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Literature detail

SARS-CoV-2 Seroprevalence in Household Domestic Ferrets (<i>Mustela putorius furo</i>).

Jacobo Giner1,2 Sergio Villanueva-Saz3,4,5 Ana Pilar Tobajas5,6 María Dolores Pérez5,6 Ana González2 Maite Verde2,3,5 Andrés Yzuel3 Ana García-García7 Víctor Taleb7 Erandi Lira-Navarrete7 Ramón Hurtado-Guerrero7,8,9,10 Julián Pardo8,11,12 Llipsy Santiago11 José Ramón Paño13 Héctor Ruíz2 Delia Lacasta2,5 Antonio Fernández2,3,5
Affiliations 13 institutions
  1. Menescalia Veterinary Clinic, 46020 Valencia, Spain.
  2. Department of Animal Pathology, Veterinary Faculty, University of Zaragoza, 50009 Zaragoza, Spain.
  3. Clinical Immunology Laboratory, Veterinary Faculty, University of Zaragoza, 50009 Zaragoza, Spain.
  4. Departament of Pharmacology and Physiology, Veterinary Faculty, University of Zaragoza, 50009 Zaragoza, Spain.
  5. Instituto Agroalimentario de Aragón-IA2, University of Zaragoza, 50009 Zaragoza, Spain.
  6. Department of Animal Production and Sciences of the Food, Veterinary Faculty, University of Zaragoza, 50009 Zaragoza, Spain.
  7. Institute for Biocomputation and Physics of Complex Systems (BIFI), Mariano Esquillor s/n, Campus Rio Ebro, Edificio I+D, University of Zaragoza, 50009 Zaragoza, Spain.
  8. Aragon I+D Foundation (ARAID), 50018 Zaragoza, Spain.
  9. Laboratorio de Microscopías Avanzada (LMA), Mariano Esquillor s/n, Campus Rio Ebro, Edificio I+D, 50018 Zaragoza, Spain.
  10. Department of Cellular and Molecular Medicine, School of Dentistry, University of Copenhagen, 1165 Copenhagen, Denmark.
  11. Aragon Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain.
  12. Department of Microbiology, Pediatrics, Radiology and Public Health, University of Zaragoza, 50009 Zaragoza, Spain.
  13. Infectious Disease Department, University Hospital Lozano Blesa, 50009 Zaragoza, Spain.
PMID 33801548 2021 Animals (Basel) eng epublish
PubMed DOI Browse context

Article

Publication summary

Animal infections with SARS-CoV-2 have been reported in different countries and several animal species have been proven to be susceptible to infection with SARS-CoV-2 both naturally and by experimental infection. Moreover, infections under natural conditions in more than 20 mink farms have been reported where humans could have been the source of infection for minks. However, little information is available about the susceptibility of pet animals under natural conditions and currently there is no SARS-CoV-2 epidemiological assessment occurrence in household ferrets. In this study, the presence of SARS-CoV-2 antibodies was evaluated in serum samples obtained from 127 household ferrets (<i>Mustela putorius furo</i>) in the Province of Valencia (Spain). Two ferrets tested positive to SARS-CoV-2 (1.57%) by in-house enzyme-linked immunosorbent assay based on receptor binding domain (RBD) of Spike antigen. Furthermore, anti-RBD SARS-CoV-2 antibodies persisted at detectable levels in a seropositive SARS-CoV-2 domestic ferret beyond 129 days since the first time antibodies were detected. This study reports for the first time the evidence of household pet ferrets exposure to SARS-CoV-2 in Spain to date.

coronavirus disease 2019 (COVID-19) ELISA household ferrets SARS-CoV-2 serology

Structured evidence records

Evidence records

2 total
Serological Evidence 1 records
Serological Evidence Extraction confidence 1.00
Key finding

Two of 127 household ferrets in Spain were seropositive for SARS-CoV-2 antibodies by ELISA, showing evidence of natural exposure.

Virus
SARS-CoV-2
Location
Not specified
Supporting text

The presence of SARS-CoV-2 antibodies was evaluated in serum samples obtained from 127 household ferrets (Mustela putorius furo) in the Province of Valencia (Spain). Two ferrets tested positive to SARS-CoV-2 (1.57%) by in-house enzyme-linked immunosorbent assay based on receptor binding domain (RBD) of Spike antigen.

Method
enzyme-linked immunosorbent assay (ELISA)
Sample type
serum
Spillover Event 1 records
Spillover Event Extraction confidence 0.80
Key finding

SARS-CoV-2 antibodies were detected in domestic ferrets from private households in Spain, indicating human-to-ferret transmission.

Virus
SARS-CoV-2
Location
Spain Province of Valencia (Spain), Spain
Supporting text

Two ferrets tested positive to SARS-CoV-2 (1.57%) by in-house enzyme-linked immunosorbent assay based on receptor binding domain (RBD) of Spike antigen. This study reports for the first time the evidence of household pet ferrets exposure to SARS-CoV-2 in Spain.

Method
enzyme-linked immunosorbent assay (ELISA)
Study design
serological survey
Transmission direction
human-to-animal
Geographic raw
Province of Valencia (Spain)
Country inferred
Spain