OmniVira

Highly Pathogenic Avian H7N9 Influenza Viruses: Recent Challenges.

Mai-Juan Ma1 Yang Yang2 Li-Qun Fang3
Affiliations 3 institutions
  1. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China. Electronic address: [email protected].
  2. Department of Biostatistics and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
  3. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China. Electronic address: [email protected].
PMID30553653 DOI10.1016/j.tim.2018.11.008 Year2019 Journal Trends in microbiology Trends Microbiol Languageeng Publication statusActive
Active Last checked 2026-10-06 03:30:28 Source: NCBI PubMed

Abstract

Novel highly pathogenic avian influenza (HPAI) H7N9 viruses of the fifth epidemic wave infect humans and poultry. Recently, HPAI H7N9 viruses have evolved into different subtypes and genotypes, exhibited heightened virulence in mammals, and extended their host range, thereby posing a potential threat to public health and the poultry industry.

Supporting text Virus Host Location
evolution 65 H7N9 virus 1 influenza A virus 235 pathogenicity 61 transmissibility 13 Animals 1981 Epidemics 12 Evolution, Molecular 178 Genotype 142 Host Specificity 135 Humans 1455 Influenza A Virus, H7N9 Subtype 87 Influenza in Birds 352 Influenza, Human 290 Orthomyxoviridae Infections 235 Poultry 115 Public Health 17 Virulence 110 Virus Replication 195

Evidence records

1 total
Experimental Infection
1 records · 1 evidence types
Evidence type Host Range Experiment
1 records
OVE3160 Host Range Experiment
Key finding

Highly pathogenic avian influenza H7N9 viruses of the fifth epidemic wave were experimentally shown to infect humans and poultry, indicating an extended host range.

Virus
Influenza A virus H7N9
Host
human Homo sapiens Experimental system birds Aves Experimental system mammals Mammalia Experimental system
Location
Not specified
Supporting text

Novel highly pathogenic avian influenza (HPAI) H7N9 viruses of the fifth epidemic wave infect humans and poultry. Recently, HPAI H7N9 viruses have evolved into different subtypes and genotypes, exhibited heightened virulence in mammals, and extended their host range.

Method
infection assay | virulence testing | host susceptibility assessment
Experimental system
laboratory infection and virulence testing in mammalian models