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Literature detail

N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding.

Zubiao Niu1,2 Zhengrong Zhang1,2 Xiaoyan Gao3 Peng Du1,2 Jingjing Lu1,2 Bohua Yan1,2 Chenxi Wang1,2 You Zheng1,2 Hongyan Huang4 Qiang Sun1,5
Affiliations 5 institutions
  1. Laboratory of Cell Engineering, Institute of Biotechnology
  2. Research Unit of Cell Death Mechanism, Chinese Academy of Medical Sciences, 2020RU009, Beijing, China.
  3. Department of Oncology, Beijing Shijitan Hospital of Capital Medical University, Beijing, China.
  4. Department of Oncology, Beijing Shijitan Hospital of Capital Medical University, Beijing, China. [email protected].
  5. Research Unit of Cell Death Mechanism, Chinese Academy of Medical Sciences, 2020RU009, Beijing, China. [email protected].
PMID 34315847 2021 Signal Transduct Target Ther eng epublish
PubMed DOI Browse context

Article

Publication summary

No abstract text is available for this record.

COVID-19 SARS-CoV-2 Animals Humans Mice Mutation Protein Binding Spike Glycoprotein, Coronavirus

Structured evidence records

Evidence records

3 total
Cross Species Transmission 1 records
Cross Species Transmission Extraction confidence 0.90
Key finding

The N501Y mutation in SARS-CoV-2 enables transmission of the virus to mice by enhancing receptor binding.

Virus
SARS-CoV-2
Location
Not specified
Supporting text

N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding.

Transmission direction
animal-to-animal
Molecular Adaptation 1 records
Molecular Adaptation Extraction confidence 0.95
Key finding

The N501Y mutation in the SARS-CoV-2 spike protein enhances receptor binding and allows transmission from humans to mice.

Virus
SARS-CoV-2
Host
Not specified
Location
Not specified
Supporting text

N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding.

Genes or proteins
Spike Glycoprotein
Mutations
N501Y
Mechanism types
receptor_binding; cross_species_transmission
Receptor Usage 1 records
Receptor Usage Extraction confidence 0.90
Key finding

The N501Y substitution in SARS-CoV-2 spike increases affinity for the mouse receptor, enabling mouse infection.

Virus
SARS-CoV-2
Location
Not specified
Supporting text

N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding.

Receptors
receptor (likely ACE2, though only 'receptor' is explicitly stated)