Recent evidence findings
Synthesizing linked evidence and source literature...
Generating an evidence-grounded brief with GPT-5... AI-assisted synthesis grounded in linked OVE records and source literature. Verify details against the cited evidence.
10 source articles
12 hosts
2 countries
| Publication date | Category / type | Key finding | PMID |
|---|---|---|---|
| 2026-10-05 | Functional Mechanism Molecular Adaptation | nsp12 mutations I171V, A185S, R249K, and N611S increased replication in a SARS-CoV-2 replicon in human-cell context. | 42831623 |
| 2026-10-05 | Genomic Evolution Phylogenetic Evolution | Phylogenetic/comparative analysis of 183 bat SARS-related coronavirus nsp12 sequences identified mutation hotspots overlapping variable sites in human SARS-CoV-2 (including P323L), indicating shared functional constraints across hosts. | 42831623 |
| 2026-10-05 | Experimental Infection Host Range Experiment | Specific bat SARS-related coronavirus nsp12 mutations enhanced viral replication in both bat and human cells in controlled assays. | 42831623 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | Eight bat-derived nsp12 mutations increased polymerase activity at 37°C, with several also advantageous at 33°C or 40°C. | 42831623 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | Adaptive nsp12 mutations map to RNA capping and RdRp catalytic core regions without altering remdesivir sensitivity. | 42831623 |
| 2026-10 | Zoonotic Surveillance Serological Evidence | Sera from SARS-CoV-2 convalescent individuals robustly cross-neutralised clade 1 sarbecoviruses and showed limited cross-neutralisation across the broader sarbecovirus sub-genus. | 42821519 |
| 2026-10 | Functional Mechanism Receptor Usage | Clade 1 sarbecoviruses, including SARS-CoV-2 and the BANAL isolates from Laos, show broad ACE2 usage, whereas clade 3 (RhGB07) and clade 5 (Rc-o319) exhibit restricted ACE2 usage. | 42821519 |
| 2026-10 | Experimental Infection Host Range Experiment | Generalist sarbecoviruses maintained broad entry across a diverse mammalian ACE2 panel (human, non-human primate, livestock, rodent, and potential intermediate hosts), whereas specialists like RhGB07 showed more variable phenotypes. | 42821519 |
| 2026-10 | Zoonotic Surveillance Serological Evidence | Monoclonal antibodies derived from COVID-19 vaccinees with breakthrough infections identified epitope classes mediating broader neutralisation. | 42821519 |
| 2026-10 | Functional Mechanism Receptor Usage | SARS-CoV-2 variants, especially Omicron and its sub-lineages, display an expanding or shifting generalist pattern of ACE2 usage. | 42821519 |
| 2026-09-24 | Experimental Infection Pathogenicity Experiment | In K18-hACE2 hamsters, MpCoV-GD caused lung pathology comparable to SARS-CoV-2, with extensive damage to the alveolar parenchyma. | 42782103 |
| 2026-09-24 | Experimental Infection Host Range Experiment | Pangolin sarbecoviruses MpCoV-GX and MpCoV-GD replicate in human cells and organoids, though less efficiently than SARS-CoV-2. | 42782103 |
| 2026-09-24 | Functional Mechanism Receptor Usage | Spike proteins from pangolin sarbecoviruses mediate cell–cell membrane fusion, with MpCoV-GD fusing more strongly than MpCoV-GX but weaker than SARS-CoV-2. | 42782103 |
| 2026-09-08 | Zoonotic Surveillance Serological Evidence | Pre-2019 human sera from wildlife hunter communities in Guinea showed IgG cross-reactivity to SARS-CoV, SARS-CoV-2, and MERS-CoV spike antigens. | 42797820 |
| 2026-09-08 | Zoonotic Surveillance Serological Evidence | A subgroup of human sera from Guinea showed strong binding to both SARS-CoV and MERS-CoV receptor binding domains. | 42797820 |
