Recent evidence findings
Synthesizing linked evidence and source literature...
Generating an evidence-grounded brief with GPT-5... AI-assisted synthesis grounded in linked OVE records and source literature. Verify details against the cited evidence.
10 source articles
13 hosts
8 countries
| Publication date | Category / type | Key finding | PMID |
|---|---|---|---|
| 2026-08-10 | Functional Mechanism Molecular Adaptation | Deletion of 3'UTR SLI and/or SLIII in TMUV impairs replication in avian cells but not mammalian cells, and dual deletion reduces virulence in ducklings with limited impact in mice. | 42578371 |
| 2026-08-10 | Functional Mechanism Molecular Adaptation | TMUV 3'UTR SLI/SLIII promote replication in avian cells via interaction with the host factor CELF2. | 42578371 |
| 2026-08-10 | Functional Mechanism Molecular Adaptation | Duplication of SLII in the TMUV 3'UTR enhances replication in mammalian and avian cells but not mosquito cells, indicating host-specific proliferation effects. | 42578371 |
| 2026-08-10 | Functional Mechanism Molecular Adaptation | Replacing JEV SLI/SLIII with homologous elements from a duck-associated strain increases JEV proliferation in avian cells. | 42578371 |
| 2026-08-10 | Functional Mechanism Molecular Adaptation | TMUV mutants retaining only one 3'UTR stem-loop are replication-attenuated, with efficiency dependent on which SL is retained. | 42578371 |
| 2026-07-29 | Experimental Infection Pathogenicity Experiment | Chicken-derived TMUV isolate WH2025 (cluster 3.2) caused 100% mortality in experimentally infected mice, indicating highest pathogenicity among tested isolates. | 42523112 |
| 2026-07-29 | Experimental Infection Host Range Experiment | Five TMUV isolates from clusters 2.1.1, 2.1.2, 2.2, 3.1, and 3.2 were experimentally tested in mice to assess mammalian pathogenicity; the chicken-derived cluster 3.2 isolate WH2025 caused 100% mortality. | 42523112 |
| 2026-07-29 | Experimental Infection Host Range Experiment | In Culex quinquefasciatus, contemporary duck-derived TMUV isolates from clusters 2 and 3.2 replicated and infected more efficiently than the ancestral mosquito-derived isolate MM 1775 (cluster 3.1). | 42523112 |
| 2026-07-28 | Zoonotic Surveillance Viral Detection | Metagenomic sequencing of pooled sylvatic Diptera from Alto Pantanal, Brazil recovered 39 putative viral sequences, including coding-complete and partial genomes from multiple viral families. | 42521068 |
| 2026-07-28 | Zoonotic Surveillance Viral Detection | Partial genomes from multiple virus families, including Flaviviridae, were recovered from the Diptera pools. | 42521068 |
| 2026-07-17 | Functional Mechanism Molecular Adaptation | Host splicing factor domains U2AF1 RS and Zn1, and nearly all domains of U2AF2 except its RS domain, are required for proviral function during orthoflavivirus infection. | 42464737 |
| 2026-07-17 | Experimental Infection Host Range Experiment | Trans-complementation with the Aedes aegypti homolog u2af38 in U2AF1-knockout cells restores ZIKV replication, indicating cross-species functional support for infection. | 42464737 |
| 2026-07-17 | Functional Mechanism Molecular Adaptation | Host factors U2AF1 and U2AF2 bind viral RNA, with U2AF1 binding dependent on U2AF2, supporting a mechanistic role in viral protein synthesis/replication. | 42464737 |
| 2026-07-17 | Experimental Infection Host Range Experiment | Knockdown of either u2af38 or u2af50 in mosquitoes significantly inhibited flavivirus replication. | 42464737 |
| 2026-07-17 | Functional Mechanism Molecular Adaptation | A truncated cytoplasmic form of the host factor U2AF2 is sufficient to support flavivirus replication. | 42464737 |
| 2026-07-17 | Experimental Infection Host Range Experiment | Expressing Aedes aegypti u2af50 in U2AF2-knockdown cells did not restore ZIKV replication. | 42464737 |
| 2026-07-17 | Experimental Infection Host Range Experiment | U2AF2 and U2AF1 are critical host factors for efficient infection by Dengue virus and Zika virus at the viral protein synthesis stage in infected cells. | 42464737 |
| 2026-07-17 | Experimental Infection Host Range Experiment | Disrupting the U2AF1–U2AF2 interaction potently suppresses ZIKV infection in cells. | 42464737 |
| 2026-06-25 | Experimental Infection Pathogenicity Experiment | Louping ill virus caused fever, clinical signs, high viral loads, and brain tropism in experimentally infected sheep, whereas tick‑borne encephalitis virus produced no clinical signs and limited replication. | 42345572 |
