Recent evidence findings
Synthesizing linked evidence and source literature...
Generating an evidence-grounded brief with GPT-5... AI-assisted synthesis grounded in linked OVE records and source literature. Verify details against the cited evidence.
16 source articles
17 hosts
4 countries
| Publication date | Category / type | Key finding | PMID |
|---|---|---|---|
| 2026-10-09 | Zoonotic Surveillance Serological Evidence | A multiplex immunofluorescence assay was used to screen bat and rodent seroprevalence against 14 RNA viruses across seven families. | 42853873 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | nsp12 mutations I171V, A185S, R249K, and N611S increased replication in a SARS-CoV-2 replicon in human-cell context. | 42831623 |
| 2026-10-05 | Genomic Evolution Phylogenetic Evolution | Phylogenetic/comparative analysis of 183 bat SARS-related coronavirus nsp12 sequences identified mutation hotspots overlapping variable sites in human SARS-CoV-2 (including P323L), indicating shared functional constraints across hosts. | 42831623 |
| 2026-10-05 | Experimental Infection Host Range Experiment | Specific bat SARS-related coronavirus nsp12 mutations enhanced viral replication in both bat and human cells in controlled assays. | 42831623 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | Eight bat-derived nsp12 mutations increased polymerase activity at 37°C, with several also advantageous at 33°C or 40°C. | 42831623 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | Adaptive nsp12 mutations map to RNA capping and RdRp catalytic core regions without altering remdesivir sensitivity. | 42831623 |
| 2026-10 | Zoonotic Surveillance Serological Evidence | Sera from SARS-CoV-2 convalescent individuals robustly cross-neutralised clade 1 sarbecoviruses and showed limited cross-neutralisation across the broader sarbecovirus sub-genus. | 42821519 |
| 2026-10 | Functional Mechanism Receptor Usage | Clade 1 sarbecoviruses, including SARS-CoV-2 and the BANAL isolates from Laos, show broad ACE2 usage, whereas clade 3 (RhGB07) and clade 5 (Rc-o319) exhibit restricted ACE2 usage. | 42821519 |
| 2026-10 | Experimental Infection Host Range Experiment | Generalist sarbecoviruses maintained broad entry across a diverse mammalian ACE2 panel (human, non-human primate, livestock, rodent, and potential intermediate hosts), whereas specialists like RhGB07 showed more variable phenotypes. | 42821519 |
| 2026-10 | Zoonotic Surveillance Serological Evidence | Monoclonal antibodies derived from COVID-19 vaccinees with breakthrough infections identified epitope classes mediating broader neutralisation. | 42821519 |
| 2026-10 | Functional Mechanism Receptor Usage | SARS-CoV-2 variants, especially Omicron and its sub-lineages, display an expanding or shifting generalist pattern of ACE2 usage. | 42821519 |
| 2026-09-24 | Experimental Infection Pathogenicity Experiment | In K18-hACE2 hamsters, MpCoV-GD caused lung pathology comparable to SARS-CoV-2, with extensive damage to the alveolar parenchyma. | 42782103 |
| 2026-09-24 | Experimental Infection Host Range Experiment | Pangolin sarbecoviruses MpCoV-GX and MpCoV-GD replicate in human cells and organoids, though less efficiently than SARS-CoV-2. | 42782103 |
| 2026-09-24 | Experimental Infection Pathogenicity Experiment | In K18-hACE2 hamsters, MpCoV-GX produced milder lung disease characterized mainly by alveolar wall thickening due to mild inflammatory cell infiltration. | 42782103 |
| 2026-09-24 | Experimental Infection Experimental Transmission | MpCoV-GX transmitted via direct contact and aerosol in hACE2 transgenic hamsters, with infectivity attenuated during aerosol transmission. | 42782103 |
| 2026-09-24 | Functional Mechanism Receptor Usage | Spike proteins from pangolin sarbecoviruses mediate cell–cell membrane fusion, with MpCoV-GD fusing more strongly than MpCoV-GX but weaker than SARS-CoV-2. | 42782103 |
| 2026-09-23 | Functional Mechanism Molecular Adaptation | Host RBP NONO upregulates the MERS-CoV entry receptor DPP4 via epigenetic regulation, enabling MERS-CoV replication and entry. | 42818199 |
