Recent evidence findings
Synthesizing linked evidence and source literature...
Generating an evidence-grounded brief with GPT-5... AI-assisted synthesis grounded in linked OVE records and source literature. Verify details against the cited evidence.
8 source articles
6 hosts
1 countries
| Publication date | Category / type | Key finding | PMID |
|---|---|---|---|
| 2026-10-08 | Zoonotic Surveillance Virus Isolation | An H9N2 avian influenza virus was isolated from a chicken in Shandong Province, China, in March 2019. | 42849636 |
| 2026-10-08 | Zoonotic Surveillance Virus Isolation | An H9N2 avian influenza virus was isolated from a pig in Shandong Province, China, in March 2019. | 42849636 |
| 2026-10-08 | Genomic Evolution Recombination or Reassortment | Two H9N2 viruses shared an identical reassortant genome: HA/NA from Y280-like, PB2/M from G1-like, and PB1/PA/NP/NS from SH/F98-like lineages. | 42849636 |
| 2026-10-08 | Experimental Infection Pathogenicity Experiment | Two H9N2 viruses caused interstitial pneumonia and replicated in lungs and nasal turbinates of mice without significant weight loss or death and without detectable dissemination to other organs. | 42849636 |
| 2026-10-08 | Functional Mechanism Molecular Adaptation | Both H9N2 isolates carried amino acid substitutions previously linked to mammalian adaptation, receptor binding, viral replication, and antigenic variation. | 42849636 |
| 2026-10-08 | Genomic Evolution Phylogenetic Evolution | Both H9N2 isolates were classified as genotype G57 and closely related to H9N2 viruses previously detected in environmental samples in Jiangsu Province. | 42849636 |
| 2026-09-29 | Functional Mechanism Molecular Adaptation | The combined neuraminidase mutations N70S and Y155H in H9N2 increase resistance to oseltamivir and zanamivir compared to single mutants, while remaining sensitive to peramivir. | 42810520 |
| 2026-09-29 | Experimental Infection Pathogenicity Experiment | H9N2 avian influenza viruses with combined N70S and Y155H neuraminidase mutations caused high pathogenicity in BALB/c mice without prior adaptation. | 42810520 |
| 2026-09-29 | Functional Mechanism Molecular Adaptation | NAI resistance-associated neuraminidase positions in H9N2 viruses from China (1998–2024) include N70S, E119A/D/G/V, Q133K, Q136A, D151E, Y155H, I222V, R224K, E276D, R292K, N294S, and R371K. | 42810520 |
| 2026-09-29 | Experimental Infection Pathogenicity Experiment | Neuraminidase inhibitors showed limited in vivo protective effect against H9N2 virus with combined N70S/Y155H mutations, potentially due to inability to ameliorate excessive inflammatory responses. | 42810520 |
| 2026-08-21 | Genomic Evolution Recombination or Reassortment | H9N2 isolate ZHY0417A11 is a multigenic reassortant acquiring PB1 from H3N8, PA and PB2 from H3N3, NS from H10N3, and retaining an H9N2 HA/NA/NP backbone, with an M gene nearly identical to a human H3N8 isolate. | 42655736 |
| 2026-08-21 | Zoonotic Surveillance Virus Isolation | Two H9N2 avian influenza virus isolates (ZHY1022B2 and ZHY0417A11) were recovered from quail flocks in Hebei, China during 2024–2025. | 42655736 |
| 2026-08-21 | Genomic Evolution Phylogenetic Evolution | HA genes of the two H9N2 quail isolates fall within subclade B4.7.2 and segregate into subgroups B4.7.2.2 and B4.7.2.1. | 42655736 |
| 2026-08-21 | Functional Mechanism Molecular Adaptation | H9N2 isolates carry HA mammalian-adaptive markers H191N, A198V, and Q234L. | 42655736 |
| 2026-08-07 | Genomic Evolution Phylogenetic Evolution | HA phylogeny assigns the 2023 Pakistani H9N2 isolates to the G5.3.2 (formerly B2) sub-lineage within the G1 Eurasian lineage. | 42566313 |
| 2026-08-07 | Zoonotic Surveillance Virus Isolation | Five H9N2 avian influenza virus isolates were obtained from poultry in Pakistan between January and March 2023. | 42566313 |
| 2026-08-07 | Genomic Evolution Phylogenetic Evolution | All eight gene segments of the 2023 Pakistani H9N2 isolates are closely related to prior Pakistani strains with no recent reassortment, consistent with localized persistence and drift. | 42566313 |