| 2026-06-25 | Zoonotic Surveillance Virus Isolation | Infectious Louping ill virus was isolated from serum and multiple tissues of experimentally infected sheep, confirming recovery of viable virus. | 42345572 |
| 2026-06-25 | Zoonotic Surveillance Viral Detection | Tick-borne encephalitis virus RNA was detected at low levels in the skin, prescapular lymph nodes, and spleen of experimentally infected sheep. | 42345572 |
| 2026-06-05 | Genomic Evolution Phylogenetic Evolution | Phylogenetic analysis of complete Jingmen tick virus (JMTV) genomes identified two well-supported global clades and indicated geographic partitioning of viral diversity. | 42263510 |
| 2026-06-05 | Zoonotic Surveillance Viral Detection | Metagenomic screening detected Jingmen tick virus signals in 32.9% of pooled tick samples collected from Kenya, Belize, and the United States. | 42263510 |
| 2026-06-03 | Zoonotic Surveillance Serological Evidence | Neutralizing antibodies to Jingmen tick virus were confirmed in livestock, a human, and a rat in Pakistan, supporting cross-species exposure to this virus. | 42242448 |
| 2026-06-03 | Zoonotic Surveillance Serological Evidence | Serological surveys detected antibodies against Jingmen tick virus, brown dog tick phlebovirus 2, and Liman tick virus in livestock, humans, and rats in Pakistan, indicating host exposure. | 42242448 |
| 2026-06-03 | Zoonotic Surveillance Viral Detection | Metagenomic sequencing detected sequences of Jingmen tick virus in ticks associated with livestock in Punjab, Pakistan. | 42242448 |
| 2026-06-02 | Genomic Evolution Phylogenetic Evolution | Phylogenetic analysis showed that JMTV from Costa Rica shares a common ancestor with Caribbean and Latin American strains and clusters with viruses detected in humans from Europe and Western Asia. | 42126202 |
| 2026-06-02 | Zoonotic Surveillance Viral Detection | Jingmen tick virus was detected in host-feeding Amblyomma mixtum ticks collected from horses in Costa Rica. | 42126202 |
| 2026-06-02 | Genomic Evolution Phylogenetic Evolution | Two distinct clades of Jingmenviruses were identified in the Americas, indicating two separate introductions from Europe/Asia and Africa/Asia. | 42126202 |
| 2026-06 | Zoonotic Surveillance Viral Detection | Usutu virus RNA was molecularly detected in six wild blackbirds collected in Barcelona province during 2022, 2024, and 2025. | 42004747 |
| 2026-06 | Genomic Evolution Phylogenetic Evolution | Phylogeographic analysis traced the origin of the European West Nile virus lineage 2 clade to Hungary in 2004, with introduction into Italy between 2009 and 2010 and subsequent spread across Italy during 2022–2023. | 41552429 |
| 2026-06 | Genomic Evolution Phylogenetic Evolution | Phylogenetic analysis showed co-circulation of two distinct Usutu virus lineages, Africa 3 and Europe 2, and revealed overwintering of the virus in northeastern Spain, with lineage Europe 2 detected there for the first time. | 42004747 |
| 2026-06 | Zoonotic Surveillance Reservoir Ecology | Active enzootic circulation of Usutu virus was demonstrated in Northeastern Spain involving wild birds and mosquitoes. | 42004747 |
| 2026-06 | Zoonotic Surveillance Serological Evidence | Sentinel and backyard birds from Girona province showed serological evidence of flavivirus exposure. | 42004747 |
| 2026-06 | Zoonotic Surveillance Viral Detection | West Nile Virus Lineage 1 was detected in two wild bird samples collected in northwestern Italy, including one co-infected with Lineage 2. | 41552429 |
| 2026-06 | Zoonotic Surveillance Viral Detection | West Nile Virus Lineage 2 was detected in wild birds and mosquito pools collected in northwestern Italy between 2022 and 2023. | 41552429 |
| 2026-06 | Genomic Evolution Phylogenetic Evolution | Phylogenetic analyses indicated a natural animal-to-human spillover of Usutu virus in Northeastern Spain. | 42004747 |
| 2026-06 | Zoonotic Surveillance Viral Detection | Usutu virus was detected in a Culex pipiens mosquito pool collected in Catalonia. | 42004747 |
Synthesizing linked evidence and source literature...
Generating an evidence-grounded brief with GPT-5... AI-assisted synthesis grounded in linked OVE records and source literature. Verify details against the cited evidence.