| 2026-09-23 | Functional Mechanism Receptor Usage | MERS-CoV uses DPP4 (CD26) as the major cellular receptor required for attachment and entry. | 42818199 |
| 2026-09-16 | Functional Mechanism Receptor Usage | Aminopeptidase N (APN) functions as a receptor for hedgehog merbecoviruses. | 42749891 |
| 2026-09-16 | Experimental Infection Host Range Experiment | Hedgehog merbecoviruses could not use human aminopeptidase N (APN) and showed restricted use across 30 mammalian APN orthologues in receptor-entry assays. | 42749891 |
| 2026-09-16 | Experimental Infection Host Range Experiment | Hedgehog coronavirus spike pseudotypes were more infectious when produced at 33 °C than at 37 °C. | 42749891 |
| 2026-09-16 | Functional Mechanism Receptor Usage | Electron cryomicroscopy defined a distinct spike–APN interface for hedgehog merbecoviruses, explaining restricted cross-species receptor usage. | 42749891 |
| 2026-09-16 | Functional Mechanism Receptor Usage | APN receptor usage by hedgehog merbecoviruses was validated using VSV-based pseudotype entry and protein binding assays. | 42749891 |
| 2026-09-08 | Zoonotic Surveillance Serological Evidence | Pre-2019 human sera from wildlife hunter communities in Guinea showed IgG cross-reactivity to SARS-CoV, SARS-CoV-2, and MERS-CoV spike antigens. | 42797820 |
| 2026-09-08 | Zoonotic Surveillance Serological Evidence | A subgroup of human sera from Guinea showed strong binding to both SARS-CoV and MERS-CoV receptor binding domains. | 42797820 |
| 2026-08-31 | Functional Mechanism Receptor Usage | The SARS-CoV-2 Delta variant spike favors multivalent engagement of ACE2 via its three RBDs. | 42671377 |
| 2026-08-31 | Functional Mechanism Molecular Adaptation | Later Omicron variants compensate a shift to predominantly single-site ACE2 engagement by increasing the stability of the RBD–ACE2 bond. | 42671377 |
| 2026-08-31 | Functional Mechanism Receptor Usage | Later Omicron variants of SARS-CoV-2 predominantly use single-site ACE2 interactions, compensated by stronger RBD–ACE2 bond stability. | 42671377 |
| 2026-08-31 | Functional Mechanism Molecular Adaptation | Spike conformational plasticity evolved from flexible early strains to rigidified Delta, fluctuating in Omicron, and compact JN.1, balancing receptor accessibility, mobility, and immune escape while maintaining entry efficiency. | 42671377 |
| 2026-08-21 | Experimental Infection Host Range Experiment | RhGB01 and BM48-31 spikes utilized only Rhinolophus blasii ACE2 in entry assays. | 42627230 |
| 2026-08-21 | Functional Mechanism Receptor Usage | ACE2 residues 31 and 41 modulate sarbecovirus spike–ACE2 interactions. | 42627230 |
| 2026-08-21 | Experimental Infection Host Range Experiment | Cloned African Rhinolophus ACE2 variants were tested in a receptor-entry system against a panel of sarbecoviruses to assess susceptibility. | 42627230 |
| 2026-08-21 | Functional Mechanism Receptor Usage | Specific ACE2 residues govern SARS-CoV-2 spike–ACE2 interactions and shape infectivity differences across species. | 42627230 |
| 2026-08-12 | Zoonotic Surveillance Viral Detection | Betacoronavirus erinacei RNA was detected in European hedgehog fecal samples in Denmark with an overall prevalence of 23% (98/430), including 16% in 2016 and 29% in 2021–22. | 42612403 |
| 2026-08-12 | Zoonotic Surveillance Reservoir Ecology | European hedgehogs were concluded to be unlikely maintenance hosts for SARS-CoV-2. | 42612403 |
| 2026-08-12 | Genomic Evolution Phylogenetic Evolution | Betacoronavirus erinacei sequence types in Danish European hedgehogs showed genetic stability across sampling years and regions based on analysis of 55 sequence types. | 42612403 |
| 2026-08-12 | Zoonotic Surveillance Reservoir Ecology | Exposure to pesticides, particularly herbicides, was positively associated with Betacoronavirus erinacei infection in European hedgehogs (p = 0.049). | 42612403 |
