OmniVira

Origin and cross-species transmission of bat coronaviruses in China.

Alice Latinne1,2,3 Ben Hu4 Kevin J Olival1 Guangjian Zhu1 Libiao Zhang5 Hongying Li1 Aleksei A Chmura1 Hume E Field1,6 Carlos Zambrana-Torrelio1 Jonathan H Epstein1 Bei Li4 Wei Zhang4 Lin-Fa Wang7 Zheng-Li Shi8 Peter Daszak9
Affiliations 9 institutions
  1. EcoHealth Alliance, New York, USA.
  2. Wildlife Conservation Society, Viet Nam Country Program, Ha Noi, Viet Nam
  3. Wildlife Conservation Society, Health Program, Bronx, NY, USA.
  4. Key Laboratory of Special Pathogens And Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
  5. Guangdong Institute of Applied Biological Resources, Guangdong Academy of Sciences, Guangzhou, China.
  6. School of Veterinary Science, The University of Queensland, Brisbane, QLD, Australia.
  7. Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
  8. Key Laboratory of Special Pathogens And Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. [email protected].
  9. EcoHealth Alliance, New York, USA. [email protected].
PMID32843626 DOI10.1038/s41467-020-17687-3 Year2020 Journal Nature communications Nat Commun Languageeng Publication statusRetracted
Retracted Last checked 2026-10-05 03:30:31 Source: NCBI PubMed Retraction Note: Origin and cross-species transmission of bat coronaviruses in China. (2024-12-19)

Abstract

Bats are presumed reservoirs of diverse coronaviruses (CoVs) including progenitors of Severe Acute Respiratory Syndrome (SARS)-CoV and SARS-CoV-2, the causative agent of COVID-19. However, the evolution and diversification of these coronaviruses remains poorly understood. Here we use a Bayesian statistical framework and a large sequence data set from bat-CoVs (including 630 novel CoV sequences) in China to study their macroevolution, cross-species transmission and dispersal. We find that host-switching occurs more frequently and across more distantly related host taxa in alpha- than beta-CoVs, and is more highly constrained by phylogenetic distance for beta-CoVs. We show that inter-family and -genus switching is most common in Rhinolophidae and the genus Rhinolophus. Our analyses identify the host taxa and geographic regions that define hotspots of CoV evolutionary diversity in China that could help target bat-CoV discovery for proactive zoonotic disease surveillance. Finally, we present a phylogenetic analysis suggesting a likely origin for SARS-CoV-2 in Rhinolophus spp. bats.

Evolution, Molecular 178 Animals 1981 Bayes Theorem 33 Betacoronavirus 79 Biodiversity 10 China 234 Chiroptera 376 Coronavirus 93 Coronavirus Infections 172 COVID-19 427 Humans 1455 Pandemics 109 Phylogeny 826 Phylogeography 32 Pneumonia, Viral 42 SARS-CoV-2 456 Zoonoses 401

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