Host entity

human

Homo sapiens

Rankspecies NCBI Taxon: 9606

Recent evidence findings

Evidence-grounded Research Brief · Past 3 months 21

Synthesizing linked evidence and source literature...

Generating an evidence-grounded brief with GPT-5...
16 source articles 16 viruses 3 countries
Publication date Category / type Key finding PMID
2026-10-10 Genomic Evolution Phylogenetic Evolution A nearly full-length rat RHEV genome from Northwestern Italy is highly related to previously reported rodent and human RHEV sequences, including European cases. 42856010
2026-10-10 Zoonotic Surveillance Reservoir Ecology Detection of RHEV-positive rodents on livestock farms indicates circulation at a rural wildlife–livestock–human interface. 42856010
2026-10-05 Genomic Evolution Phylogenetic Evolution Phylogenetic/comparative analysis of 183 bat SARS-related coronavirus nsp12 sequences identified mutation hotspots overlapping variable sites in human SARS-CoV-2 (including P323L), indicating shared functional constraints across hosts. 42831623
2026-10 Experimental Infection Host Range Experiment Generalist sarbecoviruses maintained broad entry across a diverse mammalian ACE2 panel (human, non-human primate, livestock, rodent, and potential intermediate hosts), whereas specialists like RhGB07 showed more variable phenotypes. 42821519
2026-10 Functional Mechanism Receptor Usage SARS-CoV-2 variants, especially Omicron and its sub-lineages, display an expanding or shifting generalist pattern of ACE2 usage. 42821519
2026-09-29 Genomic Evolution Phylogenetic Evolution Phylogenetic analysis indicates that HA A227E and NA S369N substitutions were acquired in swine prior to the emergence of H1N1pdm09 in humans. 42776754
2026-09-24 Experimental Infection Host Range Experiment Pangolin sarbecoviruses MpCoV-GX and MpCoV-GD replicate in human cells and organoids, though less efficiently than SARS-CoV-2. 42782103
2026-09-08 Zoonotic Surveillance Serological Evidence Pre-2019 human sera from wildlife hunter communities in Guinea showed IgG cross-reactivity to SARS-CoV, SARS-CoV-2, and MERS-CoV spike antigens. 42797820
2026-09-08 Zoonotic Surveillance Serological Evidence A subgroup of human sera from Guinea showed strong binding to both SARS-CoV and MERS-CoV receptor binding domains. 42797820
2026-09 Genomic Evolution Phylogenetic Evolution A detected protoparvovirus from UK diarrhoeic dogs clustered within the same species as human-canine-associated parvovirus 1. 42709036
2026-08 Functional Mechanism Receptor Usage Most mammalian nectin-4 orthologs efficiently support infection by representative morbilliviruses in cell-based assays. 42593857
2026-08 Genomic Evolution Phylogenetic Evolution Recent sequence analysis shows high variation at PA/PA-X site 94 in H5N1 and H7N9, with the PA-X I94V mutation becoming prevalent in recent human H7N9 viruses. 42090884
2026-07-29 Transmission Evidence Cross-species Transmission Phylogeographic relatedness of Vermont sequences supports a possible human-to–white-tailed deer SARS-CoV-2 spillover. 42655652
2026-07-29 Genomic Evolution Phylogenetic Evolution Vermont white-tailed deer SARS-CoV-2 genomes are closely related to contemporaneous human sequences from the same region, indicating recent human–deer lineage linkage. 42655652
2026-07-26 Functional Mechanism Receptor Usage Emerging H5N1 clade 2.3.4.4b binds human MHC-II HLA-DR and can mediate sialic acid–independent cell entry, unlike historical H5 lineages. 42539232
2026-07-26 Transmission Evidence Outbreak Investigation HPAI H5N1 clade 2.3.4.4b is reported as causing a multi-species outbreak affecting wild birds, poultry, multiple mammalian species, and humans. 42539232
2026-07-23 Genomic Evolution Phylogenetic Evolution Phylogenetic analysis showed G8 RVA strains clustering within multi-host-associated lineages that include bovine-like human and caprine strains, while G6 strains clustered within more host-restricted bovine lineages. 42492859
2026-07-17 Functional Mechanism Receptor Usage Ailong virus uses human ephrin B2 (EFNB2) and ephrin B3 (EFNB3) as functional receptors. 42467734
2026-07-17 Experimental Infection Pathogenicity Experiment In human bronchial epithelial Calu-3 cells, H5N1 clade 2.3.4.4b viruses induced moderate type I interferon and proinflammatory responses, lower than A(H1N1)pdm09 and H5N1 clade 1. 42466872
2026-07 Zoonotic Surveillance Viral Detection Tracheal aspirate sequencing from a 2024 human HPAI H5N1 case in British Columbia detected mixed HA-190D (28%) and HA-226H (35%) variant populations. 42498495
2026-07 Experimental Infection Host Range Experiment H5N6 and H9N2 displayed differential lung replication and tissue tropism in human respiratory explants. 42397692
Evidence-grounded Research Brief · Past month 8

