OmniVira

Evidence of neutralizing antibodies against SARS-CoV-2 in domestic cats living with owners with a history of COVID-19 in Lima - Peru.

Luis M Jara1 Cusi Ferradas2 Francesca Schiaffino1 Camila Sánchez-Carrión3 Ana Martínez-Vela4 Alexandra Ulloa3 Gisela Isasi-Rivas5 Angela Montalván5 Luis Guevara Sarmiento5 Manolo Fernández5 Mirko Zimic5,6
Affiliations 6 institutions
  1. Facultad de Medicina Veterinaria y Zootecnia, Universidad Peruana Cayetano Heredia, Lima, Peru.
  2. Unidad de Investigación en Enfermedades Emergentes y Cambio Climático (Emerge), Facultad de Salud Pública y Administración, Universidad Peruana Cayetano Heredia, Lima, Peru.
  3. Clínica Veterinaria Gatuario, Lima, Peru.
  4. Clínica Veterinaria Los Dominicos, Lima, Peru.
  5. Farmacológicos Veterinarios (FARVET), Chincha, Peru.
  6. Laboratorio de Bioinformática, Biología Molecular y Desarrollos Tecnológicos, Universidad Peruana Cayetano Heredia, Lima, Peru.
PMID34462726 DOI10.1016/j.onehlt.2021.100318 Year2021 Journal One health (Amsterdam, Netherlands) One Health Languageeng Statusppublish

Abstract

SARS-CoV-2 can infect a variety of wild and domestic animals worldwide. Of these, domestic cats are highly susceptible species and potential viral reservoirs. As such, it is important to investigate disease exposure in domestic cats in areas with active community transmission and high disease prevalence. In this report we demonstrate the presence of serum neutralizing antibodies against the receptor binding-domain (RBD) of the SARS-CoV-2 in cats whose owners had been infected with SARS-CoV-2 in Lima, Peru, using a commercial competitive ELISA SARS-CoV-2 Surrogate Virus Neutralization Test. Out of 41 samples, 17.1% (7/41) and 31.7% (13/41) were positive, using the cut-off inhibition value of 30% and 20%, respectively. Not all cats living in a single house had detectable neutralizing antibodies showing heterogenous exposure and immunity among cohabiting animals. This is the first report of SARS-COV-2 exposure of domestic cats in Lima, Peru. Further studies are required to ascertain the prevalence of SARS-COV-2 exposure among domestic cats.

Supporting text Virus Host Location
Cats 133 COVID-19 467 Neutralizing antibodies 5 One health 98 SARS-CoV-2 550 Serology 50

Evidence records

1 total
Zoonotic Surveillance
1 records · 1 evidence types
Evidence type Serological Evidence
1 records
OVE5117 Serological Evidence
Key finding

Neutralizing antibodies against the receptor binding domain of SARS-CoV-2 were detected in domestic cats living with COVID-19-positive owners in Lima, Peru.

Virus
Severe acute respiratory syndrome coronavirus 2
Host
domestic cat Felis catus Natural host
Location
Not specified
Supporting text

In this report we demonstrate the presence of serum neutralizing antibodies against the receptor binding-domain (RBD) of the SARS-CoV-2 in cats whose owners had been infected with SARS-CoV-2 in Lima, Peru, using a commercial competitive ELISA SARS-CoV-2 Surrogate Virus Neutralization Test. Out of 41 samples, 17.1% (7/41) and 31.7% (13/41) were positive, using the cut-off inhibition value of 30% and 20%, respectively.

Method
commercial competitive ELISA SARS-CoV-2 Surrogate Virus Neutralization Test
Sample type
serum