| 2026-08-12 | Zoonotic Surveillance Reservoir Ecology | For Betacoronavirus erinacei in European hedgehogs, prevalence showed no association with location, habitat type, age, sex, inbreeding, endoparasite infection, or MRSA presence. | 42612403 |
| 2026-08-02 | Zoonotic Surveillance Viral Detection | Porcine Hemagglutinating Encephalomyelitis Virus (PHEV) RNA was detected in 1.9% of 625 wild boar nasal swabs in Basilicata, Southern Italy using pan-coronavirus nested PCR targeting RdRp. | 42655793 |
| 2026-08-02 | Zoonotic Surveillance Reservoir Ecology | Detection of PHEV in free-ranging wild boars in Southern Italy suggests potential viral circulation at the wildlife–livestock interface with domestic pig herds. | 42655793 |
| 2026-07-29 | Zoonotic Surveillance Viral Detection | A MERS-related coronavirus (Betacoronavirus cameli) was detected by nested RT-PCR and HTS in a rectal swab from one Molossus molossus bat in southern Brazil (1/65, 1.5%). | 42525174 |
| 2026-07-29 | Zoonotic Surveillance Viral Detection | SARS-CoV-2 RNA was detected in three white-tailed deer in Massachusetts and Vermont. | 42655652 |
| 2026-07-29 | Zoonotic Surveillance Serological Evidence | ELISA detected SARS-CoV-2–reactive sera in nine wild animals across Eastern cottontail, Eastern coyote, and raccoon, indicating prior exposure. | 42655652 |
| 2026-07-29 | Genomic Evolution Phylogenetic Evolution | Phylogenetic reconstruction of five genomic contigs placed the detected Betacoronavirus cameli within Merbecovirus and showed close relationship to MERS-CoV strains from bats and dromedary camels. | 42525174 |
| 2026-07-29 | Zoonotic Surveillance Serological Evidence | Neutralizing antibodies to the SARS-CoV-2 Omicron variant were detected in a single Eastern cottontail. | 42655652 |
| 2026-07-29 | Transmission Evidence Cross-species Transmission | Phylogeographic relatedness of Vermont sequences supports a possible human-to–white-tailed deer SARS-CoV-2 spillover. | 42655652 |
| 2026-07-29 | Genomic Evolution Phylogenetic Evolution | Vermont white-tailed deer SARS-CoV-2 genomes are closely related to contemporaneous human sequences from the same region, indicating recent human–deer lineage linkage. | 42655652 |
| 2026-07-21 | Functional Mechanism Molecular Adaptation | Several Guangdong pangolin coronaviruses carry a lysine substitution at spike residue 519 that confers marked immune evasion by modulating spike conformational state. | 42267927 |
| 2026-07-21 | Functional Mechanism Molecular Adaptation | SARS-CoV-2 acquired a divergent immune-evasive mutation at spike residue 519. | 42267927 |
| 2026-07-15 | Experimental Infection Host Range Experiment | PDCoV replicated efficiently without exogenous trypsin in human H1299 and Caco-2 cells and murine MC-38 cells, indicating high permissiveness. | 42515629 |
| 2026-07-15 | Experimental Infection Host Range Experiment | Human H1299 and Caco-2 and murine MC-38 cells were highly susceptible to PDCoV, whereas MCF-7, TE-10, and KYSE-410 were non-permissive. | 42515629 |
| 2026-07-15 | Experimental Infection Pathogenicity Experiment | High concentrations of trypsin triggered prominent syncytia formation in PDCoV-infected H1299, U251, and Neuro-2a cells. | 42515629 |
| 2026-07-15 | Experimental Infection Host Range Experiment | Exogenous trypsin enhanced PDCoV replication in semi-permissive cell lines in a concentration-dependent manner. | 42515629 |
| 2026-07-15 | Functional Mechanism Molecular Adaptation | Basal APN expression correlates with cellular susceptibility to PDCoV across tested cell lines. | 42515629 |
| 2026-07 | Experimental Infection Host Range Experiment | Seasonal influenza A H1N1, H3N2, influenza B, MERS-CoV, and SARS-CoV productively replicated and infected human bronchial tissues in an ex vivo model. | 42397692 |
| 2026-07 | Experimental Infection Pathogenicity Experiment | In an in vitro human alveolar model, HPAI H5N1, H7N9, MERS-CoV, and SARS-CoV caused more severe impairment of alveolar fluid clearance than seasonal H1N1, H3N2, and influenza B viruses. | 42397692 |
Synthesizing linked evidence and source literature...
