Literature detail

Experimental infection and natural contact exposure of dogs with avian influenza virus (H5N1).

Matthias Giese1 Timm C Harder Jens P Teifke Robert Klopfleisch Angele Breithaupt Thomas C Mettenleiter Thomas W Vahlenkamp
Affiliations 1 institutions
  1. Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.
PMID 18258127 2008 Emerg Infect Dis eng ppublish
PubMed DOI Browse context

Article

Publication summary

Experiments that exposed influenza virus (H5N1)-infected cats to susceptible dogs did not result in intraspecies or interspecies transmission. Infected dogs showed increased body temperatures, viral RNA in pharyngeal swabs, and seroconversion but not fatal disease.

Animals Cat Diseases Cats Disease Transmission, Infectious Dog Diseases Dogs Influenza A Virus, H5N1 Subtype Orthomyxoviridae Infections Pharynx RNA, Viral

Structured evidence records

Evidence records

3 total
1 records
Extraction confidence 0.75
Key finding

H5N1-infected cats did not transmit virus to dogs despite close experimental contact.

Virus
Location
Not specified
Supporting text

Experiments that exposed influenza virus (H5N1)-infected cats to susceptible dogs did not result in intraspecies or interspecies transmission.

Method
experimental infection; contact exposure
Study design
animal experiment
Transmission direction
animal-to-animal
1 records
Extraction confidence 0.95
Key finding

Experimental infection showed that dogs can be infected with avian influenza virus (H5N1), exhibit mild symptoms with viral RNA detection and seroconversion, but the virus was not transmitted to other dogs or cats.

Virus
Location
Not specified
Supporting text

Experiments that exposed influenza virus (H5N1)-infected cats to susceptible dogs did not result in intraspecies or interspecies transmission. Infected dogs showed increased body temperatures, viral RNA in pharyngeal swabs, and seroconversion but not fatal disease.

Method
experimental infection; contact exposure
Sample type
pharyngeal swabs
Experimental system
in vivo animal experiment
1 records
Extraction confidence 0.90
Key finding

Experimentally infected dogs developed antibodies to avian influenza virus (H5N1), demonstrating seroconversion after infection.

Virus
Location
Not specified
Supporting text

Infected dogs showed increased body temperatures, viral RNA in pharyngeal swabs, and seroconversion but not fatal disease.

Sample type
serum