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Literature detail

Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013.

Ziad A Memish Matthew Cotten Benjamin Meyer Simon J Watson Abdullah J Alsahafi Abdullah A Al Rabeeah Victor Max Corman Andrea Sieberg Hatem Q Makhdoom Abdullah Assiri Malaki Al Masri Souhaib Aldabbagh Berend-Jan Bosch Martin Beer Marcel A Müller Paul Kellam Christian Drosten
PMID 24857749 2014 Emerg Infect Dis eng ppublish
PubMed DOI Browse context

Article

Publication summary

We investigated a case of human infection with Middle East respiratory syndrome coronavirus (MERS-CoV) after exposure to infected camels. Analysis of the whole human-derived virus and 15% of the camel-derived virus sequence yielded nucleotide polymorphism signatures suggestive of cross-species transmission. Camels may act as a direct source of human MERS-CoV infection.

coronavirus dromedary camels MERS Middle East respiratory syndrome respiratory infections Saudi Arabia viruses Adult Animals Camelus Coronavirus Infections High-Throughput Nucleotide Sequencing Humans Male Middle East Respiratory Syndrome Coronavirus

Structured evidence records

Evidence records

2 total
Genomic Evolution 1 records
Genomic Evolution Extraction confidence 0.90
Key finding

Whole-genome and partial camel MERS-CoV sequences showed nucleotide polymorphisms suggesting camel-to-human cross-species transmission.

Virus
MERS-CoV
Location
Not specified
Supporting text

Analysis of the whole human-derived virus and 15% of the camel-derived virus sequence yielded nucleotide polymorphism signatures suggestive of cross-species transmission.

Genes or proteins
whole genome
Analysis methods
sequence analysis
Spillover Event 1 records
Spillover Event Extraction confidence 0.98
Key finding

Human MERS-CoV infection occurred after exposure to infected camels, indicating camel-to-human spillover in Saudi Arabia.

Virus
MERS-CoV
Location
Saudi Arabia Saudi Arabia
Supporting text

We investigated a case of human infection with Middle East respiratory syndrome coronavirus (MERS-CoV) after exposure to infected camels. Analysis of the whole human-derived virus and 15% of the camel-derived virus sequence yielded nucleotide polymorphism signatures suggestive of cross-species transmission.

Method
whole-genome sequencing
Study design
case report
Transmission direction
animal-to-human
Geographic raw
Saudi Arabia
Country inferred
Saudi Arabia