OmniVira

Severe fever with thrombocytopenia syndrome virus among domesticated animals, China.

Guoyu Niu1 Jiandong Li Mifang Liang Xiaolin Jiang Mei Jiang Haiying Yin Zhidian Wang Chuan Li Quanfu Zhang Cong Jin Xianjun Wang Shujun Ding Zheng Xing Shiwen Wang Zhenqiang Bi Dexin Li
Affiliations 1 institutions
  1. Key Laboratory for Medical Virology–Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China.
PMID23648209 DOI10.3201/eid1905.120245 Year2013 Journal Emerging infectious diseases Emerg Infect Dis Languageeng Statusppublish

Abstract

To investigate the infections of severe fever with thrombocytopenia syndrome virus (SFTSV) in domesticated animals, we sampled a total of 3,039 animals in 2 counties in Shandong Province, People's Republic of China, from April to November 2011. SFTSV-specific antibodies were detected in 328 (69.5%) of 472 sheep, 509 (60.5%) of 842 cattle, 136 (37.9%) of 359 dogs, 26 (3.1%) of 839 pigs, and 250 (47.4%) of 527 chickens. SFTSV RNA was detected in all sampled animal species, but the prevalence was low, ranging from 1.7% to 5.3%. A cohort study in 38 sheep was conducted to determine when seroconversion to SFTSV occured. SFTSVs were isolated from sheep, cattle, and dogs and shared >95% sequence homology with human isolates from the same disease-endemic regions. These findings demonstrate that natural infections of SFTSV occur in several domesticated animal hosts in disease-endemic areas and that the virus has a wide host range.

Supporting text Virus Host Location
China 230 domesticated animals 2 family Bunyaviridae 1 host 7 infection 12 pathogenic disease 1 Phlebovirus 6 prevalence 72 severe fever with thrombocytopenia syndrome virus 1 SFTSV 4 transmission 55 viruses 117 zoonoses 477 Animals 1948 Antibodies, Viral 212 Bunyaviridae Infections 9 Cattle 126 Chickens 146 China 229 Dogs 176 Humans 1440 Phlebovirus 5 Phylogeny 805 Prevalence 62

Evidence records

10 total
Zoonotic Surveillance
10 records · 4 evidence types
Evidence type Virus Isolation
3 records
Evidence type Viral Detection
1 records
OVE1429 Viral Detection
Key finding

SFTSV RNA was detected in sheep, cattle, dogs, pigs, and chickens in Shandong Province, People's Republic of China, at low prevalence (1.7%–5.3%).

Virus
severe fever with thrombocytopenia syndrome virus
Host
sheep Ovis aries Natural host domestic cattle Bos taurus Natural host dog Canis lupus familiaris Natural host pig Sus scrofa Natural host chicken Gallus gallus Natural host
Location
China
Supporting text

To investigate the infections of severe fever with thrombocytopenia syndrome virus (SFTSV) in domesticated animals, we sampled a total of 3,039 animals in 2 counties in Shandong Province, People's Republic of China, from April to November 2011. SFTSV RNA was detected in all sampled animal species, but the prevalence was low, ranging from 1.7% to 5.3%.

Method
RNA detection | reverse transcription PCR (RT-PCR)
Geographic raw
Shandong Province | People's Republic of China
Country inferred
CHN
Evidence type Serological Evidence
5 records
Evidence type Reservoir Ecology
1 records
OVE1433 Reservoir Ecology
Key finding

Natural infections of severe fever with thrombocytopenia syndrome virus (SFTSV) occur in multiple domesticated animal species in endemic areas of Shandong Province, indicating broad host range and potential maintenance of the virus within these populations.

Virus
severe fever with thrombocytopenia syndrome virus
Host
sheep Ovis aries Natural host domestic cattle Bos taurus Natural host dog Canis lupus familiaris Natural host pig Sus scrofa Natural host chicken Gallus gallus Natural host
Location
China
Supporting text

These findings demonstrate that natural infections of SFTSV occur in several domesticated animal hosts in disease-endemic areas and that the virus has a wide host range.

Method
serological testing for SFTSV antibodies | PCR detection of SFTSV RNA | virus isolation from animal samples
Sample type
serum | blood samples
Geographic raw
Shandong Province | People's Republic of China | disease-endemic areas
Country inferred
CHN