| 2026-08-31 | Functional Mechanism Receptor Usage | The SARS-CoV-2 Delta variant spike favors multivalent engagement of ACE2 via its three RBDs. | 42671377 |
| 2026-08-31 | Functional Mechanism Molecular Adaptation | Later Omicron variants compensate a shift to predominantly single-site ACE2 engagement by increasing the stability of the RBD–ACE2 bond. | 42671377 |
| 2026-08-31 | Functional Mechanism Receptor Usage | Later Omicron variants of SARS-CoV-2 predominantly use single-site ACE2 interactions, compensated by stronger RBD–ACE2 bond stability. | 42671377 |
| 2026-08-31 | Functional Mechanism Molecular Adaptation | Spike conformational plasticity evolved from flexible early strains to rigidified Delta, fluctuating in Omicron, and compact JN.1, balancing receptor accessibility, mobility, and immune escape while maintaining entry efficiency. | 42671377 |
| 2026-08-21 | Experimental Infection Host Range Experiment | RhGB01 and BM48-31 spikes utilized only Rhinolophus blasii ACE2 in entry assays. | 42627230 |
| 2026-08-21 | Functional Mechanism Receptor Usage | ACE2 residues 31 and 41 modulate sarbecovirus spike–ACE2 interactions. | 42627230 |
| 2026-08-21 | Experimental Infection Host Range Experiment | Cloned African Rhinolophus ACE2 variants were tested in a receptor-entry system against a panel of sarbecoviruses to assess susceptibility. | 42627230 |
| 2026-08-21 | Functional Mechanism Receptor Usage | Specific ACE2 residues govern SARS-CoV-2 spike–ACE2 interactions and shape infectivity differences across species. | 42627230 |
| 2026-08-12 | Zoonotic Surveillance Reservoir Ecology | European hedgehogs were concluded to be unlikely maintenance hosts for SARS-CoV-2. | 42612403 |
| 2026-07-29 | Zoonotic Surveillance Viral Detection | SARS-CoV-2 RNA was detected in three white-tailed deer in Massachusetts and Vermont. | 42655652 |
| 2026-07-29 | Zoonotic Surveillance Serological Evidence | ELISA detected SARS-CoV-2–reactive sera in nine wild animals across Eastern cottontail, Eastern coyote, and raccoon, indicating prior exposure. | 42655652 |
| 2026-07-29 | Zoonotic Surveillance Serological Evidence | Neutralizing antibodies to the SARS-CoV-2 Omicron variant were detected in a single Eastern cottontail. | 42655652 |
| 2026-07-29 | Transmission Evidence Cross-species Transmission | Phylogeographic relatedness of Vermont sequences supports a possible human-to–white-tailed deer SARS-CoV-2 spillover. | 42655652 |
| 2026-07-29 | Genomic Evolution Phylogenetic Evolution | Vermont white-tailed deer SARS-CoV-2 genomes are closely related to contemporaneous human sequences from the same region, indicating recent human–deer lineage linkage. | 42655652 |
| 2026-07-21 | Functional Mechanism Molecular Adaptation | Several Guangdong pangolin coronaviruses carry a lysine substitution at spike residue 519 that confers marked immune evasion by modulating spike conformational state. | 42267927 |
| 2026-07-21 | Functional Mechanism Molecular Adaptation | SARS-CoV-2 acquired a divergent immune-evasive mutation at spike residue 519. | 42267927 |
| 2026-07 | Experimental Infection Host Range Experiment | Seasonal influenza A H1N1, H3N2, influenza B, MERS-CoV, and SARS-CoV productively replicated and infected human bronchial tissues in an ex vivo model. | 42397692 |
| 2026-07 | Experimental Infection Pathogenicity Experiment | In an in vitro human alveolar model, HPAI H5N1, H7N9, MERS-CoV, and SARS-CoV caused more severe impairment of alveolar fluid clearance than seasonal H1N1, H3N2, and influenza B viruses. | 42397692 |
Synthesizing linked evidence and source literature...
Generating an evidence-grounded brief with GPT-5... AI-assisted synthesis grounded in linked OVE records and source literature. Verify details against the cited evidence.
