Recent evidence findings
Generating research brief from recent literature...
Summarizing recent literature with GPT-5... AI-generated summary. Interpret with care and verify against the source literature.
11 literature
17 hosts
4 countries
| Publication date | Type | Key finding | PMID |
|---|---|---|---|
| 2026-06-02 | Host Range Experiment | Antibody-based chimeric receptors enabled efficient infection and replication of diverse sarbecoviruses from animal and clinical sources, demonstrating that receptor specificity can be reprogrammed beyond human ACE2 dependence. | 42230999 |
| 2026-06-02 | Molecular Adaptation | The E7 antibody-derived chimeric receptor recognized conserved epitopes across sarbecoviruses from all clades, providing molecular evidence for cross-sarbecovirus binding breadth. | 42230999 |
| 2026-06 | Zoonotic Surveillance | Roe deer in Sweden tested negative for SARS-CoV-2 RNA during surveillance performed from 2016 to 2022. | 41783616 |
| 2026-05-20 | Serological Evidence | Wild mammals including foxes, badgers, hedgehogs, roe deer, wolf, and rat showed serological evidence of exposure to SARS-CoV-2, confirmed by anti-RBD ELISA. | 42163369 |
| 2026-05-20 | Zoonotic Surveillance | Wild mammals in Northern Italy were monitored for SARS-CoV-2 and other coronaviruses, providing evidence of coronavirus circulation and serological exposure to SARS-CoV-2. | 42163369 |
| 2026-05-13 | Molecular Adaptation | A single amino acid difference in Orf9b between SARS-CoV-2 and RaTG13 acts as a molecular switch, redirecting binding between Tom70 and MTARC2, thereby modulating immune evasion and viral adaptation to human versus bat hosts. | 42134328 |
| 2026-05-13 | Molecular Adaptation | A nonsynonymous mutation in the SARS-CoV-2 nucleocapsid protein enables replication in bat cells expressing human ACE2 and TMPRSS2, highlighting a molecular adaptation influencing cross-species infectivity. | 42134328 |
| 2026-04-25 | Receptor Usage | Khosta-1 sarbecovirus gained capacity for human ACE2 receptor usage and broader ACE2 binding following mutation screening using the RAISE tool. | 42034636 |
| 2026-04-25 | Receptor Usage | Sarbecoviruses PDF-2370 and Khosta-1 possess mutations that confer the ability to utilize human ACE2 and broaden ACE2 receptor binding across species. | 42034636 |
| 2026-04-25 | Molecular Adaptation | The T498Y/W mutations in Khosta-1 enabled adaptation for human ACE2 usage and expanded ACE2 receptor binding breadth. | 42034636 |
| 2026-04-25 | Molecular Adaptation | The T498Y/W mutations in PDF-2370 and Khosta-1 enabled these sarbecoviruses to utilize human ACE2 and expanded their receptor-binding range across species. | 42034636 |
| 2026-04-25 | Genomic Evolution | Mutation analysis of sarbecovirus Khosta-1 showed that changes such as T498Y/W allowed human ACE2 receptor utilization and expansion of host range. | 42034636 |
| 2026-04-25 | Genomic Evolution | Mutation analysis of sarbecoviruses PDF-2370 and Khosta-1 identified amino acid changes T498Y/W that enabled human ACE2 binding and expanded host species potential. | 42034636 |
| 2026-04-22 | Molecular Adaptation | Mutations F294L and A835D in the SHC014-CoV spike glycoprotein confer ACE2-dependent human cell infection, indicating molecular adaptation facilitating cross-species transmission. | 42026866 |
| 2026-04-22 | Receptor Usage | SHC014-CoV uses human ACE2 for cell entry after acquiring F294L and A835D mutations in the spike ectodomain. | 42026866 |
| 2026-04-09 | Receptor Usage | Elk ACE2 weakly binds ancestral and Delta SARS-CoV-2 spike RBDs but strongly binds Alpha, Beta, Gamma, and Omicron RBDs, with structural assays confirming stable complex formation for the Alpha variant. | 41957014 |
| 2026-04-09 | Molecular Adaptation | Elk ACE2 has a K31N substitution that weakens binding to ancestral and Delta SARS-CoV-2 spike RBDs, but viral N501Y mutation in Alpha, Beta, Gamma, and Omicron variants enhances ACE2–spike compatibility. | 41957014 |
| 2026-04-09 | Zoonotic Surveillance | White-tailed deer are recognized as established reservoirs for SARS-CoV-2 in North America. | 41957014 |
| 2026-04-09 | Zoonotic Surveillance | Field surveillance in the United States found only limited SARS-CoV-2 infection among elk, while widespread infections were observed in white-tailed deer. | 41957014 |
| 2026-04-09 | Host Range Experiment | Elk ACE2 supports SARS-CoV-2 viral entry and replication in vitro, indicating species-specific susceptibility distinct from white-tailed deer. | 41957014 |
| 2026-04-03 | Serological Evidence | Serum samples from rodents in rural Yucatan Peninsula, Mexico, showed 23.1% seropositivity for SARS-CoV-2 antibodies by indirect ELISA. | 42043224 |
