OmniVira

Literature detail

Severe fever with thrombocytopenia syndrome virus among domesticated animals, China.

Guoyu Niu1 Jiandong Li Mifang Liang Xiaolin Jiang Mei Jiang Haiying Yin Zhidian Wang Chuan Li Quanfu Zhang Cong Jin Xianjun Wang Shujun Ding Zheng Xing Shiwen Wang Zhenqiang Bi Dexin Li
Affiliations 1 institutions
  1. Key Laboratory for Medical Virology–Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China.
PMID 23648209 2013 Emerg Infect Dis eng ppublish
PubMed DOI Browse context

Article

Publication summary

To investigate the infections of severe fever with thrombocytopenia syndrome virus (SFTSV) in domesticated animals, we sampled a total of 3,039 animals in 2 counties in Shandong Province, People's Republic of China, from April to November 2011. SFTSV-specific antibodies were detected in 328 (69.5%) of 472 sheep, 509 (60.5%) of 842 cattle, 136 (37.9%) of 359 dogs, 26 (3.1%) of 839 pigs, and 250 (47.4%) of 527 chickens. SFTSV RNA was detected in all sampled animal species, but the prevalence was low, ranging from 1.7% to 5.3%. A cohort study in 38 sheep was conducted to determine when seroconversion to SFTSV occured. SFTSVs were isolated from sheep, cattle, and dogs and shared >95% sequence homology with human isolates from the same disease-endemic regions. These findings demonstrate that natural infections of SFTSV occur in several domesticated animal hosts in disease-endemic areas and that the virus has a wide host range.

China domesticated animals family Bunyaviridae host infection pathogenic disease Phlebovirus prevalence severe fever with thrombocytopenia syndrome virus SFTSV transmission viruses zoonoses Animals Antibodies, Viral Bunyaviridae Infections Cattle Chickens

Structured evidence records

Evidence records

10 total
Zoonotic Surveillance 5 records
Zoonotic Surveillance Extraction confidence 0.98
Key finding

Serological and molecular surveillance detected SFTSV infection and isolated virus from domesticated animals including sheep, cattle, and dogs in Shandong Province, China.

Virus
SFTSV
Host
Ovis aries
Location
China Shandong Province, China
Supporting text

SFTSV-specific antibodies were detected in 328 (69.5%) of 472 sheep... SFTSV RNA was detected in all sampled animal species... SFTSVs were isolated from sheep, cattle, and dogs in Shandong Province, People's Republic of China.

Method
serology; RNA detection; virus isolation
Sample type
blood
Geographic raw
Shandong Province
Country inferred
China
Zoonotic Surveillance Extraction confidence 0.98
Key finding

Serological and molecular evidence confirmed SFTSV infection and isolation from cattle in Shandong Province, China.

Virus
SFTSV
Host
Bos taurus
Location
China Shandong Province, China
Supporting text

SFTSV-specific antibodies were detected in 509 (60.5%) of 842 cattle... SFTSV RNA was detected in all sampled animal species... SFTSVs were isolated from sheep, cattle, and dogs.

Method
serology; RNA detection; virus isolation
Sample type
blood
Geographic raw
Shandong Province
Country inferred
China
Zoonotic Surveillance Extraction confidence 0.98
Key finding

Serological and molecular surveillance detected SFTSV infection and virus isolation from dogs in Shandong Province, China.

Virus
SFTSV
Location
China Shandong Province, China
Supporting text

SFTSV-specific antibodies were detected in 136 (37.9%) of 359 dogs... SFTSV RNA was detected in all sampled animal species... SFTSVs were isolated from sheep, cattle, and dogs.

Method
serology; RNA detection; virus isolation
Sample type
blood
Geographic raw
Shandong Province
Country inferred
China
Zoonotic Surveillance Extraction confidence 0.95
Key finding

SFTSV antibodies and RNA were detected at low prevalence in pigs in Shandong Province, China.

