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Literature detail

Porcine Deltacoronavirus Infection and Transmission in Poultry, United States<sup>1</sup>.

Patricia A Boley Moyasar A Alhamo Geoffrey Lossie Kush Kumar Yadav Marcia Vasquez-Lee Linda J Saif Scott P Kenney
PMID 31961296 2020 Emerg Infect Dis eng ppublish
PubMed DOI Browse context

Article

Publication summary

Coronaviruses cause respiratory and gastrointestinal diseases in diverse host species. Deltacoronaviruses (DCoVs) have been identified in various songbird species and in leopard cats in China. In 2009, porcine deltacoronavirus (PDCoV) was detected in fecal samples from pigs in Asia, but its etiologic role was not identified until 2014, when it caused major diarrhea outbreaks in swine in the United States. Studies have shown that PDCoV uses a conserved region of the aminopeptidase N protein to infect cell lines derived from multiple species, including humans, pigs, and chickens. Because PDCoV is a potential zoonotic pathogen, investigations of its prevalence in humans and its contribution to human disease continue. We report experimental PDCoV infection and subsequent transmission among poultry. In PDCoV-inoculated chicks and turkey poults, we observed diarrhea, persistent viral RNA titers from cloacal and tracheal samples, PDCoV-specific serum IgY antibody responses, and antigen-positive cells from intestines.

chickens coronaviruses interspecies transmission Porcine deltacoronavirus poultry swine disease turkeys United States viruses zoonoes Animals Chickens Coronavirus Infections Deltacoronavirus Swine Swine Diseases Turkeys United States

Structured evidence records

Evidence records

5 total
Host Range Experiment 2 records
Host Range Experiment Extraction confidence 0.95
Key finding

Porcine deltacoronavirus experimentally infected chicks and turkey poults, causing diarrhea, viral replication, and transmission among poultry.

Virus
PDCoV
Location
Not specified
Supporting text

We report experimental PDCoV infection and subsequent transmission among poultry. In PDCoV-inoculated chicks and turkey poults, we observed diarrhea, persistent viral RNA titers from cloacal and tracheal samples, PDCoV-specific serum IgY antibody responses, and antigen-positive cells from intestines.

Method
experimental infection
Sample type
cloacal samples; tracheal samples; intestines
Experimental system
in vivo animal experiment
Host Range Experiment Extraction confidence 0.95
Key finding

Porcine deltacoronavirus experimentally infected turkey poults, causing diarrhea, viral replication, and transmission among poultry.

Virus
PDCoV
Location
Not specified
Supporting text

We report experimental PDCoV infection and subsequent transmission among poultry. In PDCoV-inoculated chicks and turkey poults, we observed diarrhea, persistent viral RNA titers from cloacal and tracheal samples, PDCoV-specific serum IgY antibody responses, and antigen-positive cells from intestines.

Method
experimental infection
Sample type
cloacal samples; tracheal samples; intestines
Experimental system
in vivo animal experiment
Serological Evidence 2 records
Serological Evidence Extraction confidence 0.90
Key finding

Chicks and turkey poults experimentally inoculated with porcine deltacoronavirus developed PDCoV-specific serum IgY antibodies, indicating serological evidence of infection.

Virus
PDCoV
Location
Not specified
Supporting text

In PDCoV-inoculated chicks and turkey poults, we observed diarrhea, persistent viral RNA titers from cloacal and tracheal samples, PDCoV-specific serum IgY antibody responses, and antigen-positive cells from intestines.

Sample type
serum
Serological Evidence Extraction confidence 0.90
Key finding

Turkey poults experimentally inoculated with porcine deltacoronavirus developed PDCoV-specific serum IgY antibodies, showing serological evidence of infection.

Virus
PDCoV
Location
Not specified
Supporting text

In PDCoV-inoculated chicks and turkey poults, we observed diarrhea, persistent viral RNA titers from cloacal and tracheal samples, PDCoV-specific serum IgY antibody responses, and antigen-positive cells from intestines.

Sample type
serum
Cross Species Transmission 1 records
Cross Species Transmission Extraction confidence 0.95
Key finding

Porcine deltacoronavirus was experimentally transmitted among poultry, showing infection and spread between chickens and turkeys.

Virus
PDCoV
Location
United States United States
Supporting text

We report experimental PDCoV infection and subsequent transmission among poultry. In PDCoV-inoculated chicks and turkey poults, we observed diarrhea, persistent viral RNA titers from cloacal and tracheal samples, PDCoV-specific serum IgY antibody responses, and antigen-positive cells from intestines.

Method
experimental infection; serology; viral RNA detection
Study design
animal experiment
Transmission direction
animal-to-animal
Geographic raw
United States
Country inferred
United States