| 2026-04-03 | Zoonotic Surveillance | Serological surveillance of rodents in rural Yucatan Peninsula, Mexico, detected antibodies indicating SARS-CoV-2 exposure. | 42043224 |
| 2026-04-03 | Spillover Event | Rodents from rural Mexico showed serological evidence of SARS-CoV-2 exposure, indicating possible sporadic human-to-rodent spillback events. | 42043224 |
| 2026-04 | Receptor Usage | Red fox ACE2 acts as a functional receptor for SARS-CoV-2 and PCoV-GD, supporting pseudovirus entry and showing differential binding affinities in SPR assays. | 41960421 |
| 2026-04 | Receptor Usage | BANAL-236 spike-mediated entry into human and Rhinolophus cells requires human ACE2 and TMPRSS2 expression. | 42008572 |
| 2026-04 | Molecular Adaptation | Residue substitutions R417/H498 in PCoV-GD RBD and mutations such as Y453F in SARS-CoV-2 RBD modulate binding affinity to fox ACE2, indicating molecular adaptation of viral spike-RBDs for cross-species receptor recognition. | 41960421 |
| 2026-04 | Spillover Event | Detection of SARS-CoV-2 RNA in red foxes shows that foxes were naturally infected, supporting a human-to-animal spillback event. | 41960421 |
| 2026-04 | Molecular Adaptation | Multiple BANAL-236 proteins inhibit interferon production and signaling, showing molecular adaptation for innate immune evasion in human cells. | 42008572 |
| 2026-04 | Molecular Adaptation | BANAL-236 spike protein mediates cell entry through human ACE2 and TMPRSS2, indicating receptor-binding adaptation that may facilitate human infection. | 42008572 |
| 2026-04 | Host Range Experiment | BANAL-236 replicated in human cells expressing ACE2 and TMPRSS2, showing susceptibility of human cell systems to this bat sarbecovirus. | 42008572 |
| 2026-04 | Host Range Experiment | BANAL-236 failed to replicate in wild-type Rhinolophus cells but replicated in Rhinolophus ferrumequinum cells engineered to express human ACE2 and TMPRSS2, indicating human receptor-dependent host range expansion. | 42008572 |
| 2026-03-25 | Spillover Event | SARS-CoV-2 spread from infected human caretakers to animals in US zoos, representing confirmed human-to-animal spillback events. | 41880766 |
| 2026-03-25 | Zoonotic Surveillance | Animal surveillance data from US zoos confirmed SARS-CoV-2 infections in captive wildlife as part of national monitoring between 2020 and 2023. | 41880766 |
| 2026-03-25 | Genomic Evolution | Comparative genomic and phylogenetic analyses indicated that SARS-CoV-2 infections in zoo animals originated from human variants, with no sustained viral evolution detected in these animal populations. | 41880766 |
| 2026-03-25 | Outbreak Investigation | Confirmed human-to-animal SARS-CoV-2 outbreaks occurred among zoo animals in the United States between 2020 and 2023, with caretakers identified as the main exposure source. | 41880766 |
Generating research brief from recent literature...
Summarizing recent literature with GPT-5... AI-generated summary. Interpret with care and verify against the source literature.
3 literature
6 hosts
2 countries
| Publication date | Type | Key finding | PMID |
|---|---|---|---|
| 2026-06-02 | Host Range Experiment | Antibody-based chimeric receptors enabled efficient infection and replication of diverse sarbecoviruses from animal and clinical sources, demonstrating that receptor specificity can be reprogrammed beyond human ACE2 dependence. | 42230999 |
| 2026-06-02 | Molecular Adaptation | The E7 antibody-derived chimeric receptor recognized conserved epitopes across sarbecoviruses from all clades, providing molecular evidence for cross-sarbecovirus binding breadth. | 42230999 |
| 2026-06 | Zoonotic Surveillance | Roe deer in Sweden tested negative for SARS-CoV-2 RNA during surveillance performed from 2016 to 2022. | 41783616 |
| 2026-05-20 | Serological Evidence | Wild mammals including foxes, badgers, hedgehogs, roe deer, wolf, and rat showed serological evidence of exposure to SARS-CoV-2, confirmed by anti-RBD ELISA. | 42163369 |
| 2026-05-20 | Zoonotic Surveillance | Wild mammals in Northern Italy were monitored for SARS-CoV-2 and other coronaviruses, providing evidence of coronavirus circulation and serological exposure to SARS-CoV-2. | 42163369 |
No publication-dated literature was found for this virus in this window.
Summarizing recent literature with GPT-5... AI-generated summary. Interpret with care and verify against the source literature.
0 literature
0 hosts
0 countries
| Publication date | Type | Key finding | PMID |
|---|---|---|---|
| No publication-dated evidence in this window. | |||