4 source articles
4 hosts
1 countries
| Publication date | Category / type | Key finding | PMID |
|---|---|---|---|
| 2026-08-10 | Functional Mechanism Molecular Adaptation | Deletion of 3'UTR SLI and/or SLIII in TMUV impairs replication in avian cells but not mammalian cells, and dual deletion reduces virulence in ducklings with limited impact in mice. | 42578371 |
| 2026-08-10 | Functional Mechanism Molecular Adaptation | TMUV 3'UTR SLI/SLIII promote replication in avian cells via interaction with the host factor CELF2. | 42578371 |
| 2026-08-10 | Functional Mechanism Molecular Adaptation | Duplication of SLII in the TMUV 3'UTR enhances replication in mammalian and avian cells but not mosquito cells, indicating host-specific proliferation effects. | 42578371 |
| 2026-08-10 | Functional Mechanism Molecular Adaptation | Replacing JEV SLI/SLIII with homologous elements from a duck-associated strain increases JEV proliferation in avian cells. | 42578371 |
| 2026-08-10 | Functional Mechanism Molecular Adaptation | TMUV mutants retaining only one 3'UTR stem-loop are replication-attenuated, with efficiency dependent on which SL is retained. | 42578371 |
| 2026-07-29 | Experimental Infection Pathogenicity Experiment | Chicken-derived TMUV isolate WH2025 (cluster 3.2) caused 100% mortality in experimentally infected mice, indicating highest pathogenicity among tested isolates. | 42523112 |
| 2026-07-29 | Experimental Infection Host Range Experiment | Five TMUV isolates from clusters 2.1.1, 2.1.2, 2.2, 3.1, and 3.2 were experimentally tested in mice to assess mammalian pathogenicity; the chicken-derived cluster 3.2 isolate WH2025 caused 100% mortality. | 42523112 |
| 2026-07-29 | Experimental Infection Host Range Experiment | In Culex quinquefasciatus, contemporary duck-derived TMUV isolates from clusters 2 and 3.2 replicated and infected more efficiently than the ancestral mosquito-derived isolate MM 1775 (cluster 3.1). | 42523112 |
| 2026-07-28 | Zoonotic Surveillance Viral Detection | Metagenomic sequencing of pooled sylvatic Diptera from Alto Pantanal, Brazil recovered 39 putative viral sequences, including coding-complete and partial genomes from multiple viral families. | 42521068 |
| 2026-07-28 | Zoonotic Surveillance Viral Detection | Partial genomes from multiple virus families, including Flaviviridae, were recovered from the Diptera pools. | 42521068 |
| 2026-07-17 | Functional Mechanism Molecular Adaptation | Host splicing factor domains U2AF1 RS and Zn1, and nearly all domains of U2AF2 except its RS domain, are required for proviral function during orthoflavivirus infection. | 42464737 |
| 2026-07-17 | Experimental Infection Host Range Experiment | Trans-complementation with the Aedes aegypti homolog u2af38 in U2AF1-knockout cells restores ZIKV replication, indicating cross-species functional support for infection. | 42464737 |
| 2026-07-17 | Functional Mechanism Molecular Adaptation | Host factors U2AF1 and U2AF2 bind viral RNA, with U2AF1 binding dependent on U2AF2, supporting a mechanistic role in viral protein synthesis/replication. | 42464737 |
| 2026-07-17 | Experimental Infection Host Range Experiment | Knockdown of either u2af38 or u2af50 in mosquitoes significantly inhibited flavivirus replication. | 42464737 |
| 2026-07-17 | Functional Mechanism Molecular Adaptation | A truncated cytoplasmic form of the host factor U2AF2 is sufficient to support flavivirus replication. | 42464737 |
| 2026-07-17 | Experimental Infection Host Range Experiment | Expressing Aedes aegypti u2af50 in U2AF2-knockdown cells did not restore ZIKV replication. | 42464737 |
| 2026-07-17 | Experimental Infection Host Range Experiment | U2AF2 and U2AF1 are critical host factors for efficient infection by Dengue virus and Zika virus at the viral protein synthesis stage in infected cells. | 42464737 |
| 2026-07-17 | Experimental Infection Host Range Experiment | Disrupting the U2AF1–U2AF2 interaction potently suppresses ZIKV infection in cells. | 42464737 |
Synthesizing linked evidence and source literature...
Generating an evidence-grounded brief with GPT-5... AI-assisted synthesis grounded in linked OVE records and source literature. Verify details against the cited evidence.
1 source articles
0 hosts
0 countries
| Publication date | Category / type | Key finding | PMID |
|---|---|---|---|
| 2026-08-10 | Functional Mechanism Molecular Adaptation | Deletion of 3'UTR SLI and/or SLIII in TMUV impairs replication in avian cells but not mammalian cells, and dual deletion reduces virulence in ducklings with limited impact in mice. | 42578371 |
| 2026-08-10 | Functional Mechanism Molecular Adaptation | TMUV 3'UTR SLI/SLIII promote replication in avian cells via interaction with the host factor CELF2. | 42578371 |
| 2026-08-10 | Functional Mechanism Molecular Adaptation | Duplication of SLII in the TMUV 3'UTR enhances replication in mammalian and avian cells but not mosquito cells, indicating host-specific proliferation effects. | 42578371 |
| 2026-08-10 | Functional Mechanism Molecular Adaptation | Replacing JEV SLI/SLIII with homologous elements from a duck-associated strain increases JEV proliferation in avian cells. | 42578371 |
| 2026-08-10 | Functional Mechanism Molecular Adaptation | TMUV mutants retaining only one 3'UTR stem-loop are replication-attenuated, with efficiency dependent on which SL is retained. | 42578371 |