OmniVira

Anthropogenic Transmission of SARS-CoV-2 from Humans to Lions, Singapore, 2021.

Yin Cheong Aden Ip Adrian Tan Jasmine Ong Charlene Judith Fernandez Clara Lau Wai Kwan Wong Siow Foong Chang Him Hoo Yap Kenneth B H Er
PMID37885046 DOI10.3201/eid2912.221916 Year2023 Journal Emerging infectious diseases Emerg Infect Dis Languageeng Statusppublish

Abstract

In Singapore, 10 captive lions tested positive for SARS-CoV-2 by real-time PCR. Genomic analyses of nanopore sequencing confirmed human-to-animal transmission of the SARS-CoV-2 Delta variant. Viral genomes from the lions and zookeeper shared a unique spike protein substitution, S:A1016V. Widespread SARS-CoV-2 transmission among humans can increase the likelihood of anthroponosis.

Supporting text Virus Host Location
coronavirus 195 COVID-19 467 Delta variant 8 endangered species 3 human-to-animal transmission 3 lion 4 nanopore sequencing 5 Panthera 6 respiratory infections 30 reverse zoonosis 38 SARS-CoV-2 550 Singapore 5 viral genome 3 viruses 117 zoo 3 zoonoses 477 COVID-19 425 Lions 8 Animals 1948 Humans 1440 SARS-CoV-2 453 Singapore 5 SARS-CoV-2 variants 86

Evidence records

2 total
Zoonotic Surveillance
1 records · 1 evidence types
Evidence type Viral Detection
1 records
Transmission Evidence
1 records · 1 evidence types
Evidence type Cross-species Transmission
1 records
OVE7493 Cross-species Transmission
Key finding

Genomic analyses confirmed human-to-animal transmission of the SARS-CoV-2 Delta variant from a zookeeper to lions in Singapore.

Virus
Severe acute respiratory syndrome coronavirus 2
Host
lion Panthera leo Natural host human Homo sapiens Natural host
Location
Singapore
Supporting text

In Singapore, 10 captive lions tested positive for SARS-CoV-2 by real-time PCR. Genomic analyses of nanopore sequencing confirmed human-to-animal transmission of the SARS-CoV-2 Delta variant.

Method
real-time PCR | nanopore sequencing | genomic comparison
Study design
genomic investigation of zoo lion infections linked to human source
Transmission direction
human-to-animal
Geographic raw
Singapore