OmniVira

Characterization of a novel coronavirus associated with severe acute respiratory syndrome.

Paul A Rota1 M Steven Oberste Stephan S Monroe W Allan Nix Ray Campagnoli Joseph P Icenogle Silvia Peñaranda Bettina Bankamp Kaija Maher Min-Hsin Chen Suxiong Tong Azaibi Tamin Luis Lowe Michael Frace Joseph L DeRisi Qi Chen David Wang Dean D Erdman Teresa C T Peret Cara Burns Thomas G Ksiazek Pierre E Rollin Anthony Sanchez Stephanie Liffick Brian Holloway Josef Limor Karen McCaustland Melissa Olsen-Rasmussen Ron Fouchier Stephan Günther Albert D M E Osterhaus Christian Drosten Mark A Pallansch Larry J Anderson William J Bellini
Affiliations 1 institutions
  1. National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. [email protected]
PMID12730500 DOI10.1126/science.1085952 Year2003 Journal Science (New York, N.Y.) Science Languageeng Statusppublish

Abstract

In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.

Supporting text Virus Host Location
Genome, Viral 317 Amino Acid Sequence 128 Conserved Sequence 7 Coronavirus 92 Coronavirus M Proteins 1 Coronavirus Nucleocapsid Proteins 4 DNA, Complementary 5 Endopeptidases 2 Humans 1441 Membrane Glycoproteins 26 Molecular Sequence Data 160 Nucleocapsid Proteins 15 Open Reading Frames 25 Phylogeny 805 Polyproteins 1 Regulatory Sequences, Nucleic Acid 1 RNA, Messenger 1 RNA, Viral 193 RNA-Dependent RNA Polymerase 49 Sequence Analysis, DNA 113 Severe Acute Respiratory Syndrome 22 Severe acute respiratory syndrome-related coronavirus 78 Spike Glycoprotein, Coronavirus 274 Transcription, Genetic 5

Evidence records

2 total
Zoonotic Surveillance
1 records · 1 evidence types
Evidence type Viral Detection
1 records
OVE11440 Viral Detection
Key finding

A novel coronavirus, SARS-CoV, was detected and its genome characterized from samples associated with severe acute respiratory syndrome cases.

Virus
Severe Acute Respiratory Syndrome Coronavirus Coronaviridae
Host
human Homo sapiens Natural host
Location
Not specified
Supporting text

In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined.

Method
genome sequencing | phylogenetic analysis
Sample type
samples associated with SARS cases
Genomic Evolution
1 records · 1 evidence types
Evidence type Phylogenetic Evolution
1 records
OVE11441 Phylogenetic Evolution
Key finding

Phylogenetic analysis indicated that SARS-CoV forms a distinct lineage not closely related to previously characterized coronaviruses.

Virus
Severe Acute Respiratory Syndrome Coronavirus Coronaviridae
Host
Not specified
Location
Not specified
Supporting text

Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.

Genes or proteins
complete genome
Analysis methods
phylogenetic analysis | sequence comparison