Virus entity

Coronaviridae

ScopeICTV Family

Recent evidence findings

Evidence-grounded Research Brief · Past 3 months 63

Synthesizing linked evidence and source literature...

Generating an evidence-grounded brief with GPT-5...
24 source articles 30 hosts 7 countries
Publication date Category / type Key finding PMID
2026-07-29 Zoonotic Surveillance Viral Detection A MERS-related coronavirus (Betacoronavirus cameli) was detected by nested RT-PCR and HTS in a rectal swab from one Molossus molossus bat in southern Brazil (1/65, 1.5%). 42525174
2026-07-29 Genomic Evolution Phylogenetic Evolution Phylogenetic reconstruction of five genomic contigs placed the detected Betacoronavirus cameli within Merbecovirus and showed close relationship to MERS-CoV strains from bats and dromedary camels. 42525174
2026-07-21 Functional Mechanism Molecular Adaptation Several Guangdong pangolin coronaviruses carry a lysine substitution at spike residue 519 that confers marked immune evasion by modulating spike conformational state. 42267927
2026-07-21 Functional Mechanism Molecular Adaptation SARS-CoV-2 acquired a divergent immune-evasive mutation at spike residue 519. 42267927
2026-07-15 Experimental Infection Host Range Experiment PDCoV replicated efficiently without exogenous trypsin in human H1299 and Caco-2 cells and murine MC-38 cells, indicating high permissiveness. 42515629
2026-07-15 Experimental Infection Host Range Experiment Human H1299 and Caco-2 and murine MC-38 cells were highly susceptible to PDCoV, whereas MCF-7, TE-10, and KYSE-410 were non-permissive. 42515629
2026-07-15 Experimental Infection Pathogenicity Experiment High concentrations of trypsin triggered prominent syncytia formation in PDCoV-infected H1299, U251, and Neuro-2a cells. 42515629
2026-07-15 Experimental Infection Host Range Experiment Exogenous trypsin enhanced PDCoV replication in semi-permissive cell lines in a concentration-dependent manner. 42515629
2026-07-15 Functional Mechanism Molecular Adaptation Basal APN expression correlates with cellular susceptibility to PDCoV across tested cell lines. 42515629
2026-07-09 Genomic Evolution Phylogenetic Evolution Phylogenetic analysis of 293 SARS-CoV-2 genomes indicates repeated spillovers of human-adapted variants, including Omicron, into mink. 42425991
2026-07-09 Zoonotic Surveillance Viral Detection RT-PCR detected SARS-CoV-2 in nasal swabs from farmed mink in the United States with ~0.9% positivity (760/85,656) across 18 farms in six states during 2022-2023. 42425991
2026-07-09 Transmission Evidence Cross-species Transmission Mink-adapted SARS-CoV-2 Delta lineage AY.39 spread from a mink farm to neighboring free-ranging white-tailed deer. 42425991
2026-07-09 Transmission Evidence Outbreak Investigation Active surveillance in US farmed mink during 2022–2023 detected subclinical SARS-CoV-2 infections and interspecies transmission involving humans, mink, and wildlife. 42425991
2026-07-08 Functional Mechanism Molecular Adaptation Introducing N595K and Q596R into the FIPV-1146 RBD broadens APN receptor binding to pig, bovine, horse, and giant panda APNs. 42420488
2026-07-07 Zoonotic Surveillance Viral Detection A partial MERS-CoV genome (~20,180 bp; ~70% coverage) was detected in a Bar-headed goose in Tibet. 42372155
2026-07-07 Zoonotic Surveillance Viral Detection Universal RT-qPCR detected FCoV/CCoV RNA in 92 of 700 clinical samples from cats and dogs in Jiangsu and Zhejiang, with 79/501 cat samples and 13/199 dog samples testing positive. 42514671
2026-07-07 Functional Mechanism Receptor Usage Tundra swan and Black swan ACE2 bind SARS-CoV-2 RBDs of Alpha, Beta, and Gamma variants but not the prototype virus. 42372155
2026-07-07 Experimental Infection Host Range Experiment HeLa cells expressing Tundra swan or Black swan ACE2 were transduced by pseudotyped SARS-CoV-2 Alpha, Beta, and Gamma variants but not by prototype SARS-CoV-2. 42372155
2026-07-07 Functional Mechanism Receptor Usage HeLa cells expressing Tundra swan or Black swan ACE2 are transduced by SARS-CoV-2 Alpha, Beta, and Gamma pseudoviruses but not prototype SARS-CoV-2. 42372155
