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Literature detail

Evidence of neutralizing antibodies against SARS-CoV-2 in domestic cats living with owners with a history of COVID-19 in Lima - Peru.

Luis M Jara1 Cusi Ferradas2 Francesca Schiaffino1 Camila Sánchez-Carrión3 Ana Martínez-Vela4 Alexandra Ulloa3 Gisela Isasi-Rivas5 Angela Montalván5 Luis Guevara Sarmiento5 Manolo Fernández5 Mirko Zimic5,6
Affiliations 6 institutions
  1. Facultad de Medicina Veterinaria y Zootecnia, Universidad Peruana Cayetano Heredia, Lima, Peru.
  2. Unidad de Investigación en Enfermedades Emergentes y Cambio Climático (Emerge), Facultad de Salud Pública y Administración, Universidad Peruana Cayetano Heredia, Lima, Peru.
  3. Clínica Veterinaria Gatuario, Lima, Peru.
  4. Clínica Veterinaria Los Dominicos, Lima, Peru.
  5. Farmacológicos Veterinarios (FARVET), Chincha, Peru.
  6. Laboratorio de Bioinformática, Biología Molecular y Desarrollos Tecnológicos, Universidad Peruana Cayetano Heredia, Lima, Peru.
PMID 34462726 2021 One Health eng ppublish
PubMed DOI Browse context

Article

Publication summary

SARS-CoV-2 can infect a variety of wild and domestic animals worldwide. Of these, domestic cats are highly susceptible species and potential viral reservoirs. As such, it is important to investigate disease exposure in domestic cats in areas with active community transmission and high disease prevalence. In this report we demonstrate the presence of serum neutralizing antibodies against the receptor binding-domain (RBD) of the SARS-CoV-2 in cats whose owners had been infected with SARS-CoV-2 in Lima, Peru, using a commercial competitive ELISA SARS-CoV-2 Surrogate Virus Neutralization Test. Out of 41 samples, 17.1% (7/41) and 31.7% (13/41) were positive, using the cut-off inhibition value of 30% and 20%, respectively. Not all cats living in a single house had detectable neutralizing antibodies showing heterogenous exposure and immunity among cohabiting animals. This is the first report of SARS-COV-2 exposure of domestic cats in Lima, Peru. Further studies are required to ascertain the prevalence of SARS-COV-2 exposure among domestic cats.

Cats COVID-19 Neutralizing antibodies One health SARS-CoV-2 Serology

Structured evidence records

Evidence records

2 total
Serological Evidence 1 records
Serological Evidence Extraction confidence 1.00
Key finding

Serum neutralizing antibodies against SARS-CoV-2 were detected in domestic cats cohabiting with COVID-19-infected owners in Lima, Peru.

Virus
SARS-CoV-2
Location
Not specified
Supporting text

In this report we demonstrate the presence of serum neutralizing antibodies against the receptor binding-domain (RBD) of the SARS-CoV-2 in cats whose owners had been infected with SARS-CoV-2 in Lima, Peru, using a commercial competitive ELISA SARS-CoV-2 Surrogate Virus Neutralization Test.

Method
ELISA; SARS-CoV-2 Surrogate Virus Neutralization Test
Sample type
serum
Spillover Event 1 records
Spillover Event Extraction confidence 0.85
Key finding

Domestic cats cohabiting with SARS-CoV-2–infected owners in Lima, Peru, had neutralizing antibodies, indicating probable human-to-cat transmission.

Virus
SARS-CoV-2
Location
Peru Peru
Supporting text

We demonstrate the presence of serum neutralizing antibodies against the receptor binding-domain (RBD) of the SARS-CoV-2 in cats whose owners had been infected with SARS-CoV-2 in Lima, Peru.

Method
competitive ELISA; SARS-CoV-2 Surrogate Virus Neutralization Test
Study design
serological survey
Transmission direction
human-to-animal
Geographic raw
Lima, Peru
Country inferred
Peru