OmniVira

Literature detail

A retrospective study showing a high rate of seropositivity against SARS-CoV-2 in wild felines in India.

Richa Borkakoti1 M Karikalan2 Sanket Kumar Nehul3 Harsh Rajeshbhai Jogi1 Kirtika Sharma2 Sushmita Nautiyal1 Ragini Mishra1 Sonalika Mahajan4 Sanchay Kumar Biswas1 Sukdeb Nandi1 Vishal Chander5,6 Abhijit Pawde2 G Saikumar7 Karam Pal Singh1 Gaurav Kumar Sharma8
Affiliations 8 institutions
  1. CADRAD, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, Bareilly, 243122, India.
  2. Center for Wildlife Conservation Management and Disease Surveillance, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, Bareilly, 243122, India.
  3. Indian Institute of Technology, Roorkee, 247667, Uttarakhand, India.
  4. Biological Standardization Division, ICAR-Indian Veterinary Research Institute, Izatnagar Bareilly, Izatnagar Uttar Pradesh, 243122, Uttar Pradesh, India.
  5. Division of Virology, ICAR-Indian Veterinary Research Institute, Mukteshwar, 263138, Uttarakhand, India.
  6. CADRAD, ICAR-Indian Veterinary Research Institute Izatnagar, Bareilly, 243122, Uttar Pradesh, India.
  7. Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, Bareilly, 243122, India.
  8. CADRAD, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, Bareilly, 243122, India. [email protected].
PMID 36914777 2023 Arch Virol eng epublish
PubMed DOI Browse context

Article

Publication summary

We report a high rate of seropositivity against SARS-CoV-2 in wild felines in India. Seropositivity was determined by microneutralization and plaque reduction neutralization assays in captive Asiatic lions, leopards, and Bengal tigers. The rate of seropositivity was positively correlated with that of the incidence in humans, suggesting the occurrence of large spillover events.

COVID-19 Lions Panthera Tigers Animals Cats Humans India Retrospective Studies SARS-CoV-2

Structured evidence records

Evidence records

6 total
Serological Evidence 3 records
Serological Evidence Extraction confidence 0.95
Key finding

Captive Asiatic lions, leopards, and Bengal tigers in India showed a high rate of seropositivity against SARS-CoV-2 as measured by neutralization assays.

Virus
SARS-CoV-2
Location
Not specified
Supporting text

Seropositivity was determined by microneutralization and plaque reduction neutralization assays in captive Asiatic lions, leopards, and Bengal tigers in India.

Method
microneutralization; plaque reduction neutralization assay
Sample type
serum
Serological Evidence Extraction confidence 0.95
Key finding

Leopards in India exhibited serological evidence of SARS-CoV-2 exposure detected through neutralization assays.

Virus
SARS-CoV-2
Location
Not specified
Supporting text

Seropositivity was determined by microneutralization and plaque reduction neutralization assays in captive Asiatic lions, leopards, and Bengal tigers in India.

Method
microneutralization; plaque reduction neutralization assay
Sample type
serum
Serological Evidence Extraction confidence 0.95
Key finding

Bengal tigers in India tested seropositive for SARS-CoV-2 antibodies using neutralization assays.

Virus
SARS-CoV-2
Location
Not specified
Supporting text

Seropositivity was determined by microneutralization and plaque reduction neutralization assays in captive Asiatic lions, leopards, and Bengal tigers in India.

Method
microneutralization; plaque reduction neutralization assay
Sample type
serum
Spillover Event 3 records
Spillover Event Extraction confidence 0.90
Key finding

Captive Asiatic lions, leopards, and Bengal tigers in India showed SARS-CoV-2 antibodies, with correlation to human cases suggesting human-to-feline spillback transmission.

Virus
SARS-CoV-2
Location
India India
Supporting text

Seropositivity was determined by microneutralization and plaque reduction neutralization assays in captive Asiatic lions, leopards, and Bengal tigers. The rate of seropositivity was positively correlated with that of the incidence in humans, suggesting the occurrence of large spillover events.

Method
microneutralization; plaque reduction neutralization assay
Study design
retrospective study
Transmission direction
human-to-animal
Geographic raw
India
Country inferred
India
Spillover Event Extraction confidence 0.90
Key finding

Captive leopards in India were seropositive for SARS-CoV-2, consistent with human-to-leopard spillback events.

Virus
SARS-CoV-2
Location
India India
Supporting text

Seropositivity was determined by microneutralization and plaque reduction neutralization assays in captive Asiatic lions, leopards, and Bengal tigers. The rate of seropositivity was positively correlated with that of the incidence in humans, suggesting the occurrence of large spillover events.

Method
microneutralization; plaque reduction neutralization assay
Study design
retrospective study
Transmission direction
human-to-animal
Geographic raw
India
Country inferred
India
Spillover Event Extraction confidence 0.90
Key finding

Captive Bengal tigers in India showed antibodies to SARS-CoV-2, indicating human-to-tiger spillback transmission.

Virus
SARS-CoV-2
Location
India India
Supporting text

Seropositivity was determined by microneutralization and plaque reduction neutralization assays in captive Asiatic lions, leopards, and Bengal tigers. The rate of seropositivity was positively correlated with that of the incidence in humans, suggesting the occurrence of large spillover events.

Method
microneutralization; plaque reduction neutralization assay
Study design
retrospective study
Transmission direction
human-to-animal
Geographic raw
India
Country inferred
India