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Literature detail

Hervey virus: Study on co-circulation with Henipaviruses in Pteropid bats within their distribution range from Australia to Africa.

Claudia Kohl1 Mary Tachedjian2 Shawn Todd2 Paul Monaghan2 Victoria Boyd2 Glenn A Marsh2 Gary Crameri2 Hume Field3,4 Andreas Kurth1 Ina Smith2 Lin-Fa Wang2,5
Affiliations 5 institutions
  1. Robert Koch Institute, Centre for Biological Threats and Special Pathogens, Seestraße 10, Berlin, Germany.
  2. CSIRO Health and Biosecurity, Australian Animal Health Laboratory, Geelong, Victoria, Australia.
  3. Queensland Centre for Emerging Infectious Diseases, Department of Agriculture and Fisheries, Brisbane, Queensland, Australia.
  4. EcoHealth Alliance, New York, United States of America.
  5. Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
PMID 29390028 2018 PLoS One eng epublish
PubMed DOI Browse context

Article

Publication summary

In 2011, an unusually large number of independent Hendra virus outbreaks were recorded on horse properties in Queensland and New South Wales, Australia. Urine from bat colonies adjacent to the outbreak sites were sampled and screened for Hendra and other viruses. Several novel paramyxoviruses were also isolated at different locations. Here one of the novel viruses, named Hervey virus (HerPV), is fully characterized by genome sequencing, annotation, phylogeny and in vitro host range, and its serological cross-reactivity and neutralization patterns are examined. HerPV may have ecological and spatial and temporal patterns similar to Hendra virus and could serve as a sentinel virus for the surveillance of this highly pathogenic virus. The suitability of HerPV as potential sentinel virus is further assessed by determining the serological prevalence of HerPV antibodies in fruit-eating bats from Australia, Indonesia, Papua New Guinea, Tanzania and the Gulf of Guinea, indicating the presence of similar viruses in regions beyond the Australian border.

Africa Animals Antibodies, Viral Australia Cell Line Chiroptera Disease Outbreaks Henipavirus Henipavirus Infections High-Throughput Nucleotide Sequencing Indonesia Microscopy, Confocal Neutralization Tests Papua New Guinea Paramyxovirinae

Structured evidence records

Evidence records

10 total
Zoonotic Surveillance 5 records
Zoonotic Surveillance Extraction confidence 0.95
Key finding

Surveillance sampling and serological screening in Pteropid bats detected Hervey virus and antibodies across regions from Australia to Africa, supporting monitoring for henipaviruses and related paramyxoviruses.

Virus
HerV
Location
Australia Australia
Supporting text

Urine from bat colonies adjacent to the outbreak sites were sampled and screened for Hendra and other viruses. ... The suitability of HerPV as potential sentinel virus is further assessed by determining the serological prevalence of HerPV antibodies in fruit-eating bats from Australia, Indonesia, Papua New Guinea, Tanzania and the Gulf of Guinea.

Method
serology; genome sequencing
Sample type
urine; serum
Geographic raw
Australia
Country inferred
Australia
Zoonotic Surveillance Extraction confidence 0.95
Key finding

Serological survey of fruit bats from Indonesia detected antibodies to Hervey virus, suggesting circulation of related viruses outside Australia.

Virus
HerV
Host
Chiroptera
Location
Indonesia Indonesia
Supporting text

The serological prevalence of HerPV antibodies in fruit-eating bats from Australia, Indonesia, Papua New Guinea, Tanzania and the Gulf of Guinea, indicating the presence of similar viruses in regions beyond the Australian border.

Method
serology
Sample type
serum
Geographic raw
Indonesia
Country inferred
Indonesia
Zoonotic Surveillance Extraction confidence 0.95
Key finding

Fruit bats in Papua New Guinea showed serological evidence of exposure to Hervey virus.

Virus
HerV
Host
Chiroptera
Location
Papua New Guinea Papua New Guinea
Supporting text

Serological prevalence of HerPV antibodies in fruit-eating bats from Papua New Guinea.

