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Literature detail

Experimental Infection of Mink with SARS-COV-2 Omicron Variant and Subsequent Clinical Disease.

Jenni Virtanen Kirsi Aaltonen Kristel Kegler Vinaya Venkat Thanakorn Niamsap Lauri Kareinen Rasmus Malmgren Olga Kivelä Nina Atanasova Pamela Österlund Teemu Smura Antti Sukura Tomas Strandin Lara Dutra Olli Vapalahti Heli Nordgren Ravi Kant Tarja Sironen
PMID 35608951 2022 Emerg Infect Dis eng ppublish
PubMed DOI Browse context

Article

Publication summary

We report an experimental infection of American mink with SARS-CoV-2 Omicron variant and show that mink remain positive for viral RNA for days, experience clinical signs and histopathologic changes, and transmit the virus to uninfected recipients. Preparedness is crucial to avoid spread among mink and spillover to human populations.

animals coronavirus disease COVID-19 Finland mink models respiratory infections SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 viruses zoonoses COVID-19 SARS-CoV-2 Animals Humans Mink SARS-CoV-2 variants

Structured evidence records

Evidence records

2 total
Cross Species Transmission 1 records
Cross Species Transmission Extraction confidence 0.92
Key finding

Mink experimentally infected with the SARS-CoV-2 Omicron variant transmitted the virus to uninfected mink, demonstrating animal-to-animal transmission within a non-human species.

Virus
SARS-CoV-2
Location
Finland Finland
Supporting text

We report an experimental infection of American mink with SARS-CoV-2 Omicron variant and show that mink remain positive for viral RNA for days, experience clinical signs and histopathologic changes, and transmit the virus to uninfected recipients.

Method
experimental infection; virus detection
Study design
animal experiment
Transmission direction
animal-to-animal
Geographic raw
Finland
Country inferred
Finland
Host Range Experiment 1 records
Host Range Experiment Extraction confidence 0.98
Key finding

American mink experimentally infected with SARS-CoV-2 Omicron variant showed viral RNA persistence, clinical disease, and were able to transmit the virus to uninfected mink.

Virus
SARS-CoV-2
Location
Not specified
Supporting text

We report an experimental infection of American mink with SARS-CoV-2 Omicron variant and show that mink remain positive for viral RNA for days, experience clinical signs and histopathologic changes, and transmit the virus to uninfected recipients.

Method
experimental infection
Experimental system
in vivo animal experiment