Article
Publication summary
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Literature detail
Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin.
Structured evidence records
Evidence records
Cross Species Transmission
1 records
Cross Species Transmission
Extraction confidence 0.85
Key finding
Study investigates molecular interactions that enable SARS-CoV-2-like viruses of pangolin origin to interact with ACE2 from multiple animal species, indicating potential non-human cross-species transmission.
Virus
Host
Location
Supporting text
Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin.
- Method
- ACE2 binding assay; molecular modeling
- Study design
- molecular interaction analysis
- Transmission direction
- animal-to-animal
Molecular Adaptation
1 records
Molecular Adaptation
Extraction confidence 0.80
Key finding
The study examines molecular mechanisms underlying ACE2 receptor binding adaptation between pangolin-origin SARS-CoV-2-like viruses and other species.
Virus
Host
Location
Supporting text
Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin.
- Genes or proteins
- ACE2; spike
- Receptors
- ACE2
- Mechanism types
- receptor_binding; cell_entry; host_factor_interaction
Receptor Usage
1 records
Receptor Usage
Extraction confidence 0.95
Key finding
SARS-CoV-2-like viruses derived from pangolins were studied for their ability to bind ACE2 receptors from multiple species, providing molecular evidence of receptor-mediated cross-species compatibility.
Virus
Host
Location
Supporting text
The title indicates analysis of 'cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin', demonstrating receptor binding and compatibility studies involving ACE2 receptors.
- Receptors
- ACE2
Citation context
References
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| PMID 34139177 In OmniVira | Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species. | Liu | 2021 |
| PMID 32841599 In OmniVira | Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding. | Starr | 2020 |
| PMID 34400835 | SARS‐CoV‐2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution | Zahradník | 2021 |