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Literature detail

A potential role for integrins in host cell entry by SARS-CoV-2.

Christian Ja Sigrist1 Alan Bridge2 Philippe Le Mercier3
Affiliations 3 institutions
  1. Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, Switzerland. Electronic address: [email protected].
  2. Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, Switzerland. Electronic address: [email protected].
  3. Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, Switzerland. Electronic address: [email protected].
PMID 32130973 2020 Antiviral Res eng ppublish
PubMed DOI Browse context

Article

Publication summary

• Integrin may act as an alternative receptor for SARS-CoV-2 and could be implicated in its transmission and pathology. • The spike protein of SARS-CoV-2 acquired a RGD motif known to bind integrins. This motif is absent from other coronaviruses. • The integrin-binding motif is present at the surface of the spike protein, close to the ACE2 receptor-binding region. • Integrin binding may be a promising therapeutics target, and should be tested experimentally.

Virus Internalization Animals Betacoronavirus Coronavirus Infections COVID-19 Drug Delivery Systems Host-Pathogen Interactions Humans Integrins Pandemics Pneumonia, Viral Protein Binding Protein Interaction Domains and Motifs SARS-CoV-2 Spike Glycoprotein, Coronavirus spike protein, SARS-CoV-2

Structured evidence records

Evidence records

2 total
Molecular Adaptation 1 records
Molecular Adaptation Extraction confidence 0.90
Key finding

SARS-CoV-2 spike protein gained an RGD motif absent in other coronaviruses, enabling potential integrin binding that may affect host entry and adaptation.

Virus
SARS-CoV-2
Host
Not specified
Location
Not specified
Supporting text

The spike protein of SARS-CoV-2 acquired a RGD motif known to bind integrins. This motif is absent from other coronaviruses.

Genes or proteins
spike protein
Receptors
integrin; ACE2
Mutations
RGD motif
Mechanism types
receptor_binding; cell_entry; host_factor_interaction
Receptor Usage 1 records
Receptor Usage Extraction confidence 0.95
Key finding

Integrins are proposed as alternative receptors for SARS-CoV-2 via an RGD motif in the spike protein positioned near the ACE2 binding region.

Virus
SARS-CoV-2
Host
host cell
Location
Not specified
Supporting text

Integrin may act as an alternative receptor for SARS-CoV-2 and could be implicated in its transmission and pathology. The spike protein of SARS-CoV-2 acquired a RGD motif known to bind integrins.

Receptors
integrins
Host factors
ACE2