3 source articles
7 hosts
0 countries
| Publication date | Category / type | Key finding | PMID |
|---|---|---|---|
| 2026-10-05 | Functional Mechanism Molecular Adaptation | nsp12 mutations I171V, A185S, R249K, and N611S increased replication in a SARS-CoV-2 replicon in human-cell context. | 42831623 |
| 2026-10-05 | Genomic Evolution Phylogenetic Evolution | Phylogenetic/comparative analysis of 183 bat SARS-related coronavirus nsp12 sequences identified mutation hotspots overlapping variable sites in human SARS-CoV-2 (including P323L), indicating shared functional constraints across hosts. | 42831623 |
| 2026-10-05 | Experimental Infection Host Range Experiment | Specific bat SARS-related coronavirus nsp12 mutations enhanced viral replication in both bat and human cells in controlled assays. | 42831623 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | Eight bat-derived nsp12 mutations increased polymerase activity at 37°C, with several also advantageous at 33°C or 40°C. | 42831623 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | Adaptive nsp12 mutations map to RNA capping and RdRp catalytic core regions without altering remdesivir sensitivity. | 42831623 |
| 2026-10 | Zoonotic Surveillance Serological Evidence | Sera from SARS-CoV-2 convalescent individuals robustly cross-neutralised clade 1 sarbecoviruses and showed limited cross-neutralisation across the broader sarbecovirus sub-genus. | 42821519 |
| 2026-10 | Functional Mechanism Receptor Usage | Clade 1 sarbecoviruses, including SARS-CoV-2 and the BANAL isolates from Laos, show broad ACE2 usage, whereas clade 3 (RhGB07) and clade 5 (Rc-o319) exhibit restricted ACE2 usage. | 42821519 |
| 2026-10 | Experimental Infection Host Range Experiment | Generalist sarbecoviruses maintained broad entry across a diverse mammalian ACE2 panel (human, non-human primate, livestock, rodent, and potential intermediate hosts), whereas specialists like RhGB07 showed more variable phenotypes. | 42821519 |
| 2026-10 | Zoonotic Surveillance Serological Evidence | Monoclonal antibodies derived from COVID-19 vaccinees with breakthrough infections identified epitope classes mediating broader neutralisation. | 42821519 |
| 2026-10 | Functional Mechanism Receptor Usage | SARS-CoV-2 variants, especially Omicron and its sub-lineages, display an expanding or shifting generalist pattern of ACE2 usage. | 42821519 |
| 2026-09-24 | Experimental Infection Pathogenicity Experiment | In K18-hACE2 hamsters, MpCoV-GD caused lung pathology comparable to SARS-CoV-2, with extensive damage to the alveolar parenchyma. | 42782103 |
| 2026-09-24 | Experimental Infection Host Range Experiment | Pangolin sarbecoviruses MpCoV-GX and MpCoV-GD replicate in human cells and organoids, though less efficiently than SARS-CoV-2. | 42782103 |
| 2026-09-24 | Functional Mechanism Receptor Usage | Spike proteins from pangolin sarbecoviruses mediate cell–cell membrane fusion, with MpCoV-GD fusing more strongly than MpCoV-GX but weaker than SARS-CoV-2. | 42782103 |
Synthesizing linked evidence and source literature...
Generating an evidence-grounded brief with GPT-5... AI-assisted synthesis grounded in linked OVE records and source literature. Verify details against the cited evidence.
1 source articles
4 hosts
0 countries
| Publication date | Category / type | Key finding | PMID |
|---|---|---|---|
| 2026-10-05 | Functional Mechanism Molecular Adaptation | nsp12 mutations I171V, A185S, R249K, and N611S increased replication in a SARS-CoV-2 replicon in human-cell context. | 42831623 |
| 2026-10-05 | Genomic Evolution Phylogenetic Evolution | Phylogenetic/comparative analysis of 183 bat SARS-related coronavirus nsp12 sequences identified mutation hotspots overlapping variable sites in human SARS-CoV-2 (including P323L), indicating shared functional constraints across hosts. | 42831623 |
| 2026-10-05 | Experimental Infection Host Range Experiment | Specific bat SARS-related coronavirus nsp12 mutations enhanced viral replication in both bat and human cells in controlled assays. | 42831623 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | Eight bat-derived nsp12 mutations increased polymerase activity at 37°C, with several also advantageous at 33°C or 40°C. | 42831623 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | Adaptive nsp12 mutations map to RNA capping and RdRp catalytic core regions without altering remdesivir sensitivity. | 42831623 |