OmniVira

Literature detail

SARS-CoV-2 Omicron emergence urges for reinforced One-Health surveillance.

Xavier Montagutelli1 Sylvie van der Werf2,3 Felix A Rey4 Etienne Simon-Loriere5
Affiliations 5 institutions
  1. Mouse Genetics Laboratory, Institut Pasteur, Université de Paris, Paris, France.
  2. Molecular Genetics of RNA Viruses Unit, CNRS UMR 3569, Institut Pasteur, Université de Paris, Paris, France.
  3. National Reference Center for Respiratory Viruses, Institut Pasteur, Université de Paris, Paris, France.
  4. Structural Virology Unit, CNRS UMR 3569, Institut Pasteur, Université de Paris, Paris, France.
  5. G5 Evolutionary Genomics of RNA Viruses, Institut Pasteur, Université de Paris, Paris, France.
PMID 35083854 2022 EMBO Mol Med eng ppublish
PubMed DOI Browse context

Article

Publication summary

SARS-CoV-2 Omicron harbors substitutions in the receptor binding domain of the spike which strongly suggest its capacity to infect rodents. Wild animal reservoirs could favor the emergence of new variants with risks of spillback to humans and should be closely monitored.

COVID-19 One Health Animals Humans Population Surveillance Protein Binding SARS-CoV-2 Spike Glycoprotein, Coronavirus spike protein, SARS-CoV-2

Structured evidence records

Evidence records

2 total
Molecular Adaptation 1 records
Molecular Adaptation Extraction confidence 0.80
Key finding

Omicron variant of SARS-CoV-2 contains receptor-binding domain substitutions in the spike protein that may permit infection of rodents, indicating molecular adaptation to a new host.

Virus
SARS-CoV-2
Host
Not specified
Location
Not specified
Supporting text

SARS-CoV-2 Omicron harbors substitutions in the receptor binding domain of the spike which strongly suggest its capacity to infect rodents.

Genes or proteins
spike
Mechanism types
receptor_binding; host_range_adaptation
Zoonotic Surveillance 1 records
Zoonotic Surveillance Extraction confidence 0.75
Key finding

The study calls for close monitoring of wild animal reservoirs for SARS-CoV-2 to detect potential emergence of new variants.

Virus
SARS-CoV-2
Host
Not specified
Location
Not specified
Supporting text

Wild animal reservoirs could favor the emergence of new variants with risks of spillback to humans and should be closely monitored.