| 2026-08-07 | Functional Mechanism Receptor Usage | G1-lineage H9N2 isolates from Pakistan bind both α2,3- and α2,6-linked sialic acid receptors, with stronger affinity for α2,6. | 42566313 |
| 2026-08-07 | Functional Mechanism Molecular Adaptation | H9N2 isolates carried several mammalian-adaptive mutations in internal genes, indicating potential cross-species transmission risk. | 42566313 |
| 2026-08 | Genomic Evolution Recombination or Reassortment | Shandong poultry H9N2 isolates are reassortants combining G1-like (PB2, M), SH/F98-like (PB1, PA, NP, NS), and Y280-like (HA, NA) lineage segments. | 42184734 |
| 2026-08 | Experimental Infection Pathogenicity Experiment | Three poultry-derived H9N2 isolates replicated efficiently in mouse lungs without causing mortality, with CK/SD/TA1016/22 showing higher replication and more severe lung lesions. | 42184734 |
| 2026-08 | Functional Mechanism Molecular Adaptation | H9N2 isolates carried human-adapted HA receptor-binding mutations and mammalian-adaptation mutations in polymerase and other genes, indicating enhanced mammalian adaptation potential. | 42184734 |
| 2026-08 | Zoonotic Surveillance Virus Isolation | Eight H9N2 avian influenza virus strains were successfully isolated from RT‑qPCR–positive chicken samples in Shandong Province, China. | 42184734 |
| 2026-08 | Zoonotic Surveillance Viral Detection | RT-qPCR detected H9N2 avian influenza virus in diseased chickens in Shandong Province during 2021–2023, with 10 positives out of 192 samples. | 42184734 |
| 2026-08 | Genomic Evolution Phylogenetic Evolution | Phylogenetic analysis of poultry-derived H9N2 isolates from Shandong showed a multi-lineage genome composition with PB2 and M from G1-like, PB1/PA/NP/NS from SH/F98-like, and HA/NA from Y280-like lineages, indicating reassortment. | 42184734 |
| 2026-07-30 | Experimental Infection Pathogenicity Experiment | H9N2 replicated effectively in lungs and nasal turbinates of BALB/c mice without prior adaptation. | 42655013 |
| 2026-07-30 | Experimental Infection Host Range Experiment | H9N2 avian influenza virus replicated and spread more efficiently in chickens than in ducks in controlled poultry infection studies. | 42655013 |
| 2026-07-30 | Experimental Infection Experimental Transmission | H9N2 avian influenza virus was transmitted to contact ducks more efficiently from infected chickens than from ducks to ducks under a controlled contact-transmission setup. | 42655013 |
| 2026-07-30 | Experimental Infection Pathogenicity Experiment | Inoculated chickens and ducks showed upregulated PRR and cytokine mRNA in lungs, with lower fold increases in ducks than chickens following H9N2 infection. | 42655013 |
| 2026-07-30 | Genomic Evolution Phylogenetic Evolution | Phylogenetic analysis placed the H9N2 isolate’s HA in the B4.7 lineage while the other seven segments were Eurasian, indicating complex reassortment across regions in China. | 42655013 |
| 2026-07-30 | Zoonotic Surveillance Virus Isolation | One H9N2 avian influenza virus was isolated from chickens in Jiangsu Province, China in March 2025. | 42655013 |
| 2026-07-30 | Functional Mechanism Molecular Adaptation | The H9N2 isolate harbors key amino acid substitutions that may enhance viral polymerase activity and replication efficiency in mice. | 42655013 |
| 2026-07-22 | Genomic Evolution Recombination or Reassortment | H3N3 isolates were reassortants with HA from the novel H3N8 AIV lineage, NA from H10N3 AIV, and internal genes from H9N2 AIV. | 42486182 |
| 2026-07-22 | Genomic Evolution Recombination or Reassortment | An H3N8 isolate was a triple-reassortant with Eurasian avian H3, North American avian N8, and H9N2-derived internal genes. | 42486182 |
| 2026-07 | Experimental Infection Host Range Experiment | H5N6 and H9N2 displayed differential lung replication and tissue tropism in human respiratory explants. | 42397692 |
Synthesizing linked evidence and source literature...