2026-07-07 Zoonotic Surveillance Viral Detection Nearly full-length SARS-CoV-2 genomes were detected in Tundra swans in Jiangxi. 42372155
2026-07-07 Genomic Evolution Phylogenetic Evolution The SARS-CoV-2 genome IMCAS_M2 from a Tundra swan possesses the Gamma VOC-characteristic RBD mutations K417T, E484K, and N501Y. 42372155
2026-07-07 Genomic Evolution Phylogenetic Evolution SARS-CoV-2 genomes IMCAS_M1 and IMCAS_M3 from Tundra swans carry the Beta VOC-characteristic RBD mutations K417N, E484K, and N501Y. 42372155
2026-07-07 Genomic Evolution Recombination or Reassortment Recombination analyses detected both intra-species and inter-species crossover events between FCoV and CCoV in companion animals from the Jiangsu–Zhejiang region in 2025. 42514671
2026-07-07 Functional Mechanism Receptor Usage Cryo-EM structures show polar contacts and hydrophobic interactions mediating engagement between swan ACE2 and SARS-CoV-2 RBD. 42372155
2026-07-03 Zoonotic Surveillance Serological Evidence In the same cat population, 3.1% were seropositive for SARS-CoV-2 antibodies confirmed by neutralization. 42427631
2026-07-03 Zoonotic Surveillance Reservoir Ecology Owned and feral cats in the Philadelphia area show minimal evidence of routine exposure to clade 2.3.4.4b H5N1 but more common exposure to SARS-CoV-2. 42427631
2026-07-02 Functional Mechanism Receptor Usage GRP78 binds the PDCoV S1 protein and promotes PDCoV attachment and internalization independent of pAPN. 42390253
2026-07-02 Functional Mechanism Receptor Usage GRP78 binds the C-terminal domain of the PDCoV S1 protein via its substrate-binding domain. 42390253
2026-07-02 Functional Mechanism Receptor Usage GRP78 facilitates PDCoV entry through clathrin-mediated endocytosis. 42390253
2026-07-02 Zoonotic Surveillance Serological Evidence Pre-existing SARS-CoV-2 immune memory showed reduced cross-neutralizing activity against the bat sarbecovirus PRD0038. 42427868
2026-07-02 Experimental Infection Host Range Experiment Porcine deltacoronavirus (PDCoV) can infect pAPN-knockout cell lines and pigs, indicating susceptibility even without pAPN. 42390253
2026-07 Experimental Infection Host Range Experiment Seasonal influenza A H1N1, H3N2, influenza B, MERS-CoV, and SARS-CoV productively replicated and infected human bronchial tissues in an ex vivo model. 42397692
2026-07-01 Zoonotic Surveillance Serological Evidence SARS-CoV-2 antibodies were detected in an Asian golden cat (Catopuma temminckii) from a German zoo cohort using sVNT and RBD-based ELISA. 42387664
2026-07-01 Zoonotic Surveillance Serological Evidence SARS-CoV-2 antibodies were detected in a European moose (Alces alces) from a German zoo cohort using sVNT and RBD-based ELISA. 42387664
2026-07 Experimental Infection Pathogenicity Experiment In an in vitro human alveolar model, HPAI H5N1, H7N9, MERS-CoV, and SARS-CoV caused more severe impairment of alveolar fluid clearance than seasonal H1N1, H3N2, and influenza B viruses. 42397692
2026-06-30 Zoonotic Surveillance Viral Detection One animal handler in Ghana tested positive for SARS-CoV-2. 42515577
2026-06-25 Zoonotic Surveillance Viral Detection Two clades of SARS-CoV-2-related coronaviruses were detected co-circulating in a horseshoe bat population in Thailand. 42097139
2026-06-25 Genomic Evolution Phylogenetic Evolution Phylogeographic analysis indicates SARS-CoV-2-related coronaviruses in Southeast Asia have a complex evolutionary history with extensive, recent geographic movement. 42097139
2026-06-25 Genomic Evolution Recombination or Reassortment SARS-CoV-2-related coronaviruses from Thailand show recombination with co-circulating virus lineages. 42097139
2026-06-25 Experimental Infection Host Range Experiment One clade of newly identified SARS-CoV-2-related coronaviruses from Thai horseshoe bats can use human ACE2 but shows reduced fusogenicity and replication in vitro compared with SARS-CoV-2. 42097139
2026-06-25 Experimental Infection Pathogenicity Experiment In hamster experiments, one newly identified SC2r-CoV clade showed lower pathogenicity than SARS-CoV-2. 42097139
