OmniVira

Literature detail

Lack of Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spillover in Free-Living Neotropical Non-Human Primates, Brazil.

Lívia Sacchetto1 Bárbara Aparecida Chaves2,3,4 Edson Rodrigues Costa2 Aline Souza de Menezes Medeiros2 Marcelo Gordo5 Danielle Bastos Araújo6,7 Danielle Bruna Leal Oliveira6,7,8 Ana Paula Betaressi da Silva9 Andréia Francesli Negri9 Edison Luiz Durigon6,10 Kathryn A Hanley11 Nikos Vasilakis12,13,14,15,16 Marcus Vinícius Guimarães de Lacerda2,3,17 Maurício Lacerda Nogueira1
Affiliations 17 institutions
  1. Laboratório de Pesquisas em Virologia, Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto 15090-000, Brazil.
  2. Instituto de Pesquisas Clínicas Carlos Borborema, Fundação de Medicina Tropical Doutor Heitor Vieria Dourado, Manaus 69040-000, Brazil.
  3. Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69040-000, Brazil.
  4. Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Amazonas, Manaus 69020-160, Brazil.
  5. Laboratório de Biologia da Conservação, Projeto Sauim-de-Coleira, Instituto de Ciências Biológicas, Universidade Federal do Amazonas, PPGZOO, PPGCASA, CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), Manaus 69080-900, Brazil.
  6. Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-000, Brazil.
  7. Hospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.
  8. Centro de Inovação e Desenvolvimento, Instituto Butantã, São Paulo 05503-900, Brazil.
  9. Departamento de Vigilância Epidemiológica de São José do Rio Preto, São José do Rio Preto 15084-010, Brazil.
  10. Plataforma Científica Pasteur, Universidade de São Paulo, São Paulo 05508-020, Brazil.
  11. Department of Biology, New Mexico State University, Las Cruces, NM 88003, USA.
  12. Department of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
  13. Sealy Center for Vector-Borne and Zoonotic Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA.
  14. Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA.
  15. Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA.
  16. Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA.
  17. Instituto Leônidas e Maria Deane, Fiocruz, Manaus 69057-070, Brazil.
PMID 34696363 2021 Viruses eng epublish
PubMed DOI Browse context

Article

Publication summary

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent of coronavirus disease 2019 (COVID-19)<b>,</b> is responsible for the worst pandemic of the 21st century. Like all human coronaviruses, SARS-CoV-2 originated in a wildlife reservoir, most likely from bats. As SARS-CoV-2 has spread across the globe in humans, it has spilled over to infect a variety of non-human animal species in domestic, farm, and zoo settings. Additionally, a broad range of species, including one neotropical monkey, have proven to be susceptible to experimental infection with SARS-CoV-2. Together, these findings raise the specter of establishment of novel enzootic cycles of SARS-CoV-2. To assess the potential exposure of free-living non-human primates to SARS-CoV-2, we sampled 60 neotropical monkeys living in proximity to Manaus and São José do Rio Preto, two hotspots for COVID-19 in Brazil. Our molecular and serological tests detected no evidence of SAR-CoV-2 infection among these populations. While this result is reassuring, sustained surveillance efforts of wildlife living in close association with human populations is warranted, given the stochastic nature of spillover events and the enormous implications of SARS-CoV-2 spillover for human health.

coronavirus COVID-19 emerging virus non-human primates spillback Alouatta Animals Animals, Wild Brazil Callicebus Callithrix COVID-19 Epidemiological Monitoring Pandemics Primates SARS-CoV-2 Viral Zoonoses

Structured evidence records

Evidence records

2 total
Serological Evidence 1 records
Serological Evidence Extraction confidence 0.90
Key finding

Serological testing of 60 free-living neotropical monkeys in Brazil showed no evidence of SARS-CoV-2 antibodies or infection.

Virus
SARS-CoV-2
Host
Primates
Location
Not specified
Supporting text

To assess the potential exposure of free-living non-human primates to SARS-CoV-2, we sampled 60 neotropical monkeys ... Our molecular and serological tests detected no evidence of SARS-CoV-2 infection among these populations.

Method
serological test
Sample type
serum
Zoonotic Surveillance 1 records
Zoonotic Surveillance Extraction confidence 0.95
Key finding

Molecular and serological surveillance of free-living neotropical non-human primates in Brazil found no evidence of SARS-CoV-2 infection.

Virus
SARS-CoV-2
Host
Primates
Location
Brazil Manaus and São José do Rio Preto, Brazil
Supporting text

To assess the potential exposure of free-living non-human primates to SARS-CoV-2, we sampled 60 neotropical monkeys living in proximity to Manaus and São José do Rio Preto, two hotspots for COVID-19 in Brazil. Our molecular and serological tests detected no evidence of SARS-CoV-2 infection among these populations.

Method
molecular test; serological test
Geographic raw
Manaus and São José do Rio Preto
Country inferred
Brazil