Method
serology
Sample type
serum
Geographic raw
Papua New Guinea
Country inferred
Papua New Guinea
Zoonotic Surveillance Extraction confidence 0.95
Key finding

Fruit bats sampled in Tanzania showed serological evidence of Hervey virus or related paramyxoviruses.

Virus
HerV
Host
Chiroptera
Location
Tanzania Tanzania
Supporting text

Serological prevalence of HerPV antibodies in fruit-eating bats from Tanzania and the Gulf of Guinea.

Method
serology
Sample type
serum
Geographic raw
Tanzania
Country inferred
Tanzania
Zoonotic Surveillance Extraction confidence 0.90
Key finding

Fruit bats from the Gulf of Guinea displayed serological reactivity to Hervey virus, suggesting wider geographic distribution.

Virus
HerV
Host
Chiroptera
Location
Gulf of Guinea
Supporting text

Serological prevalence of HerPV antibodies in fruit-eating bats from the Gulf of Guinea, indicating the presence of similar viruses in regions beyond the Australian border.

Method
serology
Sample type
serum
Geographic raw
Gulf of Guinea
Reservoir Ecology 2 records
Reservoir Ecology Extraction confidence 0.80
Key finding

Hervey virus antibodies were detected in fruit-eating bats across multiple countries, indicating a wide ecological distribution and potential reservoir role in these bat populations.

Virus
HerV
Host
Chiroptera
Location
Australia Australia
Supporting text

The suitability of HerPV as potential sentinel virus is further assessed by determining the serological prevalence of HerPV antibodies in fruit-eating bats from Australia, Indonesia, Papua New Guinea, Tanzania and the Gulf of Guinea, indicating the presence of similar viruses in regions beyond the Australian border.

Method
serology; field sampling
Sample type
urine; bat sera
Geographic raw
Australia
Country inferred
Australia
Reservoir Ecology Extraction confidence 0.80
Key finding

Detection of Hervey virus antibodies in bats from multiple regions suggests bats serve as widespread reservoirs across Asia and Africa.

Virus
HerV
Host
Chiroptera
Location
Tanzania Tanzania
Supporting text

Hervey virus antibodies were found in fruit-eating bats from Indonesia, Papua New Guinea, Tanzania and the Gulf of Guinea, indicating the presence of similar viruses in regions beyond the Australian border.

Method
serological testing
Sample type
bat sera
Geographic raw
Tanzania
Country inferred
Tanzania
Genomic Evolution 1 records
Genomic Evolution Extraction confidence 0.90
Key finding

Hervey virus was fully characterized through genome sequencing and phylogenetic analysis, revealing its evolutionary relationship with Henipaviruses.

Virus
HerV
Location
Not specified
Supporting text

Here one of the novel viruses, named Hervey virus (HerPV), is fully characterized by genome sequencing, annotation, phylogeny and in vitro host range.

Genes or proteins
whole genome
Analysis methods
genome sequencing; phylogenetic analysis
Host Range Experiment 1 records
Host Range Experiment Extraction confidence 0.85
Key finding

Hervey virus was experimentally tested for its in vitro host range and neutralization characteristics to evaluate potential host susceptibility and antigenic relationships.

Virus
HerV
Location
Not specified
Supporting text

Hervey virus (HerPV) is fully characterized by genome sequencing, annotation, phylogeny and in vitro host range, and its serological cross-reactivity and neutralization patterns are examined.

Method
in vitro host range assay; neutralization test
Experimental system
in vitro cell culture
Serological Evidence 1 records
Serological Evidence Extraction confidence 0.90
Key finding

Hervey virus antibodies were serologically detected in fruit-eating bats across multiple countries, indicating widespread viral exposure.

Virus
HerV
Host
Chiroptera
Location
Not specified
Supporting text

The suitability of HerPV as potential sentinel virus is further assessed by determining the serological prevalence of HerPV antibodies in fruit-eating bats from Australia, Indonesia, Papua New Guinea, Tanzania and the Gulf of Guinea, indicating the presence of similar viruses in regions beyond the Australian border.

Method
serological prevalence; neutralization tests
Sample type
serum