2026-06-24 Experimental Infection Host Range Experiment JN.1 descendant SARS-CoV-2 variants infected cells expressing ACE2 orthologs from diverse mammalian species in a VSV pseudovirus system. 42400485
2026-06-24 Zoonotic Surveillance Serological Evidence Serum neutralization assays showed that LP.8.1.1, KP.3, XEC.25.1, XFG, and NB.1.8.1 had enhanced immune evasion compared with the JN.1 strain. 42400485
2026-06-17 Functional Mechanism Receptor Usage SARS-CoV-2 virus-like particles show a distinct preference for BSG-dependent cellular entry compared to DPP4-mediated entry. 42300082
2026-06-11 Functional Mechanism Receptor Usage Transmissible gastroenteritis virus (TGEV) uses aminopeptidase N (ANPEP) as its receptor for cellular entry in swine PK-15 cells. 42274214
2026-06 Zoonotic Surveillance Viral Detection Betacoronavirus erinacei RNA was detected by pan-CoV nested RT-PCR in fecal samples from pet long-eared hedgehogs (Hemiechinus auritus) in Italy. 42111335
2026-06 Genomic Evolution Phylogenetic Evolution Phylogenetic analysis showed that the Betacoronavirus erinacei strain detected in pet hedgehogs formed a distinct clade within European sequences, clustering with viruses from Europe and Eastern Russia rather than those from China in Amur hedgehogs. 42111335
2026-06 Zoonotic Surveillance Viral Detection SARS-CoV-2 nucleic acid was tested for and not detected in retropharyngeal lymph nodes from 110 Swedish roe deer. 41783616
2026-06 Zoonotic Surveillance Reservoir Ecology A long‑eared hedgehog‑specific strain of Betacoronavirus erinacei was identified, supporting circulation of related coronaviruses among hedgehog species across Europe and Eurasia. 42111335
2026-06 Zoonotic Surveillance Viral Detection Transmissible gastroenteritis virus was sporadically detected in slaughterhouse wastewater samples. 41695450
2026-06 Zoonotic Surveillance Viral Detection Porcine epidemic diarrhea virus was sporadically detected in slaughterhouse wastewater samples. 41695450
2026-06 Zoonotic Surveillance Viral Detection Farm air samples were valuable for detecting respiratory bovine coronavirus. 41695450
2026-06 Zoonotic Surveillance Viral Detection Bovine coronavirus was more frequently detected in slurry and wastewater samples during winter. 41695450
2026-05-26 Experimental Infection Pathogenicity Experiment MERS-CoV infection caused lethal disease in transgenic hDPP4 Syrian hamsters. 42244650
2026-05-21 Zoonotic Surveillance Virus Isolation A novel β-coronavirus strain, Murine-CoV-LH5, was successfully isolated from Rattus tanezumi captured in Dehong Prefecture, Yunnan Province. 42169115
2026-05-20 Zoonotic Surveillance Reservoir Ecology Hedgehogs were supported as ecological reservoirs maintaining circulation of coronaviruses in the Emilia-Romagna region of Italy. 42163369
2026-05-20 Zoonotic Surveillance Viral Detection Coronaviruses were molecularly detected in 90 wild mammals, mostly hedgehogs, in the Emilia-Romagna region of Italy. 42163369
2026-05-20 Zoonotic Surveillance Viral Detection Detection of Betacoronavirus erinacei sequences in non-hedgehog wild mammals indicates probable cross-species transmission among wildlife in Northern Italy. 42163369
2026-05-20 Zoonotic Surveillance Serological Evidence Anti-SARS-CoV-2 antibodies were detected in multiple wild mammal species from the Emilia-Romagna region of Italy. 42163369
2026-05-20 Zoonotic Surveillance Viral Detection EmbeCoV-related viral RNA sequences were detected in a porcupine in Emilia-Romagna, Italy. 42163369
2026-05-20 Zoonotic Surveillance Viral Detection Betacoronavirus erinacei RNA was detected in fox, porcupine, hare, and roe deer in Emilia-Romagna, Italy. 42163369
2026-05 Genomic Evolution Phylogenetic Evolution Phylogenetic analysis of coronavirus sequences from bats in Brazil showed they form divergent branches within American Alphacoronavirus lineages, with tree structuring by biome and multiple bat hosts represented in clades. 41699435
2026-05 Zoonotic Surveillance Viral Detection Coronavirus RNA was detected and sequenced from bat faecal samples collected in the Amazon‑Cerrado transition region of Mato Grosso, Brazil. 41699435
Evidence-grounded Research Brief · Past month 11

