OmniVira

A potential role for integrins in host cell entry by SARS-CoV-2.

Christian Ja Sigrist1 Alan Bridge2 Philippe Le Mercier3
Affiliations 3 institutions
  1. Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, Switzerland. Electronic address: [email protected].
  2. Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, Switzerland. Electronic address: [email protected].
  3. Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, Switzerland. Electronic address: [email protected].
PMID32130973 DOI10.1016/j.antiviral.2020.104759 Year2020 Journal Antiviral research Antiviral Res Languageeng Publication statusActive
Active Last checked 2026-10-06 03:30:27 Source: NCBI PubMed

Abstract

• Integrin may act as an alternative receptor for SARS-CoV-2 and could be implicated in its transmission and pathology. • The spike protein of SARS-CoV-2 acquired a RGD motif known to bind integrins. This motif is absent from other coronaviruses. • The integrin-binding motif is present at the surface of the spike protein, close to the ACE2 receptor-binding region. • Integrin binding may be a promising therapeutics target, and should be tested experimentally.

Virus Internalization 100 Animals 1981 Betacoronavirus 79 Coronavirus Infections 172 COVID-19 427 Drug Delivery Systems 0 Host-Pathogen Interactions 55 Humans 1455 Integrins 1 Pandemics 109 Pneumonia, Viral 42 Protein Binding 194 Protein Interaction Domains and Motifs 12 SARS-CoV-2 456 Spike Glycoprotein, Coronavirus 276 spike protein, SARS-CoV-2 158

Evidence records

0 total

No structured evidence records are linked to this article.