Generating an evidence-grounded brief with GPT-5... AI-assisted synthesis grounded in linked OVE records and source literature. Verify details against the cited evidence.
6 source articles
10 hosts
0 countries
| Publication date | Category / type | Key finding | PMID |
|---|---|---|---|
| 2026-10-09 | Zoonotic Surveillance Serological Evidence | A multiplex immunofluorescence assay was used to screen bat and rodent seroprevalence against 14 RNA viruses across seven families. | 42853873 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | nsp12 mutations I171V, A185S, R249K, and N611S increased replication in a SARS-CoV-2 replicon in human-cell context. | 42831623 |
| 2026-10-05 | Genomic Evolution Phylogenetic Evolution | Phylogenetic/comparative analysis of 183 bat SARS-related coronavirus nsp12 sequences identified mutation hotspots overlapping variable sites in human SARS-CoV-2 (including P323L), indicating shared functional constraints across hosts. | 42831623 |
| 2026-10-05 | Experimental Infection Host Range Experiment | Specific bat SARS-related coronavirus nsp12 mutations enhanced viral replication in both bat and human cells in controlled assays. | 42831623 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | Eight bat-derived nsp12 mutations increased polymerase activity at 37°C, with several also advantageous at 33°C or 40°C. | 42831623 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | Adaptive nsp12 mutations map to RNA capping and RdRp catalytic core regions without altering remdesivir sensitivity. | 42831623 |
| 2026-10 | Zoonotic Surveillance Serological Evidence | Sera from SARS-CoV-2 convalescent individuals robustly cross-neutralised clade 1 sarbecoviruses and showed limited cross-neutralisation across the broader sarbecovirus sub-genus. | 42821519 |
| 2026-10 | Functional Mechanism Receptor Usage | Clade 1 sarbecoviruses, including SARS-CoV-2 and the BANAL isolates from Laos, show broad ACE2 usage, whereas clade 3 (RhGB07) and clade 5 (Rc-o319) exhibit restricted ACE2 usage. | 42821519 |
| 2026-10 | Experimental Infection Host Range Experiment | Generalist sarbecoviruses maintained broad entry across a diverse mammalian ACE2 panel (human, non-human primate, livestock, rodent, and potential intermediate hosts), whereas specialists like RhGB07 showed more variable phenotypes. | 42821519 |
| 2026-10 | Zoonotic Surveillance Serological Evidence | Monoclonal antibodies derived from COVID-19 vaccinees with breakthrough infections identified epitope classes mediating broader neutralisation. | 42821519 |
| 2026-10 | Functional Mechanism Receptor Usage | SARS-CoV-2 variants, especially Omicron and its sub-lineages, display an expanding or shifting generalist pattern of ACE2 usage. | 42821519 |
| 2026-09-24 | Experimental Infection Pathogenicity Experiment | In K18-hACE2 hamsters, MpCoV-GD caused lung pathology comparable to SARS-CoV-2, with extensive damage to the alveolar parenchyma. | 42782103 |
| 2026-09-24 | Experimental Infection Host Range Experiment | Pangolin sarbecoviruses MpCoV-GX and MpCoV-GD replicate in human cells and organoids, though less efficiently than SARS-CoV-2. | 42782103 |
| 2026-09-24 | Experimental Infection Pathogenicity Experiment | In K18-hACE2 hamsters, MpCoV-GX produced milder lung disease characterized mainly by alveolar wall thickening due to mild inflammatory cell infiltration. | 42782103 |