Generating an evidence-grounded brief with GPT-5... AI-assisted synthesis grounded in linked OVE records and source literature. Verify details against the cited evidence.
2 source articles
3 hosts
0 countries
| Publication date | Category / type | Key finding | PMID |
|---|---|---|---|
| 2026-10-08 | Zoonotic Surveillance Virus Isolation | An H9N2 avian influenza virus was isolated from a chicken in Shandong Province, China, in March 2019. | 42849636 |
| 2026-10-08 | Zoonotic Surveillance Virus Isolation | An H9N2 avian influenza virus was isolated from a pig in Shandong Province, China, in March 2019. | 42849636 |
| 2026-10-08 | Genomic Evolution Recombination or Reassortment | Two H9N2 viruses shared an identical reassortant genome: HA/NA from Y280-like, PB2/M from G1-like, and PB1/PA/NP/NS from SH/F98-like lineages. | 42849636 |
| 2026-10-08 | Experimental Infection Pathogenicity Experiment | Two H9N2 viruses caused interstitial pneumonia and replicated in lungs and nasal turbinates of mice without significant weight loss or death and without detectable dissemination to other organs. | 42849636 |
| 2026-10-08 | Functional Mechanism Molecular Adaptation | Both H9N2 isolates carried amino acid substitutions previously linked to mammalian adaptation, receptor binding, viral replication, and antigenic variation. | 42849636 |
| 2026-10-08 | Genomic Evolution Phylogenetic Evolution | Both H9N2 isolates were classified as genotype G57 and closely related to H9N2 viruses previously detected in environmental samples in Jiangsu Province. | 42849636 |
| 2026-09-29 | Functional Mechanism Molecular Adaptation | The combined neuraminidase mutations N70S and Y155H in H9N2 increase resistance to oseltamivir and zanamivir compared to single mutants, while remaining sensitive to peramivir. | 42810520 |
| 2026-09-29 | Experimental Infection Pathogenicity Experiment | H9N2 avian influenza viruses with combined N70S and Y155H neuraminidase mutations caused high pathogenicity in BALB/c mice without prior adaptation. | 42810520 |
| 2026-09-29 | Functional Mechanism Molecular Adaptation | NAI resistance-associated neuraminidase positions in H9N2 viruses from China (1998–2024) include N70S, E119A/D/G/V, Q133K, Q136A, D151E, Y155H, I222V, R224K, E276D, R292K, N294S, and R371K. | 42810520 |
| 2026-09-29 | Experimental Infection Pathogenicity Experiment | Neuraminidase inhibitors showed limited in vivo protective effect against H9N2 virus with combined N70S/Y155H mutations, potentially due to inability to ameliorate excessive inflammatory responses. | 42810520 |
Synthesizing linked evidence and source literature...
Generating an evidence-grounded brief with GPT-5... AI-assisted synthesis grounded in linked OVE records and source literature. Verify details against the cited evidence.
1 source articles
3 hosts
0 countries
| Publication date | Category / type | Key finding | PMID |
|---|---|---|---|
| 2026-10-08 | Zoonotic Surveillance Virus Isolation | An H9N2 avian influenza virus was isolated from a chicken in Shandong Province, China, in March 2019. | 42849636 |
| 2026-10-08 | Zoonotic Surveillance Virus Isolation | An H9N2 avian influenza virus was isolated from a pig in Shandong Province, China, in March 2019. | 42849636 |
| 2026-10-08 | Genomic Evolution Recombination or Reassortment | Two H9N2 viruses shared an identical reassortant genome: HA/NA from Y280-like, PB2/M from G1-like, and PB1/PA/NP/NS from SH/F98-like lineages. | 42849636 |
| 2026-10-08 | Experimental Infection Pathogenicity Experiment | Two H9N2 viruses caused interstitial pneumonia and replicated in lungs and nasal turbinates of mice without significant weight loss or death and without detectable dissemination to other organs. | 42849636 |
| 2026-10-08 | Functional Mechanism Molecular Adaptation | Both H9N2 isolates carried amino acid substitutions previously linked to mammalian adaptation, receptor binding, viral replication, and antigenic variation. | 42849636 |
| 2026-10-08 | Genomic Evolution Phylogenetic Evolution | Both H9N2 isolates were classified as genotype G57 and closely related to H9N2 viruses previously detected in environmental samples in Jiangsu Province. | 42849636 |