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Literature detail

Tropism and Replication Competence of Cattle Influenza A(H5N1) Genotype B3.13 Virus in Human Bronchus and Lung Tissue.

Kenrie P Y Hui John C W Ho Ka-Chun Ng Richard J Webby Malik Peiris John M Nicholls Michael C W Chan
PMID 41922194 2026 Emerg Infect Dis eng aheadofprint
PubMed DOI Browse context

Article

Publication summary

In 2024, influenza A(H5N1) genotype B3.13 viruses emerged from cattle and caused mild spillover infections in humans. Using human bronchus and lung tissue, we evaluated tropism, replication, and pathogenesis of 2 cattle influenza isolates. Those viruses showed moderate replication competence and induced robust proinflammatory responses, suggesting potential risk for human health.

cattle influenza cytokine ex vivo H5N1 Hong Kong human respiratory tract inflammatory Influenza respiratory infections viruses zoonoses Bronchi Cattle Diseases Influenza A Virus, H5N1 Subtype Influenza, Human Lung Orthomyxoviridae Infections Viral Tropism

Structured evidence records

Evidence records

2 total
Molecular Adaptation 1 records
Molecular Adaptation Extraction confidence 0.85
Key finding

Cattle-origin influenza A(H5N1) genotype B3.13 viruses exhibit moderate replication competence and tropism in human respiratory tissue, indicating molecular adaptation toward human infection.

Virus
IAV H5N1
Host
Not specified
Location
Not specified
Supporting text

Using human bronchus and lung tissue, we evaluated tropism, replication, and pathogenesis of 2 cattle influenza isolates. Those viruses showed moderate replication competence and induced robust proinflammatory responses.

Mechanism types
tissue_tropism; replication_efficiency; pathogenicity
Spillover Event 1 records
Spillover Event Extraction confidence 0.98
Key finding

Influenza A(H5N1) genotype B3.13 viruses originating from cattle caused mild infections in humans, representing an animal-to-human spillover event.

Virus
IAV H5N1
Location
Not specified
Supporting text

In 2024, influenza A(H5N1) genotype B3.13 viruses emerged from cattle and caused mild spillover infections in humans.

Transmission direction
animal-to-human