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Genomic characterization of a novel G3P[10] rotavirus strain from a diarrheic child in Thailand: Evidence for bat-to-human zoonotic transmission.

Satoshi Komoto1 Ratana Tacharoenmuang2,3 Ratigorn Guntapong3 Sompong Upachai3 Phakapun Singchai3 Tomihiko Ide4 Saori Fukuda4 Riona Hatazawa4 Karun Sutthiwarakom3 Santip Kongjorn3 Napa Onvimala3 Tipsuda Luechakham3 Busarawan Sriwanthana5 Takayuki Murata4 Ballang Uppapong3 Koki Taniguchi4
Affiliations 5 institutions
  1. Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan. Electronic address: [email protected].
  2. Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan
  3. National Institute of Health, Department of Medical Sciences, Nonthaburi 11000, Thailand.
  4. Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
  5. Medical Sciences Technical Office, Department of Medical Sciences, Nonthaburi 11000, Thailand.
PMID33285275 DOI10.1016/j.meegid.2020.104667 Year2021 Journal Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases Infect Genet Evol Languageeng Publication statusActive
Active Last checked 2026-10-05 03:30:31 Source: NCBI PubMed

Abstract

An unusual rotavirus strain with the G3P[10] genotype (RVA/Human-wt/THA/MS2015-1-0001/2015/G3P[10]) was identified in a stool sample from a hospitalized child aged 11 months with severe gastroenteritis in Thailand. In the current study, we sequenced and characterized the full genome of strain MS2015-1-0001. On full-genomic analysis, strain MS2015-1-0001 exhibited the following genotype configuration: G3-P[10]-I8-R3-C3-M3-A9-N3-T3-E3-H6, which is identical or closely related to those of bat and bat-like rotavirus strains (MYAS33-like). Furthermore, phylogenetic analysis revealed that all 11 genes of strain MS2015-1-0001 appeared to be of bat origin. Our findings provide evidence for bat-to-human interspecies transmission of rotaviruses and important insights into dynamic interactions between human and bat rotavirus strains.

Supporting text Virus Host Location
Bat origin 2 G3P[10] strains 1 Group A rotavirus 8 Interspecies transmission 55 Thailand 26 Whole genomic analysis 2 Viral Zoonoses 66 Animals 1981 Chiroptera 376 Feces 117 Gastroenteritis 14 Genome, Viral 324 Humans 1455 Infant 26 Male 225 Rotavirus 66 Rotavirus Infections 62 Thailand 22

Evidence records

3 total
Zoonotic Surveillance
1 records · 1 evidence types
Evidence type Viral Detection
1 records
OVE4336 Viral Detection
Key finding

A novel G3P[10] rotavirus strain (RVA/Human-wt/THA/MS2015-1-0001/2015/G3P[10]) was detected in a stool sample from a hospitalized child with gastroenteritis in Thailand.

Virus
Rotavirus A
Host
human Homo sapiens Natural host
Location
Thailand
Supporting text

An unusual rotavirus strain with the G3P[10] genotype (RVA/Human-wt/THA/MS2015-1-0001/2015/G3P[10]) was identified in a stool sample from a hospitalized child aged 11 months with severe gastroenteritis in Thailand.

Method
genomic sequencing | genotype identification
Sample type
stool sample
Geographic raw
Thailand
Country inferred
THA
Genomic Evolution
2 records · 1 evidence types
Evidence type Phylogenetic Evolution
2 records
OVE4337 Phylogenetic Evolution
Key finding

Full-genome phylogenetic analysis showed that rotavirus strain MS2015-1-0001 was closely related to bat rotavirus lineages, with all 11 genome segments appearing to be derived from bat viruses.

Virus
Rotavirus Rotavirus A
Host
bats Chiroptera Context pending
Location
Not specified
Supporting text

Phylogenetic analysis revealed that all 11 genes of strain MS2015-1-0001 appeared to be of bat origin, and the full genotype configuration was identical or closely related to bat and bat-like rotavirus strains (MYAS33-like).

Genes or proteins
full genome | 11 genes
Analysis methods
full-genomic analysis | phylogenetic analysis
OVE4338 Phylogenetic Evolution
Key finding

Genomic evidence indicates bat-to-human spillover of rotaviruses in Thailand.

Virus
Rotavirus
Host
bats Chiroptera Natural host human Homo sapiens Natural host
Location
Thailand
Supporting text

Our findings provide evidence for bat-to-human interspecies transmission of rotaviruses and important insights into dynamic interactions between human and bat rotavirus strains.

Analysis methods
full-genome sequencing | phylogenetic analysis