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Literature detail

SARS-CoV-2 Seroconversion in an Adult Horse with Direct Contact to a COVID-19 Individual.

Nicola Pusterla1 Antoine Chaillon2 Caroline Ignacio2 Davey M Smith2 Samantha Barnum1 Kaila O Y Lawton1 Greg Smith3 Bradley Pickering3
Affiliations 3 institutions
  1. Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
  2. Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, CA 92093, USA.
  3. National Center for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB R3E 3M4, Canada.
PMID 35632788 2022 Viruses eng epublish
PubMed DOI Browse context

Article

Publication summary

The authors report on a possible direct exposure to SARS-CoV-2 from a COVID-19-positive individual to an adult horse. The individual, diagnosed with COVID-19 (Delta B.1.617.2), had daily contact to her two horses prior to and during the development of clinical disease. None of the two horses developed abnormal clinical signs or had detectable SARS-CoV-2 in blood, nasal secretion, or feces via RT-qPCR. However, one of the two horses showed close temporal seroconversion to SARS-CoV-2 using a protein-based ELISA and the plaque reduction neutralization test. The results suggest that horses can become silently infected with SARS-CoV-2 following close contact with humans infected with SARS-CoV-2. As a precautionary measure, humans infected with SARS-CoV-2 should avoid close contact with equids and other companion animals during the time of their illness to prevent viral transmission.

antibodies COVID-19 horse SARS-CoV-2 spillover COVID-19 SARS-CoV-2 Animals Enzyme-Linked Immunosorbent Assay Female Horses Seroconversion SARS-CoV-2 variants

Structured evidence records

Evidence records

2 total
Serological Evidence 1 records
Serological Evidence Extraction confidence 0.95
Key finding

An adult horse in contact with a COVID-19-positive human seroconverted to SARS-CoV-2 by ELISA and neutralization testing, indicating exposure and likely silent infection.

Virus
SARS-CoV-2
Location
Not specified
Supporting text

One of the two horses showed close temporal seroconversion to SARS-CoV-2 using a protein-based ELISA and the plaque reduction neutralization test.

Method
ELISA; plaque reduction neutralization test
Sample type
serum
Spillover Event 1 records
Spillover Event Extraction confidence 0.92
Key finding

An adult horse developed SARS-CoV-2 antibodies after close contact with a COVID-19-positive human, suggesting human-to-horse transmission.

Virus
SARS-CoV-2
Location
Not specified
Supporting text

The authors report on a possible direct exposure to SARS-CoV-2 from a COVID-19-positive individual to an adult horse... one of the two horses showed close temporal seroconversion to SARS-CoV-2.

Method
RT-qPCR; protein-based ELISA; plaque reduction neutralization test
Study design
case report
Transmission direction
human-to-animal