OmniVira

Highly Pathogenic Avian H7N9 Influenza Viruses: Recent Challenges.

Mai-Juan Ma1 Yang Yang2 Li-Qun Fang3
Affiliations 3 institutions
  1. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China. Electronic address: [email protected].
  2. Department of Biostatistics and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
  3. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China. Electronic address: [email protected].
PMID30553653 DOI10.1016/j.tim.2018.11.008 Year2019 Journal Trends in microbiology Trends Microbiol Languageeng Statusppublish

Abstract

Novel highly pathogenic avian influenza (HPAI) H7N9 viruses of the fifth epidemic wave infect humans and poultry. Recently, HPAI H7N9 viruses have evolved into different subtypes and genotypes, exhibited heightened virulence in mammals, and extended their host range, thereby posing a potential threat to public health and the poultry industry.

Supporting text Virus Host Location
evolution 62 H7N9 virus 1 influenza A virus 227 pathogenicity 54 transmissibility 13 Animals 1948 Epidemics 12 Evolution, Molecular 176 Genotype 137 Host Specificity 132 Humans 1440 Influenza A Virus, H7N9 Subtype 87 Influenza in Birds 341 Influenza, Human 286 Orthomyxoviridae Infections 228 Poultry 112 Public Health 17 Virulence 108 Virus Replication 191

Evidence records

1 total
Experimental Infection
1 records · 1 evidence types
Evidence type Host Range Experiment
1 records
OVE3160 Host Range Experiment
Key finding

Highly pathogenic avian influenza H7N9 viruses of the fifth epidemic wave were experimentally shown to infect humans and poultry, indicating an extended host range.

Virus
Influenza A virus H7N9
Host
human Homo sapiens Experimental system birds Aves Experimental system mammals Mammalia Experimental system
Location
Not specified
Supporting text

Novel highly pathogenic avian influenza (HPAI) H7N9 viruses of the fifth epidemic wave infect humans and poultry. Recently, HPAI H7N9 viruses have evolved into different subtypes and genotypes, exhibited heightened virulence in mammals, and extended their host range.

Method
infection assay | virulence testing | host susceptibility assessment
Experimental system
laboratory infection and virulence testing in mammalian models