OmniVira

Experimental Infection of Mink with SARS-COV-2 Omicron Variant and Subsequent Clinical Disease.

Jenni Virtanen Kirsi Aaltonen Kristel Kegler Vinaya Venkat Thanakorn Niamsap Lauri Kareinen Rasmus Malmgren Olga Kivelä Nina Atanasova Pamela Österlund Teemu Smura Antti Sukura Tomas Strandin Lara Dutra Olli Vapalahti Heli Nordgren Ravi Kant Tarja Sironen
PMID35608951 DOI10.3201/eid2806.220328 Year2022 Journal Emerging infectious diseases Emerg Infect Dis Languageeng Statusppublish

Abstract

We report an experimental infection of American mink with SARS-CoV-2 Omicron variant and show that mink remain positive for viral RNA for days, experience clinical signs and histopathologic changes, and transmit the virus to uninfected recipients. Preparedness is crucial to avoid spread among mink and spillover to human populations.

Supporting text Virus Host Location
animals 1952 coronavirus disease 15 COVID-19 467 Finland 3 mink 58 models 2 respiratory infections 30 SARS-CoV-2 550 severe acute respiratory syndrome coronavirus 2 20 viruses 117 zoonoses 477 COVID-19 425 SARS-CoV-2 453 Animals 1949 Humans 1441 Mink 48 SARS-CoV-2 variants 86

Evidence records

2 total
Experimental Infection
2 records · 2 evidence types
Evidence type Pathogenicity Experiment
1 records
OVE5974 Pathogenicity Experiment
Key finding

American mink experimentally infected with the SARS-CoV-2 Omicron variant showed clinical signs and histopathologic changes indicating pathogenic infection.

Virus
Severe acute respiratory syndrome coronavirus 2
Host
American mink Neogale vison Experimental system
Location
Not specified
Supporting text

We report an experimental infection of American mink with SARS-CoV-2 Omicron variant and show that mink remain positive for viral RNA for days, experience clinical signs and histopathologic changes, and transmit the virus to uninfected recipients.

Method
experimental infection | clinical observation | histopathologic examination | viral RNA detection
Experimental system
experimental infection of American mink
Evidence type Experimental Transmission
1 records
OVE5973 Experimental Transmission
Key finding

Experimentally infected American mink transmitted SARS-CoV-2 Omicron variant to uninfected recipient mink under controlled conditions.

Virus
Severe acute respiratory syndrome coronavirus 2
Host
American mink Neogale vison Experimental system
Location
Not specified
Supporting text

We report an experimental infection of American mink with SARS-CoV-2 Omicron variant and show that mink remain positive for viral RNA for days, experience clinical signs and histopathologic changes, and transmit the virus to uninfected recipients.

Method
experimental infection | RT-qPCR detection of viral RNA | clinical observation | histopathology
Experimental system
animal transmission model (infected and uninfected mink under controlled experimental exposure)