells.

Method
virus isolation; whole genome sequencing; molecular detection
Sample type
urine
Geographic raw
Africa