OmniVira

Distribution and genetic characterization of hantaviruses in bats and rodents from Yunnan.

Yutong Hou1 Qian Li1,2 Xingyu Huang1 Jiale Wang1 Junjie Hou1 Yunze Sun1 Xinrui Wu1 Ziqin Dian3 Binghui Wang4 Xueshan Xia1,4
Affiliations 4 institutions
  1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, P.R. China.
  2. Dali University, Dali, P.R. China.
  3. Department of Clinical Laboratory, The First People's Hospital of Yunnan Province, Yunnan, P.R. China.
  4. School of Public Health, Kunming Medical University, Kunming, China.
PMID39208380 DOI10.1371/journal.pntd.0012437 Year2024 Journal PLoS neglected tropical diseases PLoS Negl Trop Dis Languageeng Statusepublish

Abstract

Hemorrhagic fever with renal syndrome caused by hantaviruses has long been a serious public health issue in Yunnan Province. Hantaviruses exhibit a high extent of biodiversity in their natural hosts, particularly in mammalian hosts. This study was conducted to screen for hantaviruses in bats and rodents in Yunnan Province and elucidate their genetic characteristics and possible zoonotic disease risk. Hantaviruses were detected in 202 bats and 372 rodents with the positive rates 27.49% and 1.25% respectively. A novel lineage (named Lineage 10) of the Seoul virus (SEOV) from rodents and the geographic clustering of hantavirus in bats were identified using phylogenetic analyses of the full-length M- and S-segments. Our study suggest a high cross-species transmissibility of hantaviruses in bats and existence of a new lineage of SEOV in rodents differing significantly from other SEOVs. These results provide data to support the prevention and control of hantavirus-associated diseases in Yunnan Province.

Supporting text Virus Host Location
Chiroptera 372 Orthohantavirus 18 Phylogeny 805 Rodentia 51 Animals 1949 China 229 Hantavirus Infections 16 Seoul virus 4

Evidence records

5 total
Zoonotic Surveillance
2 records · 1 evidence types
Evidence type Viral Detection
2 records
OVE8345 Viral Detection
Key finding

Hantaviruses were detected in bats from Yunnan Province with a positivity rate of 27.49%.

Virus
Hantaviridae
Host
bats Chiroptera Natural host
Location
China
Supporting text

This study was conducted to screen for hantaviruses in bats and rodents in Yunnan Province and elucidate their genetic characteristics and possible zoonotic disease risk. Hantaviruses were detected in 202 bats and 372 rodents with the positive rates 27.49% and 1.25% respectively.

Method
screening | phylogenetic analyses | full-length M- and S-segment sequencing
Sample type
bat specimens
Geographic raw
Yunnan Province
Country inferred
CHN
OVE8346 Viral Detection
Key finding

Hantaviruses were detected in rodents from Yunnan Province with a positivity rate of 1.25%.

Virus
Hantaviridae
Host
rodents Rodentia Natural host
Location
China
Supporting text

This study was conducted to screen for hantaviruses in bats and rodents in Yunnan Province and elucidate their genetic characteristics and possible zoonotic disease risk. Hantaviruses were detected in 202 bats and 372 rodents with the positive rates 27.49% and 1.25% respectively.

Method
screening | phylogenetic analyses | full-length M- and S-segment sequencing
Sample type
rodent specimens
Geographic raw
Yunnan Province
Country inferred
CHN
Genomic Evolution
3 records · 1 evidence types
Evidence type Phylogenetic Evolution
3 records
OVE8347 Phylogenetic Evolution
Key finding

Phylogenetic analysis of full-length M- and S-segments identified a novel Seoul virus lineage (Lineage 10) in rodents.

Virus
Seoul virus
Host
rodents Rodentia Natural host
Location
Not specified
Supporting text

A novel lineage (named Lineage 10) of the Seoul virus (SEOV) from rodents was identified using phylogenetic analyses of the full-length M- and S-segments.

Genes or proteins
M-segment | S-segment
Analysis methods
phylogenetic analysis
OVE8348 Phylogenetic Evolution
Key finding

Phylogenetic analyses showed geographic clustering of hantaviruses detected in bats.

Virus
Hantaviridae
Host
bats Chiroptera Natural host
Location
Not specified
Supporting text

Geographic clustering of hantavirus in bats was identified using phylogenetic analyses of the full-length M- and S-segments.

Genes or proteins
M-segment | S-segment
Analysis methods
phylogenetic analysis
OVE8349 Phylogenetic Evolution
Key finding

The study suggests high cross-species transmissibility of hantaviruses among bat species.

Virus
Hantaviridae
Host
bats Chiroptera Natural host
Location
Not specified
Supporting text

Our study suggest a high cross-species transmissibility of hantaviruses in bats and existence of a new lineage of SEOV in rodents differing significantly from other SEOVs.

Analysis methods
phylogenetic analysis | virus detection