Synthesizing linked evidence and source literature...

Generating an evidence-grounded brief with GPT-5...
6 source articles 7 viruses 1 countries
Publication date Category / type Key finding PMID
2026-10-10 Genomic Evolution Phylogenetic Evolution A nearly full-length rat RHEV genome from Northwestern Italy is highly related to previously reported rodent and human RHEV sequences, including European cases. 42856010
2026-10-10 Zoonotic Surveillance Reservoir Ecology Detection of RHEV-positive rodents on livestock farms indicates circulation at a rural wildlife–livestock–human interface. 42856010
2026-10-05 Genomic Evolution Phylogenetic Evolution Phylogenetic/comparative analysis of 183 bat SARS-related coronavirus nsp12 sequences identified mutation hotspots overlapping variable sites in human SARS-CoV-2 (including P323L), indicating shared functional constraints across hosts. 42831623
2026-10 Experimental Infection Host Range Experiment Generalist sarbecoviruses maintained broad entry across a diverse mammalian ACE2 panel (human, non-human primate, livestock, rodent, and potential intermediate hosts), whereas specialists like RhGB07 showed more variable phenotypes. 42821519
2026-10 Functional Mechanism Receptor Usage SARS-CoV-2 variants, especially Omicron and its sub-lineages, display an expanding or shifting generalist pattern of ACE2 usage. 42821519
2026-09-29 Genomic Evolution Phylogenetic Evolution Phylogenetic analysis indicates that HA A227E and NA S369N substitutions were acquired in swine prior to the emergence of H1N1pdm09 in humans. 42776754
2026-09-24 Experimental Infection Host Range Experiment Pangolin sarbecoviruses MpCoV-GX and MpCoV-GD replicate in human cells and organoids, though less efficiently than SARS-CoV-2. 42782103
2026-09 Genomic Evolution Phylogenetic Evolution A detected protoparvovirus from UK diarrhoeic dogs clustered within the same species as human-canine-associated parvovirus 1. 42709036
Evidence-grounded Research Brief · Past week 3

Synthesizing linked evidence and source literature...

Generating an evidence-grounded brief with GPT-5...
2 source articles 2 viruses 1 countries
Publication date Category / type Key finding PMID
2026-10-10 Genomic Evolution Phylogenetic Evolution A nearly full-length rat RHEV genome from Northwestern Italy is highly related to previously reported rodent and human RHEV sequences, including European cases. 42856010
2026-10-10 Zoonotic Surveillance Reservoir Ecology Detection of RHEV-positive rodents on livestock farms indicates circulation at a rural wildlife–livestock–human interface. 42856010
2026-10-05 Genomic Evolution Phylogenetic Evolution Phylogenetic/comparative analysis of 183 bat SARS-related coronavirus nsp12 sequences identified mutation hotspots overlapping variable sites in human SARS-CoV-2 (including P323L), indicating shared functional constraints across hosts. 42831623

Linked viruses

Virus composition linked to this host

215 virus taxa

Geographic evidence

Evidence distribution by country

85 countries

Temporal evidence

Evidence dynamics by year

247 year-type groups

Publication output

Source articles by month

702 months