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Literature detail

Susceptibility and Attenuated Transmissibility of SARS-CoV-2 in Domestic Cats.

Linlin Bao1,2 Zhiqi Song1,2 Jing Xue1,2 Hong Gao1,2 Jiangning Liu1,2 Jie Wang1,2 Qian Guo2 Binbin Zhao1,2 Yajin Qu1,2 Feifei Qi1,2 Shuran Gong1,2 Mingya Liu1,2 Qi Lv1,2 Dan Li1,2 Yunlin Han1,2 Wenjie Zhao1,2 Shoulong Deng2 Yunpeng Liu2 Zhiguang Xiang2 Bochao Yang2 Wei Deng1,2 Haisheng Yu1,2 Zhe Cong1,2 Qiang Wei1,2 Jianguo Xu3 George F Gao4 Chuan Qin1,2
Affiliations 4 institutions
  1. Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.
  2. NHC Key Laboratory of Human Disease Comparative Medicine, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.
  3. National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
  4. Chinese Center for Disease Control and Prevention, Beijing, China.
PMID 33605423 2021 J Infect Dis eng ppublish
PubMed DOI Browse context

Article

Publication summary

Domestic cats, an important companion animal, can be infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This has aroused concern regarding the ability of domestic cats to spread the virus that causes coronavirus disease 2019. We systematically demonstrated the pathogenesis and transmissibility of SARS-CoV-2 in cats. Serial passaging of the virus between cats dramatically attenuated the viral transmissibility, likely owing to variations of the amino acids in the receptor-binding domain sites of angiotensin-converting enzyme 2 between humans and cats. These findings provide insight into the transmissibility of SARS-CoV-2 in cats and information for protecting the health of humans and cats.

cats COVID-19 pathogenesis SARS-CoV-2 susceptibility transmissibility Amino Acids Angiotensin-Converting Enzyme 2 Animals Cats Cell Line Chlorocebus aethiops COVID-19 Female Humans Male SARS-CoV-2 Vero Cells

Structured evidence records

Evidence records

3 total
Host Range Experiment 1 records
Host Range Experiment Extraction confidence 0.95
Key finding

Experimental infection and serial passage showed domestic cats are susceptible to SARS-CoV-2 and transmissibility was reduced after repeated cat-to-cat transmission.

Virus
SARS-CoV-2
Location
Not specified
Supporting text

We systematically demonstrated the pathogenesis and transmissibility of SARS-CoV-2 in cats. Serial passaging of the virus between cats dramatically attenuated the viral transmissibility.

Method
experimental infection; serial passaging
Experimental system
in vivo animal experiment
Molecular Adaptation 1 records
Molecular Adaptation Extraction confidence 0.85
Key finding

Amino acid differences in the receptor-binding domain affecting ACE2 interactions between humans and cats contribute to attenuation of SARS-CoV-2 transmissibility in domestic cats.

Virus
SARS-CoV-2
Host
Not specified
Location
Not specified
Supporting text

Serial passaging of the virus between cats dramatically attenuated the viral transmissibility, likely owing to variations of the amino acids in the receptor-binding domain sites of angiotensin-converting enzyme 2 between humans and cats.

Genes or proteins
receptor-binding domain; ACE2
Receptors
ACE2
Mechanism types
receptor_binding; transmission_fitness
Receptor Usage 1 records
Receptor Usage Extraction confidence 0.80
Key finding

Differences in amino acids in the receptor-binding domain of SARS-CoV-2 correspond to variations in ACE2 between humans and cats, influencing viral transmissibility.

Virus
SARS-CoV-2
Location
Not specified
Supporting text

Serial passaging of the virus between cats dramatically attenuated the viral transmissibility, likely owing to variations of the amino acids in the receptor-binding domain sites of angiotensin-converting enzyme 2 between humans and cats.

Receptors
angiotensin-converting enzyme 2