| 2026-09-24 | Experimental Infection Experimental Transmission | MpCoV-GX transmitted via direct contact and aerosol in hACE2 transgenic hamsters, with infectivity attenuated during aerosol transmission. | 42782103 |
| 2026-09-24 | Functional Mechanism Receptor Usage | Spike proteins from pangolin sarbecoviruses mediate cell–cell membrane fusion, with MpCoV-GD fusing more strongly than MpCoV-GX but weaker than SARS-CoV-2. | 42782103 |
| 2026-09-23 | Functional Mechanism Molecular Adaptation | Host RBP NONO upregulates the MERS-CoV entry receptor DPP4 via epigenetic regulation, enabling MERS-CoV replication and entry. | 42818199 |
| 2026-09-23 | Functional Mechanism Receptor Usage | MERS-CoV uses DPP4 (CD26) as the major cellular receptor required for attachment and entry. | 42818199 |
| 2026-09-16 | Functional Mechanism Receptor Usage | Aminopeptidase N (APN) functions as a receptor for hedgehog merbecoviruses. | 42749891 |
| 2026-09-16 | Experimental Infection Host Range Experiment | Hedgehog merbecoviruses could not use human aminopeptidase N (APN) and showed restricted use across 30 mammalian APN orthologues in receptor-entry assays. | 42749891 |
| 2026-09-16 | Experimental Infection Host Range Experiment | Hedgehog coronavirus spike pseudotypes were more infectious when produced at 33 °C than at 37 °C. | 42749891 |
| 2026-09-16 | Functional Mechanism Receptor Usage | Electron cryomicroscopy defined a distinct spike–APN interface for hedgehog merbecoviruses, explaining restricted cross-species receptor usage. | 42749891 |
| 2026-09-16 | Functional Mechanism Receptor Usage | APN receptor usage by hedgehog merbecoviruses was validated using VSV-based pseudotype entry and protein binding assays. | 42749891 |
Synthesizing linked evidence and source literature...
Generating an evidence-grounded brief with GPT-5... AI-assisted synthesis grounded in linked OVE records and source literature. Verify details against the cited evidence.
2 source articles
5 hosts
0 countries
| Publication date | Category / type | Key finding | PMID |
|---|---|---|---|
| 2026-10-09 | Zoonotic Surveillance Serological Evidence | A multiplex immunofluorescence assay was used to screen bat and rodent seroprevalence against 14 RNA viruses across seven families. | 42853873 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | nsp12 mutations I171V, A185S, R249K, and N611S increased replication in a SARS-CoV-2 replicon in human-cell context. | 42831623 |
| 2026-10-05 | Genomic Evolution Phylogenetic Evolution | Phylogenetic/comparative analysis of 183 bat SARS-related coronavirus nsp12 sequences identified mutation hotspots overlapping variable sites in human SARS-CoV-2 (including P323L), indicating shared functional constraints across hosts. | 42831623 |
| 2026-10-05 | Experimental Infection Host Range Experiment | Specific bat SARS-related coronavirus nsp12 mutations enhanced viral replication in both bat and human cells in controlled assays. | 42831623 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | Eight bat-derived nsp12 mutations increased polymerase activity at 37°C, with several also advantageous at 33°C or 40°C. | 42831623 |
| 2026-10-05 | Functional Mechanism Molecular Adaptation | Adaptive nsp12 mutations map to RNA capping and RdRp catalytic core regions without altering remdesivir sensitivity. | 42831623 |