Synthesizing linked evidence and source literature...

Generating an evidence-grounded brief with GPT-5...
4 source articles 3 hosts 1 countries
Publication date Category / type Key finding PMID
2026-07-29 Zoonotic Surveillance Viral Detection A MERS-related coronavirus (Betacoronavirus cameli) was detected by nested RT-PCR and HTS in a rectal swab from one Molossus molossus bat in southern Brazil (1/65, 1.5%). 42525174
2026-07-29 Genomic Evolution Phylogenetic Evolution Phylogenetic reconstruction of five genomic contigs placed the detected Betacoronavirus cameli within Merbecovirus and showed close relationship to MERS-CoV strains from bats and dromedary camels. 42525174
2026-07-21 Functional Mechanism Molecular Adaptation Several Guangdong pangolin coronaviruses carry a lysine substitution at spike residue 519 that confers marked immune evasion by modulating spike conformational state. 42267927
2026-07-21 Functional Mechanism Molecular Adaptation SARS-CoV-2 acquired a divergent immune-evasive mutation at spike residue 519. 42267927
2026-07-15 Experimental Infection Host Range Experiment PDCoV replicated efficiently without exogenous trypsin in human H1299 and Caco-2 cells and murine MC-38 cells, indicating high permissiveness. 42515629
2026-07-15 Experimental Infection Host Range Experiment Human H1299 and Caco-2 and murine MC-38 cells were highly susceptible to PDCoV, whereas MCF-7, TE-10, and KYSE-410 were non-permissive. 42515629
2026-07-15 Experimental Infection Pathogenicity Experiment High concentrations of trypsin triggered prominent syncytia formation in PDCoV-infected H1299, U251, and Neuro-2a cells. 42515629
2026-07-15 Experimental Infection Host Range Experiment Exogenous trypsin enhanced PDCoV replication in semi-permissive cell lines in a concentration-dependent manner. 42515629
2026-07-15 Functional Mechanism Molecular Adaptation Basal APN expression correlates with cellular susceptibility to PDCoV across tested cell lines. 42515629
2026-07 Experimental Infection Host Range Experiment Seasonal influenza A H1N1, H3N2, influenza B, MERS-CoV, and SARS-CoV productively replicated and infected human bronchial tissues in an ex vivo model. 42397692
2026-07 Experimental Infection Pathogenicity Experiment In an in vitro human alveolar model, HPAI H5N1, H7N9, MERS-CoV, and SARS-CoV caused more severe impairment of alveolar fluid clearance than seasonal H1N1, H3N2, and influenza B viruses. 42397692
Evidence-grounded Research Brief · Past week 0

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Evidence-related Animal

Evidence-related animal composition

301 animal taxa

Geographic evidence

Evidence distribution by country

73 countries

Temporal evidence

Evidence dynamics by year

194 year-type groups

Publication output

Source articles by month

284 months