Virus
SFTSV
Host
Sus scrofa
Location
China Shandong Province, China
Supporting text

SFTSV-specific antibodies were detected in 26 (3.1%) of 839 pigs... SFTSV RNA was detected in all sampled animal species.

Method
serology; RNA detection
Sample type
blood
Geographic raw
Shandong Province
Country inferred
China
Zoonotic Surveillance Extraction confidence 0.95
Key finding

SFTSV antibodies and RNA were detected in chickens in Shandong Province, China, indicating exposure to the virus.

Virus
SFTSV
Location
China Shandong Province, China
Supporting text

SFTSV-specific antibodies were detected in 250 (47.4%) of 527 chickens... SFTSV RNA was detected in all sampled animal species.

Method
serology; RNA detection
Sample type
blood
Geographic raw
Shandong Province
Country inferred
China
Genomic Evolution 3 records
Genomic Evolution Extraction confidence 0.75
Key finding

Severe fever with thrombocytopenia syndrome virus isolates from sheep, cattle, and dogs showed high nucleotide sequence similarity with human-derived isolates, indicating close evolutionary relatedness between animal and human strains.

Virus
SFTSV
Host
Ovis aries
Location
Not specified
Supporting text

SFTSVs were isolated from sheep, cattle, and dogs and shared >95% sequence homology with human isolates from the same disease-endemic regions.

Genes or proteins
whole genome
Analysis methods
sequence homology analysis
Genomic Evolution Extraction confidence 0.75
Key finding

Severe fever with thrombocytopenia syndrome virus isolates from cattle exhibited over 95% sequence homology with human isolates, supporting genomic evidence of interspecies evolutionary proximity.

Virus
SFTSV
Host
Bos taurus
Location
Not specified
Supporting text

SFTSVs were isolated from sheep, cattle, and dogs and shared >95% sequence homology with human isolates from the same disease-endemic regions.

Genes or proteins
whole genome
Analysis methods
sequence homology analysis
Genomic Evolution Extraction confidence 0.75
Key finding

Severe fever with thrombocytopenia syndrome virus isolates from dogs shared more than 95% nucleotide sequence similarity with human isolates, revealing strong genomic relatedness between animal and human strains.

Virus
SFTSV
Location
Not specified
Supporting text

SFTSVs were isolated from sheep, cattle, and dogs and shared >95% sequence homology with human isolates from the same disease-endemic regions.

Genes or proteins
whole genome
Analysis methods
sequence homology analysis
Cross Species Transmission 1 records
Cross Species Transmission Extraction confidence 0.85
Key finding

SFTSV infected multiple domesticated animal species including sheep, cattle, dogs, pigs, and chickens in China, consistent with cross-species transmission among non-human hosts.

Virus
SFTSV
Location
China China
Supporting text

SFTSV-specific antibodies were detected in sheep, cattle, dogs, pigs, and chickens. SFTSV RNA was detected in all sampled animal species, and viruses were isolated from sheep, cattle, and dogs. These findings demonstrate that natural infections of SFTSV occur in several domesticated animal hosts and that the virus has a wide host range.

Method
serological testing; RNA detection; virus isolation; sequence analysis
Study design
field surveillance
Transmission direction
animal-to-animal
Geographic raw
Shandong Province, People's Republic of China
Country inferred
China
Serological Evidence 1 records
Serological Evidence Extraction confidence 0.97
Key finding

SFTSV-specific antibodies and seroconversion were detected in multiple domesticated animal species in China, showing exposure to the virus.

Virus
SFTSV
Location
Not specified
Supporting text

SFTSV-specific antibodies were detected in 328 (69.5%) of 472 sheep, 509 (60.5%) of 842 cattle, 136 (37.9%) of 359 dogs, 26 (3.1%) of 839 pigs, and 250 (47.4%) of 527 chickens. A cohort study in 38 sheep was conducted to determine when seroconversion to SFTSV occurred.

Method
antibody detection; seroconversion study
Sample type
serum