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Literature detail

SARS-CoV-2 infection and transmission in the North American deer mouse.

Bryan D Griffin1 Mable Chan1 Nikesh Tailor1 Emelissa J Mendoza1 Anders Leung1 Bryce M Warner1,2 Ana T Duggan3 Estella Moffat4 Shihua He1 Lauren Garnett1,2 Kaylie N Tran1 Logan Banadyga1 Alixandra Albietz1 Kevin Tierney1 Jonathan Audet1 Alexander Bello1 Robert Vendramelli1 Amrit S Boese1 Lisa Fernando1 L Robbin Lindsay1,5 Claire M Jardine6 Heidi Wood1 Guillaume Poliquin2,7,8 James E Strong1,2,7 Michael Drebot1,2 David Safronetz1,2 Carissa Embury-Hyatt4 Darwyn Kobasa9,10
Affiliations 10 institutions
  1. Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
  2. Department of Medical Microbiology and Infectious Diseases, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
  3. Science Technology Cores and Services, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
  4. National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB, Canada.
  5. Department of Entomology, University of Manitoba, Winnipeg, MB, Canada.
  6. Department of Pathobiology, Canadian Wildlife Health Cooperative, Department of Pathobiology, University of Guelph, Guelph, ON, Canada.
  7. Pediatrics & Child Health, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
  8. Office of the Scientific Director, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, MB, Canada.
  9. Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada. [email protected].
  10. Department of Medical Microbiology and Infectious Diseases, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. [email protected].
PMID 34127676 2021 Nat Commun eng epublish
PubMed DOI Browse context

Article

Publication summary

Widespread circulation of SARS-CoV-2 in humans raises the theoretical risk of reverse zoonosis events with wildlife, reintroductions of SARS-CoV-2 into permissive nondomesticated animals. Here we report that North American deer mice (Peromyscus maniculatus) are susceptible to SARS-CoV-2 infection following intranasal exposure to a human isolate, resulting in viral replication in the upper and lower respiratory tract with little or no signs of disease. Further, shed infectious virus is detectable in nasal washes, oropharyngeal and rectal swabs, and viral RNA is detectable in feces and occasionally urine. We further show that deer mice are capable of transmitting SARS-CoV-2 to naïve deer mice through direct contact. The extent to which these observations may translate to wild deer mouse populations remains unclear, and the risk of reverse zoonosis and/or the potential for the establishment of Peromyscus rodents as a North American reservoir for SARS-CoV-2 remains unknown.

Animals Animals, Wild Antibodies, Neutralizing COVID-19 Disease Susceptibility Feces Female Histiocytes Humans Male Neutrophils Peromyscus RNA, Viral SARS-CoV-2 United States Zoonoses

Structured evidence records

Evidence records

3 total
Host Range Experiment 2 records
Host Range Experiment Extraction confidence 0.98
Key finding

Experimental intranasal infection revealed that deer mice support replication of a human SARS-CoV-2 isolate in respiratory tissues.

Virus
SARS-CoV-2
Location
Not specified
Supporting text

North American deer mice (Peromyscus maniculatus) are susceptible to SARS-CoV-2 infection following intranasal exposure to a human isolate, resulting in viral replication in the upper and lower respiratory tract with little or no signs of disease.

Method
experimental infection; intranasal exposure; replication assay
Sample type
upper respiratory tract; lower respiratory tract
Experimental system
in vivo animal experiment
Host Range Experiment Extraction confidence 0.96
Key finding

Deer mice experimentally infected with SARS-CoV-2 transmitted the virus to naïve deer mice via direct contact.

Virus
SARS-CoV-2
Location
Not specified
Supporting text

We further show that deer mice are capable of transmitting SARS-CoV-2 to naïve deer mice through direct contact.

Method
transmission experiment; direct contact exposure
Experimental system
in vivo animal experiment
Cross Species Transmission 1 records
Cross Species Transmission Extraction confidence 0.95
Key finding

SARS-CoV-2 was transmitted from infected North American deer mice to naïve deer mice by direct contact.

Virus
SARS-CoV-2
Location
United States North America
Supporting text

We further show that deer mice are capable of transmitting SARS-CoV-2 to naïve deer mice through direct contact.

Method
experimental infection
Study design
animal experiment
Transmission direction
animal-to-animal
Geographic raw
North America
Country inferred
United States