OmniVira

Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013.

Ziad A Memish Matthew Cotten Benjamin Meyer Simon J Watson Abdullah J Alsahafi Abdullah A Al Rabeeah Victor Max Corman Andrea Sieberg Hatem Q Makhdoom Abdullah Assiri Malaki Al Masri Souhaib Aldabbagh Berend-Jan Bosch Martin Beer Marcel A Müller Paul Kellam Christian Drosten
PMID24857749 DOI10.3201/eid2006.140402 Year2014 Journal Emerging infectious diseases Emerg Infect Dis Languageeng Statusppublish

Abstract

We investigated a case of human infection with Middle East respiratory syndrome coronavirus (MERS-CoV) after exposure to infected camels. Analysis of the whole human-derived virus and 15% of the camel-derived virus sequence yielded nucleotide polymorphism signatures suggestive of cross-species transmission. Camels may act as a direct source of human MERS-CoV infection.

Supporting text Virus Host Location
coronavirus 195 dromedary camels 6 MERS 4 Middle East respiratory syndrome 6 respiratory infections 30 Saudi Arabia 15 viruses 117 Adult 71 Animals 1948 Camelus 39 Coronavirus Infections 171 High-Throughput Nucleotide Sequencing 39 Humans 1440 Male 224 Middle East Respiratory Syndrome Coronavirus 68

Evidence records

2 total
Zoonotic Surveillance
1 records · 1 evidence types
Evidence type Reservoir Ecology
1 records
OVE1713 Reservoir Ecology
Key finding

Camels may serve as a direct source or ecological reservoir for MERS-CoV infection in humans in Saudi Arabia.

Virus
Middle East Respiratory Syndrome Coronavirus
Host
Camelus Natural host
Location
Saudi Arabia
Supporting text

Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013.

Method
virus genomic sequence analysis | comparative nucleotide polymorphism analysis
Sample type
camel-derived virus sequence
Geographic raw
Saudi Arabia
Country inferred
SAU
Transmission Evidence
1 records · 1 evidence types
Evidence type Spillover Event
1 records
OVE1711 Spillover Event
Key finding

A human infection with Middle East respiratory syndrome coronavirus (MERS-CoV) occurred after exposure to infected camels in Saudi Arabia, indicating camel-to-human spillover.

Virus
Middle East Respiratory Syndrome Coronavirus
Host
human Homo sapiens Natural host Camelus Natural host
Location
Saudi Arabia
Supporting text

Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013. We investigated a case of human infection with Middle East respiratory syndrome coronavirus (MERS-CoV) after exposure to infected camels.

Method
viral genome sequencing | exposure investigation
Study design
case investigation of human infection after animal exposure
Transmission direction
animal-to-human
Geographic raw
Saudi Arabia
Country inferred
SAU