OmniVira

Literature detail

Panoramic analysis of coronaviruses carried by representative bat species in Southern China to better understand the coronavirus sphere.

Yelin Han1,2,3,4 Panpan Xu1,2,3,4 Yuyang Wang1,2,3,4 Wenliang Zhao1,2,3,4 Junpeng Zhang5 Shuyi Zhang5 Jianwei Wang1 Qi Jin6,7,8 Zhiqiang Wu9,10,11,12
Affiliations 12 institutions
  1. NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
  2. Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
  3. Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of Education, Beijing, China.
  4. State Key Laboratory of Respiratory Health and Multimorbidity, Chinese Academy of Medical Sciences, Beijing, China.
  5. College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
  6. NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. [email protected].
  7. Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of Education, Beijing, China. [email protected].
  8. State Key Laboratory of Respiratory Health and Multimorbidity, Chinese Academy of Medical Sciences, Beijing, China. [email protected].
  9. NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. [email protected].
  10. Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. [email protected].
  11. Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of Education, Beijing, China. [email protected].
  12. State Key Laboratory of Respiratory Health and Multimorbidity, Chinese Academy of Medical Sciences, Beijing, China. [email protected].
PMID 37684236 2023 Nat Commun eng epublish
PubMed DOI Browse context

Article

Publication summary

Bats, recognized as considerable reservoirs for coronaviruses (CoVs), serve as natural hosts for several highly pathogenic CoVs, including SARS-CoV and SARS-CoV-2. Investigating the bat CoV community provides insights into the origin for highly pathogenic CoVs and highlights bat CoVs with potential spillover risks. This study probes the evolution, recombination, host range, geographical distribution, and cross-species transmission characteristics of bat CoVs across China and its associated CoVs in other regions. Through detailed research on 13,064 bat samples from 14 provinces of China, 1141 CoV strains are found across 10 subgenera and one unclassified Alpha-CoV, generating 399 complete genome sequences. Within bat CoVs, 11 new CoV species are identified and 425 recombination events are detected. Bats in southern China, particularly in Yunnan province, exhibit a pronounced diversity of CoVs. Limited sampling and low detection rates exist for CoVs in Myotacovirus, Nyctacovirus, Hibecovirus, Nobecovirus in China. The genus Myotis is highlighted as a potential ancestral host for Alpha-CoV, with the genus Hipposideros suggested as a likely progenitor host for bat-associated Beta-CoV, indicating the complexity of cross-species transmission dynamics. Through the comprehensive analysis, this study enriches the understanding of bat CoVs and offers a valuable resource for future research.

Alphacoronavirus Chiroptera COVID-19 Severe acute respiratory syndrome-related coronavirus Animals China SARS-CoV-2

Structured evidence records

Evidence records

7 total
Reservoir Ecology 3 records
Reservoir Ecology Extraction confidence 0.90
Key finding

Bats in southern China, especially in Yunnan province, act as natural reservoirs hosting a diverse assemblage of coronaviruses including SARS-CoV and SARS-CoV-2 relatives.

Host
Chiroptera
Location
China China
Supporting text

Bats, recognized as considerable reservoirs for coronaviruses (CoVs), serve as natural hosts for several highly pathogenic CoVs, including SARS-CoV and SARS-CoV-2. Bats in southern China, particularly in Yunnan province, exhibit a pronounced diversity of CoVs.

Method
field sampling; genomic sequencing
Sample type
bat samples
Geographic raw
southern China, particularly in Yunnan province
Country inferred
China
Reservoir Ecology Extraction confidence 0.85
Key finding

Myotis bats are proposed as ancestral hosts for Alphacoronaviruses, while Hipposideros bats may represent progenitor hosts for bat-associated Betacoronaviruses.

Host
Myotis
Location
China China
Supporting text

The genus Myotis is highlighted as a potential ancestral host for Alpha-CoV, with the genus Hipposideros suggested as a likely progenitor host for bat-associated Beta-CoV.

Method
phylogenetic analysis
Geographic raw
China
Country inferred
China
Reservoir Ecology Extraction confidence 0.85
Key finding

Hipposideros bats are identified as likely progenitor hosts for bat-associated Betacoronaviruses.

Location
China China
Supporting text

The genus Myotis is highlighted as a potential ancestral host for Alpha-CoV, with the genus Hipposideros suggested as a likely progenitor host for bat-associated Beta-CoV.

Method
phylogenetic analysis
Geographic raw
China
Country inferred
China
Cross Species Transmission 1 records
Cross Species Transmission Extraction confidence 0.85
Key finding

Alpha-CoV and Beta-CoV show evidence of cross-species transmission among bat genera, with Myotis and Hipposideros implicated in viral host jumps.

Location
China China
Supporting text

The genus Myotis is highlighted as a potential ancestral host for Alpha-CoV, with the genus Hipposideros suggested as a likely progenitor host for bat-associated Beta-CoV, indicating the complexity of cross-species transmission dynamics.

Method
genome sequencing; phylogenetic analysis; recombination analysis
Study design
phylogenetic analysis
Transmission direction
animal-to-animal
Geographic raw
China
Country inferred
China
Genomic Evolution 1 records
Genomic Evolution Extraction confidence 0.90
Key finding

Genome sequencing and phylogenetic analysis of bat coronaviruses revealed 11 new CoV species, numerous recombination events, and indicated Myotis and Hipposideros bats as ancestral hosts for Alpha-CoV and Beta-CoV respectively.

Location
Not specified
Supporting text

Through detailed research on 13,064 bat samples from 14 provinces of China, 1141 CoV strains are found across 10 subgenera and one unclassified Alpha-CoV, generating 399 complete genome sequences. Within bat CoVs, 11 new CoV species are identified and 425 recombination events are detected. The genus Myotis is highlighted as a potential ancestral host for Alpha-CoV, with the genus Hipposideros suggested as a likely progenitor host for bat-associated Beta-CoV.

Genes or proteins
whole genome
Analysis methods
genome sequencing; phylogenetic analysis; recombination analysis
Recombination Or Reassortment 1 records
Recombination Or Reassortment Extraction confidence 0.95
Key finding

The study detected 425 recombination events among bat coronaviruses in China, showing widespread recombination within bat CoVs.

Host
Not specified
Location
Not specified
Supporting text

Within bat CoVs, 11 new CoV species are identified and 425 recombination events are detected.

Event type
recombination
Zoonotic Surveillance 1 records
Zoonotic Surveillance Extraction confidence 0.95
Key finding

Surveillance of bats across southern China revealed extensive coronavirus diversity, identifying over a thousand CoV strains and numerous complete genomes from bat samples.

Host
Chiroptera
Location
China southern China, China
Supporting text

Through detailed research on 13,064 bat samples from 14 provinces of China, 1141 CoV strains are found across 10 subgenera and one unclassified Alpha-CoV, generating 399 complete genome sequences.

Method
genome sequencing
Geographic raw
southern China
Country inferred
China